Publications by authors named "Bouiller K"
Linezolid in enterococcal urinary tract infection: a multicentre study.
Eur J Clin Microbiol Infect Dis
November 2024
Purpose: Few data have been published on the efficacy of linezolid in enterococcal urinary tract infection (e-UTI). The aims of this study were to describe the characteristics of patients with enterococci UTI treated with linezolid, and to evaluate the efficacy and the tolerance of linezolid treatment.
Methods: An observational multicentre retrospective study was conducted in 5 hospitals in France.
Background: Systematic treatment with intravenous acyclovir is usually given when varicella zoster virus (VZV) DNA is isolated in cerebrospinal fluid (CSF), indicating central nervous system (CNS) involvement. Our study aimed to describe therapeutic management and acute kidney injury (AKI) occurrence during acyclovir treatment of VZV infection with CNS involvement.
Methods: Multicentre, retrospective study including all patients from 2010 to 2022 with VZV DNA in CSF.
Article Synopsis
- A study examined patients with unexplained neurological symptoms and suspected Lyme neuroborreliosis (LNB) by comparing characteristics of those with and without LNB.
- Out of 155 patients, 29% were diagnosed with LNB, with key findings indicating certain neurological symptoms like facial nerve palsy and shorter duration of symptoms linked to LNB.
- Many patients, regardless of LNB diagnosis, reported similar non-neurological symptoms, suggesting that over a quarter of those seeking care had conditions unrelated to LNB.
Prevalence of kidney stones is increasing worldwide, flexible ureterorenoscopy (f-URS) is the most common surgical treatment. Postoperative urinary tract infection (PUTI) is the primary complication. Some risk factors are classically associated with PUTI, especially preoperative positive urinalysis (POPU).
View Article and Find Full Text PDFBackground: We aimed to compare patient characteristics, MRSA sequence types, and biofilm production of MRSA strains that did and did not cause a foreign body infection in patients with MRSA bloodstream infections (BSI).
Methods: All adult patients with MRSA BSI hospitalized in two hospitals were identified by clinical microbiology laboratory surveillance. Only patients who had at least one implanted foreign body during the episode of BSI were included.
Objectives: French healthcare students are required to carry out primary prevention interventions as part of the Healthcare Service by Healthcare Students (HSHS). The purpose of this study was to explore students' perceptions of preparedness to address the public's concerns about antibiotic use and how their perceptions changed after implementing their intervention.
Methods: A questionnaire was sent twice during the 2020-2021 academic year to 920 multidisciplinary healthcare students (nursing, medicine, physiotherapy, pharmacy and midwifery students) enrolled in the HSHS in Franche-Comté (HSHS-FC).
Article Synopsis
- The study aimed to assess how switching from ceftriaxone to cefotaxime affects the rates of third-generation cephalosporin-resistant Enterobacterales (3GC-RE).
- Conducted over 24 months, the trial compared a control phase (where both antibiotics were used) to an intervention phase (where only cefotaxime was prescribed).
- Results showed a decrease in 3GC-RE incidence during the intervention phase, suggesting that cefotaxime may be more effective in reducing these resistant infections, although further research is necessary to validate these findings.
Background: Using genomic data, we determined the origin of MRSA ST398 isolates responsible for invasive infection in patients with no known livestock contact.
Methods: We sequenced the genome of seven MSSA and four MRSA ST398 isolates from patients with invasive infections between 2013 and 2017, using the Illumina technique. Prophage-associated virulence genes and resistance genes were identified.
Introduction: During infected total hip arthroplasty revisions (THAR), the need for systematic antibiotic cementation remains undefined.
Hypothesis: Implantation of a primary cementless stem as first-line implant in 1-stage septic THAR provides results as good as those from a stem cemented with antibiotics in terms of infection resolution.
Materials And Methods: We retrospectively examined 35 patients operated on for septic THAR with Avenir® cementless stem placement - between 2008 and 2018 at Besançon University Hospital - with a minimum follow-up of 2 years to define healing in the absence of infectious recurrence.
Article Synopsis
- * Out of 663 patients, 48 (7.24%) developed FUSAUTI, with a notable number experiencing severe complications like sepsis. Common bacteria involved included E. coli and Enterococcus.
- * Key risk factors for developing FUSAUTI included being female, having multiple health issues, undergoing urethral stent placement alongside ureteral stent insertion, and a recent history of urinary infections; only urethral stent placement was identified as a modifiable risk factor.
Article Synopsis
- A systematic review of studies published between January 2000 and October 2022 analyzed the genetic factors influencing outcomes in patients with various bone and joint infections (BJIs), including prosthetic joint infections and osteomyelitis.
- The review included 34 articles, with findings indicating that certain genes, such as Panton Valentine leucocidin (PVL) in children, were linked to more severe infections and worse clinical outcomes, while adult studies showed varied and sometimes contradictory associations.
