Prioritisation of infectious diseases from a public health perspective: a multi-criteria decision analysis study, France, 2024.

BackgroundWithin the International Health Regulations framework, the French High Council for Public Health was mandated in 2022 by health authorities to establish a list of priority infectious diseases for public health, surveillance and research in mainland and overseas France.AimOur objective was to establish this list.MethodsA multi-criteria decision analysis was used, as recommended by the European Centre for Disease Prevention and Control.

Pristine MXene: In Situ XRD Study of MAX Phase Etching with HCl+LiF Solution.

Many applications are suggested for Ti-MXene motivating strong interest in studies of TiCT synthesis by solution-based methods. However, so far only ex situ studies of the synthesis are performed, mostly due to the difficulty of handling HF-based solutions. Here the first time-resolved in situ synchrotron radiation X-ray Diffraction study of MXene synthesis performed using a plastic capillary-size reaction cell directly in HF solution is reported.

Detection of Borrelia burgdorferi sensu lato by proteomics: a complementary diagnosis tool on erythema migrans biopsies.

Objectives: We have developed targeted proteomics in the context of Lyme borreliosis (LM) as a new direct diagnostic tool for detecting Borrelia proteins in the skin of patients with erythema migrans. If satisfactory, this proteomic technique could be used in addition to culture and/or PCR for disseminated infections where Borrelia detection is essential to demonstrate active infection. In these infections, the diagnosis is indirect and relies mainly on serology.

Ticks and tick-borne pathogens on Belle-Île-en-Mer: An exploratory study in a western French island environment.

The islands of Brittany provide unique ecosystems for ticks and tick-borne diseases owing to their oceanic climate, influencing interactions among ticks, hosts, and pathogens. We conducted a preliminary investigation on Belle-Île-en-Mer, an island off the Atlantic coast of Brittany in western France, to assess the prevalence of questing adult ticks and associated human pathogenic bacteria. Dermacentor spp.

Oscillating Structural Transformations in the Electrochemical Synthesis of Graphene Oxide from Graphite.

Electrochemical synthesis of graphene oxide (GO) is known to occur with potential oscillations, but the structural changes underlying these oscillations have remained unclear. In situ time-resolved synchrotron radiation X-ray diffraction demonstrates that the electrochemical synthesis of GO in aqueous HSO can be described as an oscillating reaction. The transformation from graphite to GO proceeds through periodic structural oscillations that correlate with potential cycles.

bites promote allergic skin inflammation and intestinal tuft and mast cell expansion in mice.

Background: Tick bites often promote local allergic reactions in the skin and predispose to red meat allergy. The mechanisms involved in these processes are not fully understood. Here we investigated the local changes to the skin and intestine induced by tick bites.

HOPE Mitigates Ischemia-Reperfusion Injury in Ex-Situ Split Grafts: A Comparative Study With Living Donation in Pediatric Liver Transplantation.

Optimizing graft preservation is key for ex-situ split grafts in pediatric liver transplantation (PSLT). Hypothermic Oxygenated Perfusion (HOPE) improves ischemia-reperfusion injury (IRI) and post-operative outcomes in adult LT. This study compares the use of HOPE in ex-situ partial grafts to static cold storage ex-situ partial grafts (SCS-Split) and to the gold standard living donor liver transplantation (LDLT).

Right Ex-situ split grafts for adult liver transplantation - A Multicenter Benchmarking Analysis.

Objective: To analyse outcomes after adult right ex-situ split graft liver transplantations (RSLT) and compare with available outcome benchmarks from whole liver transplantation (WLT).

Summary Background Data: Ex-situ SLT may be a valuable strategy to tackle the increasing graft shortage. Recently established outcome benchmarks in WLT offer a novel reference to perform a comprehensive analysis of results after ex-situ RSLT.

Resonance tuning of rhythmic movements is disrupted at short time scales: A centrifuge study.

The human body exploits its neural mechanisms to optimize actions. Rhythmic movements are optimal when their frequency is close to the natural frequency of the system. In a pendulum, gravity modulates this spontaneous frequency.

Predictors of clinical deterioration and intensive care unit admission in trauma patients transferred from northern Quebec to a level 1 trauma centre: a retrospective cohort study.

