Publications by authors named "Bouvier Anne-Marie"
Introduction: Surgical resection is the standard recommended treatment in localized pancreatic cancer. The benefit of neoadjuvant chemotherapy is still debated. The aim of this population-based study was to describe the pancreatic cancer surgical management.
View Article and Find Full Text PDFBackground: The impact of geographical accessibility on cancer survival has been investigated in few studies, with most research focusing on access to reference care centers, using overall mortality and limited to specific cancer sites. This study aims to examine the association of access to primary care with mortality in excess of patients with the 10 most frequent cancers in France, while controlling for socioeconomic deprivation.
Methods: This study included a total of 151,984 cases diagnosed with the 10 most common cancer sites in 21 French cancer registries between 2013 and 2015.
Article Synopsis
- A new modeling approach was developed to better estimate the cancer cure fraction (CF) and net survival by considering patients' increased risk of dying from causes other than cancer, rather than assuming equal mortality rates with the general population.
- Data from EUROCARE-6 on head and neck, colorectal, and breast cancer patients aged 40-79 was analyzed, revealing a significant increase in CF, particularly among younger males with head and neck cancer who had a fourfold increased risk of dying from other causes.
- Ignoring the higher mortality risk from non-cancer causes leads to an underestimation of the CF, which is crucial for understanding patient survival and improving their quality of life.
Article Synopsis
- A study was conducted to analyze the frequency of metastatic sites in colorectal cancer using a comprehensive cancer registry spanning from 1991 to 2020, with 5,199 cases examined.
- The most common metastatic sites identified were the liver, peritoneum, lung, and bone, with interesting trends showing a decline in liver and lung metastases in men and an increase in these sites for women over time.
- The research also found that rare metastatic sites, such as adrenal glands and supraclavicular lymph nodes, saw a doubling in incidence between 2016 and 2020 compared to the previous 25 years, and specific genetic variants were linked to the presence of certain metastases.
Recurrence after colorectal cancer resection is rarely documented in the general population while a key clinical determinant for patient survival. We identified 8785 patients with colorectal cancer diagnosed between 2010 and 2013 and clinically followed up to 2020 in 15 cancer registries from seven European countries (Bulgaria, Switzerland, Germany, Estonia, France, Italy, and Spain). We estimated world age-standardized net survival using a flexible cumulative excess hazard model.
View Article and Find Full Text PDFBackground And Aims: To measure the impact of socio-economic environment on the incidence of hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (iCCA).
Method: The study used data from the French Network of Cancer Registries (FRANCIM) between 2006 and 2016. Classification of patients into HCC and iCCA was performed according to the topographical and morphological codes of the 3rd edition of the International Classification of Diseases for Oncology.
Aim: Real-life estimations of survival by stage in colorectal cancer are scanty. We estimated population-based net survival by pathological stage and location, and for rectal cancer by patterns of evolution according to clinical and pathological stage with regard to neoadjuvant therapy.
Method: Age-standardized net survival was estimated on 19,630 colorectal cancers diagnosed between 2009 and 2015.
Article Synopsis
- Resection is the primary treatment for pancreatic ductal adenocarcinoma (PDAC), and the volume of surgical cases at hospitals significantly affects post-operative mortality and survival rates.
- A study analyzed 763 PDAC patients from 2000-2014, categorizing hospitals into low, medium, and high-volume centers, finding that high-volume centers led to better survival outcomes and lower post-operative mortality.
- Factors like hospital surgical volume played a crucial role in survival differences, suggesting that improving patient management in hospitals can enhance outcomes for PDAC surgeries.
Background: Little is known about the epidemiology of biliary tract cancers over the last decade. We investigated trends in incidence, treatment and prognosis of biliary tract cancers according to anatomic site.
Methods: 714 biliary tract cancers recorded between 2012 and 2019 in the French population-based cancer registry of Burgundy were included.
Article Synopsis
- Stage II colon cancer accounts for 16% of colon cancer deaths, highlighting the need for better predictors of recurrence risk.
- Researchers developed a novel 40 CpG site-based classifier that categorizes stage II colon cancer into four subclasses with unique molecular characteristics, including changes linked to cell proliferation.
- Analysis revealed that hypermethylation of specific CpG sites significantly affects recurrence risk and is associated with distinct immune cell infiltration patterns, providing insights for personalized treatment strategies for stage II colon cancer patients.
Oncological strategies in the elderly population are debated. The objective of this study was to determine the predictive factors of survival in patients aged 80 years and older with metastatic colon cancer. Data from four digestive tumour registry databases were used in this analysis.
View Article and Find Full Text PDFImportance: Although treatment and prognosis of synchronous liver metastases from colorectal cancer are relatively well known, a comparative description of the incidence, epidemiological features, and outcomes of synchronous and metachronous liver metastases is lacking. The difference in prognosis between patients with synchronous and metachronous liver metastases is controversial.
Objective: To investigate temporal patterns in the incidence and outcomes of synchronous vs metachronous liver metastases from colorectal cancer.
Article Synopsis
- The study focused on assessing the cancer risk associated with pathogenic variants (PV) in families meeting the hereditary diffuse gastric cancer (HDGC) criteria.