- The authors concluded that further research with larger and more uniform study populations is necessary to better understand the genetic impacts on BJI outcomes.
Article Synopsis
- The study investigated the characteristics, management, and residual symptoms in patients diagnosed with Lyme neuroborreliosis (LNB) over a decade in France, focusing on both definite and possible cases.
- Out of 138 adult patients, those with definite LNB showed shorter symptom duration and higher rates of radicular pain compared to those with possible LNB.
- At follow-up, 59.7% of patients reported residual symptoms, with early diagnosis and treatment identified as critical for better outcomes and reducing long-term effects.
Introduction: Data on infections associated with cerebrospinal fluid shunt (CSF-S) or device-associated infection (CSF-SDI) are limited in adults. We performed a retrospective study to describe characteristics, management, and outcome of CSF-SDI.
Methods: All patients with CSF-SDI and admitted to our institution from January 2013 to December 2019 were included.
Objective: The aim of our study was to describe the 2021 Hemorrhagic Fever with Renal Syndrome (HFRS) outbreak in the southern Jura Mountains.
Patients And Methods: We included all laboratory-confirmed cases of HFRS reported between April and September 2021 in the three local hospitals.
Results: A total of 90 patients were enrolled in the study: 73 hospitalized and 17 non-hospitalized patients.
Article Synopsis
- A study was conducted to assess the prevalence and factors related to nasal carriage of the bacterium CC398 in healthy blood donors and hospitalized patients at a French university hospital.
- Results showed that the prevalence of CC398 was higher among healthy blood donors (7.3%) compared to hospitalized patients (3.8%), with a notable absence of MRSA strains.
- Factors like prior antibiotic use and active smoking increased the likelihood of nasal carriage in healthy individuals, while older age and a history of neurological disease were associated with carriage in hospitalized patients; overall, no environmental sources were identified as risk factors.
Article Synopsis
- The study investigated the prevalence and characteristics of sleep apnea (SA) in patients who were hospitalized in the ICU for severe COVID-19, focusing on their apnea hypopnea index (AHI) three months post-illness.
- Out of 68 patients, a staggering 91% developed SA, with 44 individuals experiencing moderate to severe cases, while 62% of patients had other health issues, like obesity and hypertension.
- The findings emphasize the need for sleep assessments after ICU care for COVID-19, as those with moderate to severe SA had more severe COVID-19 symptoms and longer hospital stays.
Article Synopsis
- The study looked at how infective endocarditis (IE) affects pregnant women who don’t use drugs and included cases from 14 hospitals over many years.
- Most women in the study were around 33 years old and had their babies about 30 weeks along; many had no prior heart issues.
- Most women faced serious problems, like heart failure and complications with their pregnancies, including some that resulted in surgery or even loss of the baby; one woman sadly died from the illness.
Long-term evolution data of olfactory disorders (OD) in COVID-19 are limited. ANOSVID is a retrospective study in Nord Franche-Comté Hospital (France) that included COVID-19 patients from the first wave. The aim was to describe OD evolution, especially in patients with persistent OD (p-OD group) in comparison with patients with resolved OD (r-OD group).
View Article and Find Full Text PDFTo describe the number of prosthetic joint infections (PJIs) with late documentation and to identify associated factors. Bacterial PJIs with surgical management between November 2015 and November 2019 in a French center were analyzed. Results of short (72 h) and late culture (at 14 days) were analyzed.
View Article and Find Full Text PDFOlfactory disorders (OD) pathogenesis, underlying conditions, and prognostic in coronavirus disease 2019 (COVID-19) remain partially described. ANOSVID is a retrospective study in Nord Franche-Comté Hospital (France) that included COVID-19 patients from March 1 2020 to May 31 2020. The aim was to compare COVID-19 patients with OD (OD group) and patients without OD (no-OD group).
View Article and Find Full Text PDFObjectives: Nocardiosis is a rare opportunistic infection that is frequently associated with dissemination (i.e. involvement of several body sites).
View Article and Find Full Text PDFArticle Synopsis
- Lymphopenia, a condition where lymphocyte (a type of white blood cell) levels are low, is often found in sepsis patients and is linked to higher mortality rates.
- The study examined if lymphopenia could be a reliable indicator of outcomes in patients with bacteremia, involving 574 individuals from two hospitals.
- Results showed that initial lymphocyte counts and changes over the first four days did not predict 12-week mortality, suggesting the need for a better understanding of each patient’s immune profile before pursuing immune therapies.
To evaluate the role and perceptions of trainees during the COVID-19 pandemic. An online survey was designed to provide an insight into the significance of the COVID-19 pandemic on working conditions of infectious diseases and clinical microbiology trainees. The main roles of trainees included management of patients hospitalized for COVID-19 (55%), research (53%) and diagnostic procedures (43%).
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