Granulomatous slack skin: treatment with extensive surgery and review of the literature.

We report an 11-year follow-up of a case of granulomatous slack skin. The patient was first treated surgically followed by a rapid relapse. Then he was treated by alpha-interferon during 15 months.

Tumor regressions observed in patients with metastatic melanoma treated with an antigenic peptide encoded by gene MAGE-3 and presented by HLA-A1.

Thirty-nine tumor-bearing patients with metastatic melanoma were treated with 3 subcutaneous injections of the MAGE-3.A1 peptide at monthly intervals. No significant toxicity was observed.

About two cases of Mycobacterium simiae infection in AIDS: review of the pathogenicity.

Mycobacterium simiae is an ubiquitous species rarely involved as a cause of human infection. Its pathogenicity remains therefore unclear and controversial. Disseminated infections with M.

[Buschke-Loewenstein tumor. Apropos of 2 cases in Cotonou, Benin].

About two cases of Buschke-Loewenstein tumor--one of the penis in man infected with HIV and another of perianal area-, the authors insist on the relative frequency of Buschke-Loewenstein tumor in non-circumcised and homosexual groups. They emphasize the continuous precancerous spectrum of Buschke-Loewenstein tumor.

Mycobacterium simiae disseminated infection in a patient with acquired immunodeficiency syndrome.

Mycobacterium simiae is commonly found in nature and its role as a pathogen has been controversial. A case of disseminated M. simiae infection with blood, pulmonary and cutaneous localization is reported here.

Expression of MAGE genes in primary and metastatic cutaneous melanoma.

Human genes MAGE-1 and MAGE-3 code for antigens that are recognized on melanoma cells by autologous cytolytic T lymphocytes. These antigens may constitute useful targets for specific anti-tumor immunization of cancer patients, since genes MAGE-1 and MAGE-3 are expressed in a number of tumors of different histological types, but are not expressed in normal adult tissues other than testis. This also applies to genes MAGE-2 and MAGE-4, which are closely related to MAGE-1 and MAGE-3.

Ki-1 anaplastic primary cutaneous large-cell lymphoma.

A 63-year-old woman presented with a large, subumbilical ulcerated nodule that was a Ki-1+ anaplastic large-cell lymphoma with exclusively cutaneous localization. This high-grade lymphoma, in this case, has a less severe prognosis. Surgical resection or local radiotherapy seems sufficient for the localized cutaneous forms.

Retrolumbar subcutaneous ependymoma and giant bathing-trunk nevocellular nevus.

Background: Subcutaneous ependymomas have been reported rarely in dermatologic reviews and, apparently, were never associated with other cutaneous malformations.

Methods: A 60-year-old woman with a retrolumbar subcutaneous ependymoma and a giant bathing-trunk nevocellular nevus submitted to thorough dermatologic and neurologic investigation. The surgical material was extensively analyzed with light and electron microscope.

Pseudoxanthoma-elasticum-like papillary dermal elastolysis: a new case.

We report the clinicopathological features of an old woman with a recent and progressive development of soft white-yellow papules of the neck and supraclavicular areas reminding of pseudoxanthoma elasticum without systemic involvement. The similarity of this entity with fibroelastopathic papular dermatoses of the neck is briefly discussed.

[Longitudinal melanonychia and hydroxyurea].

A patient with chronic myeloid leukaemia was treated with hydroxyurea and developed longitudinal melanonychia on 10 of 20 nails. Such intense lesions are extremely rare.

Pigmented epidermotropic metastasis of a breast carcinoma.

Mammary and extramammary Paget's disease is believed to remain non-pigmented, in contrast to superficial pagetoid melanoma; the same holds true for epidermotropic metastases of breast carcinoma. We recently had the opportunity to observe intensively pigmented epidermotropic metastasis of breast carcinoma, with dispersion of melanocytes in the dermal infiltrate. Similar observations, although exceedingly rare, have been reported: melanocytes 'may' pullulate within the dermo-epidermal foci of malignant epithelial cells.

[Cutaneous-pulmonary sarcoidosis. Diagnostic difficulties in the Black African milieu].

About a case of pulmonary and dermatologic manifestations of sarcoidosis, in a Black African patient, the authors emphasize the clinical polymorphism of sarcoidosis. They insist on the diagnostic criteria of sarcoidosis which are not at all specific of the disease but necessitate a compatible interpretation; particularly in Black Africa where leprosy, tuberculosis and many others granulomatous diseases are endemic.

Histopathological aspects of myiasis.

Myiasis, a rare infestation caused by mainly tropical fly larvae, is now more often encountered in Europe, because of the increasing intercontinental trips. A recent case allowed us to study some anatomopathological and entomological aspects of the African fly maggot.

Dermatofibrosarcoma protuberans: ultrastructural investigation.

The ultrastructural aspects of nucleus and cytoplasm of tumor cells and the interstitial material of dermatofibrosarcoma protuberans are described in detail, especially the very peculiar labyrinthic nucleus. Opinions about its development are reviewed; some, such as melanocytic, neural, histiocytic and smooth muscle proliferation, might be discarded. The myofibroblast appears as the most probable stem cell.