Internal Tandem Duplication of Exon 8 of Is Associated With Longer Total Survival in Canine Cutaneous Mast Cell Tumors.

Canine cutaneous mast cell tumors (ccMCTs) have a highly variable biological behavior and accurate prognostication is essential for therapeutic intervention. Internal tandem duplications (ITD) of exon 11 are the most commonly detected mutation in ccMCTs and are associated with poor prognosis and increased cellular proliferation. The prognostic value of detecting mutations in other exons of has not been systematically examined.

Resection of urachal anomalies in dogs with recurrent lower urinary tract disease.

Objective: To determine whether surgical removal of urachal anomalies improves the outcomes of dogs with recurrent lower urinary tract disease (LUTD) and bacterial urinary tract infection (BUTI).

Study Design: Retrospective study.

Animals: Thirty-three dogs with urachal anomalies and recurrent LUTD or BUTI.

Evaluation of candidate genes as a cause of chondrodysplasia in Labrador retrievers.

Chondrodysplasia (CD) is a disabling, hereditary disease in Labradors with short limbs, warranting genetic screening in families at risk. Segregation analysis of eight litters with 13 affected dogs showed that autosomal recessive inheritance was consistent with the observed incidence of CD in the litters. Possible involvement of eight candidate collagen genes (COL9A1, COL9A2, COL9A3, COMP, MATN3, COL2A1, COL11A1 and COL11A2) and of a sulfate transporter glycoprotein (SLC26A2) gene in eight affected dogs and in 14 related control Labradors was investigated.

Hypotonic water as adjuvant therapy for incompletely resected canine mast cell tumors: a randomized, double-blind, placebo-controlled study.

Objective: To evaluate efficacy of hypotonic water as adjuvant therapy after marginal resection of canine mast cell tumors (MCT).

Study Design: Double-blinded, placebo-controlled, prospective, randomized study.

Animals: Dogs (n=30) with spontaneous, cutaneous, solitary MCT.