Measuring residual anti-Xa activity of direct factor Xa inhibitors after reversal with andexanet alfa.

Introduction: Andexanet alfa (AnXa) was developed for anticoagulant effect reversal of direct factor Xa inhibitors (DXaI) (apixaban, rivaroxaban, edoxaban) in emergency situations. Regular anti-Xa assays are not suitable to evaluate anti-Xa activity after AnXa administration because of the high sample dilution resulting in the AnXa-DXaI dissociation which gives inaccurately high DXaI measured concentrations. This study aimed at developing dedicated STA-Liquid anti-Xa test set-ups for accurately measuring DXaI after reversal with AnXa.

Non-oxidative Energy Supply Correlates with Lactate Transport and Removal in Trained Rowers.

This study aimed to test if the non-oxidative energy supply (estimated by the accumulated oxygen deficit) is associated with an index of muscle lactate accumulation during exercise, muscle monocarboxylate transporter content and the lactate removal ability during recovery in well-trained rowers. Seventeen rowers completed a 3-min all-out exercise on rowing ergometer to estimate the accumulated oxygen deficit. Blood lactate samples were collected during the subsequent passive recovery to assess individual blood lactate curves, which were fitted to the bi-exponential time function: La(t)= [La](0)+A·(1-e )+A·(1-e ), where the velocity constants γ and γ (min) denote the lactate exchange and removal abilities during recovery, respectively.

Factors of Rowing Ergometer Performance in High-Level Female Rowers.

The present study investigated morphological and physiological factors of rowing ergometer performance over 2000 m (P W) in 70 national and international level [27 lightweight (LW) and 43 heavyweight (HW)] female rowers. Maximal oxygen uptake (V̇O, L.min), maximal aerobic power (Pa, W), power output corresponding to 4 mmol.

Muscle MCT4 Content Is Correlated with the Lactate Removal Ability during Recovery Following All-Out Supramaximal Exercise in Highly-Trained Rowers.

The purpose of this study was to test if the lactate exchange (γ1) and removal (γ2) abilities during recovery following short all-out supramaximal exercise correlate with the muscle content of MCT1 and MCT4, the two isoforms of the monocarboxylate transporters family involved in lactate and H(+) co-transport in skeletal muscle. Eighteen lightweight rowers completed a 3-min all-out exercise on rowing ergometer. Blood lactate samples were collected during the subsequent passive recovery to assess an individual blood lactate curve (IBLC).

Similar levels of pain are reported in forefoot surgery after management as a day case and admission for 48 hours: A continuous prospective study of 317 patients.

While many forefoot procedures may be performed as a day case, there are no specific guidelines as to which procedures are suitable. This study assessed the early post-operative pain after forefoot surgery performed a day case, compared with conventional inpatient management. A total of 317 consecutive operations performed by a single surgeon were included in the study.

Factors affecting the energy cost of level running at submaximal speed.

Metabolic measurement is still the criterion for investigation of the efficiency of mechanical work and for analysis of endurance performance in running. Metabolic demand may be expressed either as the energy spent per unit distance (energy cost of running, C r) or as energy demand at a given running speed (running economy). Systematic studies showed a range of costs of about 20 % between runners.

Comparison of quality of life following total ankle arthroplasty and ankle arthrodesis: Retrospective study of 54 cases.

Introduction: The benefit of ankle arthroplasty compared to arthrodesis continues to be debated, but the quality of life after these two interventions has rarely been assessed. We conducted a case-control study to compare quality of life and functional and athletic ability.

Hypothesis: Functional results, athletic ability, and quality of life after total ankle arthroplasty (TAA) are better than after ankle arthrodesis.

A new approach to quantifying physical demand in rugby union.

The objective of the study was to describe an original approach to assessing individual workload during international rugby union competitions. The difference between positional groups and between the two halves was explored. Sixty-seven files from 30 French international rugby union players were assessed on a computerised player-tracking system (Amisco Pro(®), Sport Universal Process, Nice, France) during five international games.

Differences in lactate exchange and removal abilities between high-level African and Caucasian 400-m track runners.

The present study aimed to investigate (1) whether high-level 400-m track runners of different ethnic origin displayed divergent post-run blood lactate concentrations (p400m[La]) and (2) if this discrepancy was based on differences in lactate exchange and removal abilities. Twenty male African (n = 12) and Caucasian (n = 8) runners, paired in terms of personal record, performed (1) an all-out 400-m run to measure p400m[La] at 3, 5 and 7 min into recovery and (2) a 1-min 25.2 km h(-1) running (not maximal but standardized) exercise followed by 90-min passive recovery to determine individual blood lactate recovery curves (IBLRC).

Mechanical determinants of 100-m sprint running performance.

Sprint mechanics and field 100-m performances were tested in 13 subjects including 9 non-specialists, 3 French national-level sprinters and a world-class sprinter, to further study the mechanical factors associated with sprint performance. 6-s sprints performed on an instrumented treadmill allowed continuous recording of step kinematics, ground reaction forces (GRF), and belt velocity and computation of mechanical power output and linear force-velocity relationships. An index of the force application technique was computed as the slope of the linear relationship between the decrease in the ratio of horizontal-to-resultant GRF and the increase in velocity.

