Spontaneous abortion is associated with differentially expressed angiogenic chemokines in placenta and decidua.

Purpose: Miscarriage is one of the most common complications of pregnancy. Although chromosomal abnormalities of the embryo is a well-known cause of miscarriage, a lot of cases remain unexplained, with immunologic and vascular growth alterations being considered as probable causes. Chemokines are produced by a variety of cells and exhibit several functions including both pro and anti-angiogenic properties.

Imbalance of growth factors mRNA expression associated with oxidative stress in the early pregnancy loss.

Objective: The aim of this study was to examine the role of growth factors associated with angiogenesis and oxidative stress in the pathogenesis of spontaneous miscarriage.

Methods: We performed a comparative mRNA expression analysis of VEGF, PlGF, Flt-1, Angiogenin and Endoglin using Real-Time PCR, in the placenta and decidua collected from 12 patients presenting with spontaneous abortion and from 14 women undergoing induced abortion, during the first and second trimester of pregnancy.

Results: The mRNA expression of Flt-1 was significantly upregulated in the placenta of spontaneous abortions (5.