Publications by authors named "Bouba Gake"
Article Synopsis
- * A study conducted in Cameroon aimed to evaluate the impact of the MenAfriVac intervention by analyzing case data and vaccination records from 2009 to 2015.
- * Results indicated a dramatic decrease in meningitis A cases—from 92 in 2011 to zero by 2014—and estimated the vaccine's effectiveness at 98.63%, confirming its positive impact as expected by the WHO; ongoing surveillance is recommended to address evolving health threats.
In the original publication of this article [1], Table 1 has some errors.
View Article and Find Full Text PDFHere we propose a strategy allowing implementing efficient and practicable large-scale seroepidemiological studies for Zika Virus (ZIKV). It combines screening by a commercial NS1 protein-based Zika IgG ELISA, and confirmation by a cytopathic effect-based virus neutralization test (CPE-based VNT). In post-epidemic samples from Martinique Island blood donors (a population with a dengue seroprevalence above 90%), this strategy allowed reaching specificity and sensitivity values over 98%.
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- - The study focused on the impact of weather conditions like temperature, humidity, and rainfall on the seasonal patterns of influenza viruses in Northern Cameroon, where temperatures are high.
- - Researchers analyzed data from January 2014 to December 2016, using a vector error correction model to connect monthly confirmed influenza cases with the corresponding meteorological data.
- - Results revealed a significant link between humidity levels and overall influenza activity, indicating that higher humidity could lead to increased influenza cases two months later, while temperature and rainfall did not affect influenza B activity.
A Zika virus seroepidemiology study was performed in 1084 blood donors collected from August to October 2015 in six sites of Cameroon representing a large panel of eco-environments. Samples were tested using an anti-NS1 IgG ELISA detection kit and positives were further confirmed by seroneutralization. The observed global seroprevalence was low (around 5%, peaking at 10% and 7.
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- * A rapid diagnostic test (RDT) was developed using antibodies from rabbits immunized with inactivated NmX bacteria, showing high specificity for detecting the NmX capsular polysaccharide.
- * In tests performed on cerebrospinal fluid samples from patients, the RDT demonstrated a sensitivity of 100% and a specificity of 94%, indicating it could effectively enhance meningitis surveillance in regions affected by the disease.
Objectives: Monitoring acute bacterial meningitis in northern Cameroon.
Methods: Health professionals collected cerebrospinal fluid (CSF) specimens from patients presenting with clinical symptoms of meningitis. Specimens were tested using gram stain, latex agglutination test, and culture.
The ability of strains of faecal bacteria (Vibrio cholerae, Escherichia coli ATCC 25922, and four strains of Salmonella isolated, resp., from well water, pig, poultry, and human urine in Garoua) to survive or grow in well water microcosms was compared. Water samples were obtained from two wells in Garoua (north Cameroun).
View Article and Find Full Text PDFHighly pathogenic avian influenza (HPAI) virus was first detected in Cameroon in February 2006. Analysis of NA sequences of the virus demonstrated that it is closely related to the H5N1 isolates from Northern Nigeria, Sudan and Ivory Coast, suggesting a common virus ancestor.
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