Lactate accumulation in response to supramaximal exercise in rowers.

The aim of this study was to test (a) three methods to estimate the quantity of lactate accumulated (QLaA ) in response to supramaximal exercise and (b) correlations between QLaA and the nonoxidative energy supply assessed by the accumulated oxygen deficit (AOD). Nine rowers performed a 3-min all-out test on a rowing ergometer to estimate AOD and lactate accumulation in response to exercise. Peak blood lactate concentration [(La)peak ] during recovery was assessed, allowing QLaA(m1) to be estimated by the method of Margaria et al.

[Cultural competence in the healthcare relationship with migrant patients].

The nursing encounter in an intercultural context focuses on culture as a central element of the healthcare relationship. Learning cultural competence enables nurses to understand others without stigmatizing them.

Throwing performance is associated with muscular power.

The aim of the present study was to test the hypothesis that performance in throwing events is associated with muscular characteristics of both upper and lower limbs. Thirty-eight male throwers volunteered to participate. Bench press and half squat tests were conducted on a guided barbell.

A virtual model of the bench press exercise.

The objective of this study was to design and validate a three degrees of freedom model in the sagittal plane for the bench press exercise. The mechanical model was based on rigid segments connected by revolute and prismatic pairs, which enabled a kinematic approach and global force estimation. The method requires only three simple measurements: (i) horizontal position of the hand (x(0)); (ii) vertical displacement of the barbell (Z) and (iii) elbow angle (theta).

Physiological correlates of performance. Case study of a world-class rower.

This report describes the changes in physiological capacity of a heavy-weight rower who obtained seven medals in World Championships and Olympic Games. The investigation was carried out over the last 6 years of the rower's international competition career in comparison with peer champions, and the following 4 years. Over the first period, maximal oxygen uptake (VO(2max)) remained above 6 l min(-1) which is an outstanding value.

Importance of upper-limb inertia in calculating concentric bench press force.

The purpose of this study was to investigate the influence of upper-limb inertia on the force-velocity relationship and maximal power during concentric bench press exercise. Reference peak force values (Fpeakp) measured with a force plate positioned below the bench were compared to those measured simultaneously with a kinematic device fixed on the barbell by taking (Fpeakt) or not taking (Fpeakb) upper-limb inertia into account. Thirteen men (27.

Bilateral cochlear implantation in a patient with long-term deafness.

Purpose Of The Study: 1) To report the case of a 70-year-old patient with a history of auditory deprivation for 80% of his life and who received bilateral cochlear implants and 2) to discuss different aspects of the case, including duration of auditory deprivation, the decision for bilateral implantation, age at implantation, and the use of this treatment modality for tinnitus.

Case Report: A two-stages bilateral cochlear implantation was performed in a 70-year-old patient with long-term deafness without operative or post-operative problems with excellent functional result.

Discussion: Various studies have reported that in patients with long-term auditory deprivation, the results of cochlear implants are delayed and sometimes unsatisfactory when compared to patients with more recent post-lingual deafness.

The leveling-off of oxygen uptake is related to blood lactate accumulation. Retrospective study of 94 elite rowers.

To assess whether the ability to demonstrate a plateau in oxygen consumption VO2 could be related to adaptation to exercise, the data obtained over a period of 10 years on 94 elite oarsmen who had participated in annual testing were re-evaluated. The test consisted in an incremental step protocol until volitional exhaustion. VO2, heart rate (HR), blood lactate ([La]b) and respiratory exchange ratio (RER) were measured at each step.

Blood lactate and heat stress during training in rowers.

The purpose of the present study was to test the hypothesis that large increases in blood lactate concentration ([La] (b)) and/or body temperature may occur during an endurance training on a rowing ergometer and disrupt training. The influence of an increase in air convection on the capacity to perform a prolonged exercise was also explored. Ten trained oarsmen were asked to undergo twice, in control (C) and increased air ventilation (AV) conditions, two 30-min trainings on a rowing ergometer at a work rate corresponding to 2.

Influence of maxillary mouthguards on physiological parameters.

Introduction: The purpose of this study was to test the influence of two types of maxillary mouthguards (a self-adapted and a custom-made model: SA and CM, respectively) on various physiological parameters generally associated with performance in team sports.

Methods: Nineteen trained male subjects participating in team sports were tested. Visual reaction time, explosive power, ventilation at rest, and ventilation and oxygen consumption during submaximal and maximal exercise were measured in three randomized conditions: normal, with SA mouthguards, or with CM mouthguards.

Torque and power-velocity relationships in cycling: relevance to track sprint performance in world-class cyclists.

The aims of the present study were both to describe anthropometrics and cycling power-velocity characteristics in top-level track sprinters, and to test the hypothesis that these variables would represent interesting predictors of the 200 m track sprint cycling performance. Twelve elite cyclists volunteered to perform a torque-velocity test on a calibrated cycle ergometer, after the measurement of their lean leg volume (LLV) and frontal surface area (A(p)), in order to draw torque- and power-velocity relationships, and to evaluate the maximal power (P(max)), and both the optimal pedalling rate (f(opt)) and torque (T(opt)) at which P (max) is reached. The 200 m performances--i.