Publications by authors named "Bouricha Molka"
After more than four decades of assisted reproductive technology (ART) practice worldwide, today more than 60% of women undergoing in vitro fertilization (IVF) treatments fail to become pregnant after the first embryo transfer and nearly 20% of patients are suffering from unexplained recurrent implantation failures (RIFs) and repeated pregnancy loss (RPL). The literature reported different causes of RIF-RPL, mainly multifactorial, endometrial and idiopathic. RIF remains a black box because of the complicated categorization and causes of this physio-pathological dysregulation of implantation and pregnancy process after ovarian stimulation.
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- Growth hormone (GH) and insulin growth factor I (IGF1) play significant roles in improving oocyte quality and maturation, with IGF1 mediating the effects of GH and follicle-stimulating hormone (FSH).
- The cytokine IL-6 is highlighted for its potential impact on IVF outcomes, although research on its role in human oocyte maturation remains inconclusive.
- A study found that higher levels of GH, IGF1, and IL-6 in follicular fluid were associated with better prognosis in IVF, while GH emerged as the strongest predictor of oocyte quality.
[Impact of SARS-CoV-2 on fertility, gametes' quality and Assisted Reproduction Technology].
Gynecol Obstet Fertil Senol
February 2022
Article Synopsis
- The pandemic has led to ART centers temporarily halting activities in March 2020, prompting a reevaluation of how COVID-19 impacts reproduction.
- Research continues to explore how the virus affects gametes, fertility, and pregnancy, with mixed findings regarding female gametes and potential neonatal health threats.
- While men may face more severe symptoms and potential impacts on sperm production, the overall effects of COVID-19 on ART practices require further investigation.