Background: Trauma care in Nunavik, Quebec, is highly challenging. Geographic distances and delays in transport can translate into precarious patient transfers to tertiary trauma care centres. The objective of this study was to identify predictors of clinical deterioration during transport and eventual intensive care unit (ICU) admission for trauma patients transferred from Nunavik to a tertiary trauma care centre.

Lung cancer in Nunavik: How are we doing? A retrospective matched cohort study.

Background: Whether Inuit in Canada experience disparities in lung cancer survival remains unknown. When requiring investigation and treatment for lung cancer, all residents of Nunavik, the Inuit homeland in Quebec, are sent to the McGill University Health Centre (MUHC), in Montréal. We sought to compare survival among patients with lung cancer at the MUHC, who were residents of Nunavik and Montréal, Quebec, respectively.

Surgical, trauma and telehealth capacity in Indigenous communities in Northern Quebec: a cross-sectional survey.

Background: Delivering trauma and surgical care to Northern Quebec presents unique challenges owing to the region's remoteness, extreme weather and limited transport; the expansion of telehealth could help address these difficulties. We aimed to evaluate current surgical, trauma and telemedicine capacity in Nunavik, Quebec.

Methods: We used validated assessment tools, including the Personnel, Infrastructure, Procedures, Equipment and Supplies survey, the International Assessment of Capacity for Trauma index and the Maryland Health Care Commission Telemedicine Readiness tool to evaluate surgical, trauma and telemedicine capacity, respectively.

Cross-alteration of murine skin and tick microbiome concomitant with pathogen transmission after Ixodes ricinus bite.

Background: Ticks are major vectors of diseases affecting humans such as Lyme disease or domestic animals such as anaplasmosis. Cross-alteration of the vertebrate host skin microbiome and the tick microbiome may be essential during the process of tick feeding and for the mechanism of pathogen transmission. However, it has been poorly investigated.

Vaccines against tick-borne diseases: a big step forward?

Ticks and tick-borne diseases are on the rise due to socioecosystemic changes and climate modification and are affecting human and animal health. Few vaccines are available. Two recent articles from Matias et al.

Skin microbiota secretomes modulate cutaneous innate immunity against Borrelia burgdorferi s.s.

In Lyme borreliosis, the skin constitutes a major interface for the host, the bacteria and the tick. Skin immunity is provided by specialized immune cells but also by the resident cells: the keratinocytes and the fibroblasts. Discoveries on the role of the microbiome in the modulation of skin inflammation and immunity have reinforced the potential importance of the skin in vector-borne diseases.

[Anthropization and tick-borne diseases: the example of Lyme borreliosis].

Ticks and tick-borne diseases are on the rise throughout the world. The reasons are multifactorial but all associated with human practices, including climate change and socio-economic and eco systemic changes. In the northern hemisphere, Lyme borreliosis and its vector, the tick belonging to the Ixodes ricinus complex, are particularly studied.

Scalable production of foam-like nickel-molybdenum coatings plasma spraying as bifunctional electrocatalysts for water splitting.

Foam-like NiMo coatings were produced from an inexpensive mixture of Ni, Al, and Mo powders atmospheric plasma spraying. The coatings were deposited onto stainless-steel meshes forming a highly porous network mainly composed of nanostructured Ni and highly active NiMo. High material loading (200 mg cm) with large surface area (1769 cm per cm) was achieved without compromising the foam-like characteristics.

Super-oxidized "activated graphene" as 3D analogue of defect graphene oxide: Oxidation degree vs U(VI) sorption.

Porous carbons are not favorable for sorption of heavy metals and radionuclides due to absence of suitable binding sites. In this study we explored the limits for surface oxidation of "activated graphene" (AG), porous carbon material with the specific surface area of ∼2700 m/g produced by activation of reduced graphene oxide (GO). Set of "Super-Oxidized Activated Graphene" (SOAG) materials with high abundance of carboxylic groups on the surface were produced using "soft" oxidation.

Activated carbons with extremely high surface area produced from cones, bark and wood using the same procedure.

Activated carbons have been previously produced from a huge variety of biomaterials often reporting advantages of using certain precursors. Here we used pine cones, spruce cones, larch cones and a pine bark/wood chip mixture to produce activated carbons in order to verify the influence of the precursor on properties of the final materials. The biochars were converted into activated carbons with extremely high BET surface area up to ∼3500 m g (among the highest reported) using identical carbonization and KOH activation procedures.