Publications by authors named "Boufersaoui A"
Article Synopsis
- Tumor cells can adapt to a lack of amino acids by changing their metabolism, using alternative sources like glutamate when deprived of asparagine and glutamine due to L-asparaginase (ASNase) treatment.
- ASNase's effectiveness relies on inducing nutrient stress that raises serum levels of aspartate and glutamate while depleting asparagine and glutamine in acute lymphoblastic leukemia patients.
- Increased glutamate uptake helps cancer cells survive by supporting critical metabolic processes like nucleotide and glutathione synthesis, suggesting that inhibiting glutamate transporters could improve the efficacy of ASNase treatment.
Article Synopsis
- T cells undergo metabolic changes upon activation to support their growth and function, particularly in chronic inflammatory diseases like rheumatoid arthritis (RA).
- Research shows that tumor necrosis factor-α (TNF-α) released from naïve CD4 T cells triggers metabolic alterations, enhancing processes like glycolysis and amino acid uptake through specific signaling pathways.
- Increased TNF-α production and metabolic reprogramming, driven by ITK and Akt-mTOR signaling, lead to a rise in proinflammatory T cell differentiation in RA patients, indicating a link between inflammatory cytokines and dysregulated metabolism in immune responses.
Article Synopsis
- Scientists used special techniques to study how glucose is used in cells that help control insulin, called β cells, in both mice and humans.
- They discovered that glucose is used similarly in both species, but humans produce much more lactate, which is a waste product.
- A specific protein called LDHB helps control how much lactate these cells make, and lower levels of this protein are linked to higher insulin levels in humans.
Introduction: Inborn errors of immunity (IEI) represent a heterogeneous large group of genetic disorders characterized by susceptibility of affected individuals to recurrent infections, autoimmune/inflammatory diseases, allergy, and malignancy. We aimed to report for the first time the Algerian registry for IEI in children.
Methods: We described the characteristics of IEI in Algerian children from the data collected in the Algerian registry for IEI between 1985 and 2021.
The mitochondrial citrate transport protein (CTP), encoded by SLC25A1, accommodates bidirectional trafficking of citrate between the mitochondria and cytosol, supporting lipid biosynthesis and redox homeostasis. Genetic CTP deficiency causes a fatal neurodevelopmental syndrome associated with the accumulation of L- and D-2-hydroxyglutaric acid, and elevated CTP expression is associated with poor prognosis in several types of cancer, emphasizing the importance of this transporter in multiple human pathologies. Here we describe the metabolic consequences of CTP deficiency in cancer cells.
View Article and Find Full Text PDFForeign body aspiration in children: experience from 2624 patients.
Int J Pediatr Otorhinolaryngol
October 2013
Objectives: The objective of this study is to analyze the epidemiological, clinical, radiological and endoscopic characteristics of pediatric foreign body aspiration in Algeria.
Methods: In this retrospective study, the results of 2624 children younger than 18 years admitted in our department for respiratory foreign body removal between 1989 and 2012, were presented. Most of them had an ambulatory rigid bronchoscopy.