- Researchers gathered data from existing families and collaborated internationally to analyze the cumulative risk of diffuse gastric cancer (DGC) for PV carriers using advanced statistical methods.
- Findings revealed that PV carriers face a cumulative DGC risk of 49% to 57% by age 80, with significantly heightened risk ratios at earlier ages, marking this as a critical insight for improving patient management and genetic testing.
Background: Cancer prevalence is heterogeneous because it includes individuals who are undergoing initial treatment and those who are in remission, experiencing relapse, or cured. The proposed statistical approach describes the health status of this group by estimating the probabilities of death among prevalent cases. The application concerns colorectal, lung, breast, and prostate cancers and melanoma in France in 2017.
View Article and Find Full Text PDFBackground: An increasing proportion of colorectal cancers (CRCs) are detected through screening due to the availability of organised population-based programmes. We aimed to analyse survival probabilities of patients with screen-detected CRC in European countries.
Methods: Data from CRC patients were obtained from 16 population-based cancer registries in nine European countries.
Aim: Stratification of colon cancer (CC) of patients with stage II and III for risk of relapse is still needed especially to drive adjuvant therapy administration. Our study evaluates the prognostic performance of two known biomarkers, CDX2 and CD3, standalone or their combined information in stage II and III CC.
Patients And Methods: CDX2 and CD3 expression was evaluated in Prodige-13 study gathering 443 stage II and 398 stage III primary CC on whole slide colectomy.
Background: The effects of recently implemented colorectal cancer screening programmes in Europe on colorectal cancer mortality will take several years to be fully known. We aimed to analyse the characteristics and parameters of screening programmes, proportions of colorectal cancers detected through screening, and stage distribution in screen-detected and non-screen-detected colorectal cancers to provide a timely assessment of the potential effects of screening programmes in several European countries.
Methods: We conducted this population-based study in nine European countries for which data on mode of detection were available (Belgium, Denmark, England, France, Italy, Ireland, the Netherlands, Slovenia, and Spain).
Background: Our objective was to describe real-world patterns of care and outcomes in pancreatic cancer. Methods: 912 patients diagnosed with pancreatic cancer from 2014 to 2017 were registered by the population-based cancer registry of Burgundy (France). Progression-free and net survival were estimated.
View Article and Find Full Text PDFBackground: Sarcomas are rare, heterogeneous, ubiquitously localized malignancies with many histologic subtypes and genomic patterns. The survival of patients with sarcoma has rarely been described based on this heterogeneity; therefore, the authors' objective was to estimate survival outcomes in patients who had sarcomas using the 2020 version of the World Health Organization classification of soft tissue and bone tumors.
Methods: Patients older than 15 years who had incident sarcoma diagnosed between 2005 and 2010 were extracted from 14 French population-based cancer registries covering 18% of the French metropolitan population.
Article Synopsis
- Epidemiology data from the Francim Cancer Registry show that in 2018, France diagnosed 13,744 new cases of rectal cancer, with a slight decrease in incidence since 1990 and a decreasing male-to-female ratio from 2.1 to 1.8 over time.
- Nearly half of the cases were found at a local extension stage, while others were diagnosed at regional (20%) or advanced stages (34%).
- The five-year survival rates are 60% for men and 59% for women, with participation in fecal occult bleeding screening being inefficient due to a low participation rate of only 30%, below the 45% needed for effective screening.
Surgical treatment of digestive cancer in a well-defined elderly population.
Clin Res Hepatol Gastroenterol
March 2022
Introduction: Digestive cancer is of concern because of its frequency and severity with an increasing older median age of onset. The purpose of this study was to describe in a well-defined population presenting with non-metastatic digestive cancer the frequency of surgical resection and outcomes according to age.
Patients And Methods: We analyzed 7760 patients with a non-metastatic digestive cancer, recorded in the Burgundy population-based digestive cancer registry between 2009 and 2017.
Social inequalities are an important prognostic factor in cancer survival, but little is known regarding digestive cancers specifically. We aimed to provide in-depth analysis of the contextual social disparities in net survival of patients with digestive cancer in France, using population-based data and relevant modeling. Digestive cancers ( = 54,507) diagnosed between 2006-2009, collected through the French network of cancer registries, were included (end of follow-up 30 June 2013).
View Article and Find Full Text PDFArticle Synopsis
- The study investigates how deprivation, healthcare access, and the healthcare system impact the likelihood of receiving non-restorative rectal cancer surgery (NRRCS) among patients.
- An analysis of nearly 3,000 patients shows that factors like age, tumor characteristics, and treatment history are significantly linked to the chance of receiving NRRCS, while socioeconomic factors like deprivation and healthcare location do not seem to affect it.
- The findings suggest that the type of healthcare facility and its surgical volume play a minor role in NRRCS outcomes, with the majority of variability in surgery decisions attributed to clinical factors rather than healthcare structure differences.
Background: Little is known about the management of squamous cell carcinoma of the anal canal and its recurrence at a population level. The aim of this study was to draw a picture of management, recurrence and survival in squamous cell carcinoma of the anal canal.
Material And Methods: The 5-year probability of recurrences was estimated using the cumulative incidence function to consider competing risks of death.