Postoperative Radiotherapy for pT1- and pT2-Classified Squamous Cell Carcinoma of the External Auditory Canal.

Background: There is no consensus regarding the indication for postoperative radiotherapy (PORT) for T1- and T2-classified squamous cell carcinoma (SCC) of the external auditory canal (EAC) even with negative surgical margins. This study aimed to evaluate whether PORT provides additional benefits for these cases.

Methods: We collected retrospective data from fourteen international hospitals, including resected pT1- and pT2-classified EAC SCC with negative surgical margins.

Comparison of postural control and space perception outcomes between robotic and conventional cochlear implantation in adults.

Purpose: The aim of the study is to capture the difference between the groups in direct relation to the type of electrode array insertion during cochlear implantation (CI). The robotic insertion is expected to be a more gently option. As recent studies have shown, there is a difference in perception of visual vertical (SVV) and postural control related to the CI.

Tissue contexture determines the pattern and density of tumor-infiltrating immune cells in HPV-associated squamous cell carcinomas of oropharynx and uterine cervix.

The profile of the antitumor immune response is an important factor determining patient clinical outcome. However, the influence of the tissue contexture on the composition of the tumor microenvironments of virally induced tumors is not clearly understood. Therefore, we analyzed the immune landscape of two HPV-associated malignancies: oropharyngeal squamous cell carcinoma (OPSCC) and squamous cell carcinoma of uterine cervix (CESC).

The impact of the application of compochar on soil moisture, stress, yield and nutritional properties of legumes under drought stress.

Nowadays, when climate change is becoming more and more evident, drought stress plays a very important role, including in agriculture. The increasing number of years with extreme temperatures in the Czech Republic has a negative impact on agricultural production, among other things. Therefore, ways are being sought to reduce these negative impacts.

High incidence of occult familial cases amongst Czech patients with head and neck paragangliomas.

Introduction: Head and neck paragangliomas (HNPGLs) are rare neuroendocrine tumors, which are mostly benign in nature. Amongst all genes, Succinate Dehydrogenase Subunit D () is the most commonly mutated in familial HNPGLs. In about 30% of HNPGLs, germline mutations in can also occur in the absence of positive family history, thus giving rise to "occult familial" cases.

Subjective visual vertical and postural control in patients following cochlear implantation.

Background: Cochlear implantation (CI) is associated with changes in the histopathology of the inner ear and impairment of vestibular function.

Objective: The objectives of our study were to evaluate patients for clinical manifestations of space perception and balance changes before surgery, compare them with asymptomatic subjects (controls), and report changes in posturography and subjective visual vertical (SVV) during the acute post-surgery period in patients.

Methods: Examination was performed using static posturography and the SVV measurement.

Stimuli-Responsive Polymer Nanoprobes Intended for Fluorescence-Guided Surgery of Malignant Head-and-Neck Tumors and Metastases.

Nano-sized carriers are widely studied as suitable candidates for the advanced delivery of various bioactive molecules such as drugs and diagnostics. Herein, the development of long-circulating stimuli-responsive polymer nanoprobes tailored for the fluorescently-guided surgery of solid tumors is reported. Nanoprobes are designed as long-circulating nanosystems preferably accumulated in solid tumors due to the Enhanced permeability and retention effect, so they act as a tumor microenvironment-sensitive activatable diagnostic.

Chemical pulp from corn stalks.

This work aimed to carry out chemical cooking of corn stalks, both in a nitrate-alkaline manner and in a soda pulp method. The composition of corn is characterized by cellulose, lignin, ash, and substances extractable into polar and organic solvents. Handsheets were made from the pulp, for which the degree of polymerization, sedimentation rate, and strength properties was determined.

Biochar in manure can suppress water stress of sugar beet (Beta vulgaris) and increase sucrose content in tubers.

Increased soil drought events threaten the yields of sugar beet (Beta vulgaris L.) and other staples of arable production in central Europe. In this study we evaluated soil moisture and nutrients as impacted by a two and five % (wt) addition of biochar, manure and their blend to a loamy-sand Regosol.

Synthesis of human amyloid restricted to liver results in an Alzheimer disease-like neurodegenerative phenotype.

Several lines of study suggest that peripheral metabolism of amyloid beta (Aß) is associated with risk for Alzheimer disease (AD). In blood, greater than 90% of Aß is complexed as an apolipoprotein, raising the possibility of a lipoprotein-mediated axis for AD risk. In this study, we report that genetic modification of C57BL/6J mice engineered to synthesise human Aß only in liver (hepatocyte-specific human amyloid (HSHA) strain) has marked neurodegeneration concomitant with capillary dysfunction, parenchymal extravasation of lipoprotein-Aß, and neurovascular inflammation.

Nitrate-Alkaline Pulp from Non-Wood Plants.

Because there is a lack of wood resources in many countries, this work focused on pulp and paper production from the waste and agricultural residues of non-wood plants. The work aimed to pulp the nitrate-alkaline of black mustard ( L.) and camelina ( L.

Flammability Characteristics of Thermally Modified Meranti Wood Treated with Natural and Synthetic Fire Retardants.

This paper deals with the effect of synthetic and natural flame retardants on flammability characteristics and chemical changes in thermally treated meranti wood ( spp.). The basic chemical composition (extractives, lignin, holocellulose, cellulose, and hemicelluloses) was evaluated to clarify the relationships of temperature modifications (160 °C, 180 °C, and 210 °C) and incineration for 600 s.

Physicochemical Properties of Biobutanol as an Advanced Biofuel.

Biobutanol is a renewable, less polluting, and potentially viable alternative fuel to conventional gasoline. Biobutanol can be produced from same sources as bioethanol, and it has many advantages over the widespread bioethanol. This paper systematically analyzes biobutanol fuel as an alternative to bioethanol in alcohol-gasoline mixtures and the physicochemical properties.

The cytokine milieu compromises functional capacity of tumor-infiltrating plasmacytoid dendritic cells in HPV-negative but not in HPV-positive HNSCC.

Plasmacytoid dendritic cells (pDCs) are the most potent type I interferon-producing cells and play an important role in antiviral immunity. Tumor-infiltrating pDCs were shown to be predominantly pro-tumorigenic, with reduced ability to produce interferon alpha (IFNα) and confirmed capacity to prime regulatory T cells (Tregs) by the ICOS/ICOS-L pathway. Because a significant number of HNSCCs are induced by human papillomaviruses and show markedly different immune profiles than non-virally induced tumors, we compared the phenotype and functional capacity of HNSCC-infiltrating pDCs to the HPV status of the tumor.

Determination of Tractor Engine Oil Change Interval Based on Material Properties.

This article focuses on the issue of motor oils used in the engines of non-road mobile machinery (NRMM), more specifically tractors. The primary goal of the paper is to determine the appropriate replacement interval for these oils. The physical properties of the examined samples were first determined by conventional instruments.

Differential diagnosis of ear pain.

Ear pain, otalgia, can have many etiologies. Some of these conditions, e.g.

Cochlear Implantation.

Historically, cochlear implants are the first substitute for a sensory modality, hearing. In past decades, they have become a standard method of a compensation for a hearing loss, both for children and adults. Because of restored hearing by cochlear implants, people were able to keep their jobs, marriages and other social ties.

Inner ear disorders.

Auditory part of the inner ear transforms mechanic energy to the electric energy. The key component of this process are hair cells, which damage leads to often irreversible hearing impairment. The damage can occur due to several external and internal causes and the treatment focuses mainly onto the mitigation of the consequences.

Targeted Polymer-Based Probes for Fluorescence Guided Visualization and Potential Surgery of EGFR-Positive Head-and-Neck Tumors.

This report describes the design, synthesis and evaluation of tumor-targeted polymer probes to visualize epidermal growth factor receptor (EGFR)-positive malignant tumors for successful resection via fluorescence guided endoscopic surgery. Fluorescent polymer probes of various molecular weights enabling passive accumulation in tumors via enhanced permeability and retention were prepared and evaluated, showing an optimal molecular weight of 200,000 g/mol for passive tumor targeting. Moreover, poly(-(2-hydroxypropyl)methacrylamide)-based copolymers labeled with fluorescent dyes were targeted with the EGFR-binding oligopeptide GE-11 (YHWYGYTPQNVI), human EGF or anti-EGFR monoclonal antibody cetuximab were all able to actively target the surface of EGFR-positive tumor cells.

The FSHR Expression in Head and Neck Squamous Cell Cancer. A Pilot Immunohistochemical Study.

Background/aim: Follicle-stimulating hormone receptor (FSHr), expressed on endothelial cells of vessels in different malignant tumors, has been recently investigated as a potential pan-receptor of cancer treatment. However, the expression of this receptor has also been confirmed in other tissues under pathological conditions including cancer. The aim of the presented pilot study was to evaluate the expression of FSHr in head and neck squamous cancer (HNSCC).

Micelle-Forming Block Copolymers Tailored for Inhibition of P-gp-Mediated Multidrug Resistance: Structure to Activity Relationship.

Multidrug resistance (MDR) is often caused by the overexpression of efflux pumps, such as ABC transporters, in particular, P-glycoprotein (P-gp). Here, we investigate the di- and tri- block amphiphilic polymer systems based on polypropylene glycol (PPO) and copolymers of (-(2-hydroxypropyl)methacrylamide) (PHPMA) as potential macromolecular inhibitors of P-gp, and concurrently, carriers of drugs, passively targeting solid tumors by the enhanced permeability and retention (EPR) effect. Interestingly, there were significant differences between the effects of di- and tri- block polymer-based micelles, with the former being significantly more thermodynamically stable and showing much higher P-gp inhibition ability.

Tumor-infiltrating B cells affect the progression of oropharyngeal squamous cell carcinoma via cell-to-cell interactions with CD8 T cells.

Background: Standard treatment of oropharyngeal squamous cell carcinoma (OPSCC) is associated with high morbidity, whereas immunotherapeutic approaches using PD-1:PD-L1 checkpoint blockade only show moderate response rates in OPSCC patients. Therefore, a better stratification of patients and the development of novel therapeutic protocols are crucially needed. The importance of tumor-infiltrating B cells (TIL-Bs) in shaping antitumor immunity remains unclear; therefore, we analyzed frequency, phenotype, prognostic value and possible roles of TIL-Bs in OPSCC.

Immunology of Plasmacytoid Dendritic Cells in Solid Tumors: A Brief Review.

The immune response, both innate and adaptive, is a key player in cancer development and progression. Plasmacytoid dendritic cells (pDCs) are a subset of dendritic cells that play one of the central roles in the immune system. They are known mostly as the major IFN type I-producing cells upon stimulation of Toll-like receptors 7 and 9.

The Head and Neck Squamous Cell Carcinoma Microenvironment as a Potential Target for Cancer Therapy.

Similarly to other types of malignant tumours, the incidence of head and neck cancer is increasing globally. It is frequently associated with smoking and alcohol abuse, and in a broader sense also with prolonged exposure to these factors during ageing. A higher incidence of tumours observed in younger populations without a history of alcohol and tobacco abuse may be due to HPV infection.