Recurrent arginine substitutions in the ACTG2 gene are the primary driver of disease burden and severity in visceral myopathy.

Visceral myopathy with abnormal intestinal and bladder peristalsis includes a clinical spectrum with megacystis-microcolon intestinal hypoperistalsis syndrome and chronic intestinal pseudo-obstruction. The vast majority of cases are caused by dominant variants in ACTG2; however, the overall genetic architecture of visceral myopathy has not been well-characterized. We ascertained 53 families, with visceral myopathy based on megacystis, functional bladder/gastrointestinal obstruction, or microcolon.

[Therapy-resistant periprosthetic abscess of the hip of unknown cause].

Two months after total endoprosthesis of the hip (Spotorno) a 60-year-old obese female patient complained about increasing hip pain. Costly diagnostic measures could not clarify the cause. Analgesic therapy administered with local cortisone injections was not satisfactory.

[Anatomo-clinical features of an erysipeloid form of cutaneous leismaniasis in Tunisia].

The erysipeloid form of cutaneous leishmaniasis is considered as an unusual and rare clinical presentation in Tunisia. Our prospective study on 4 observations, aimed at examining the clinical, histological and progressive features of the "erysipeloid" form of cutaneous leishmaniasis. Our patients were 3 females and one male more than 62 years old.

[Impetigo herpetiformis (two cases)].

Unlabelled: The hepetiformis impetigo is a pustulosis dermatosis. It is rare and specific to pregnancy. It can menace the prognostic of the mother and the child.

[Disseminated cutaneous leishmaniasis secondary to lymphoedema: two cases].

Background: Dissemination of cutaneous leishmaniasis may take various forms: satellite papules, sporotrichoid nodules and widespread papulonodular lesions (disseminated cutaneous leishmaniasis). We describe a particular clinical form of dissemination in two patients with erysipelas secondary to lymphoedema.

Patients And Methods: Case 1.

[Sporotrichoid cutaneous leishmaniasis in Tunisia: a clinical and histological study].

Background: The sporotrichoid variety of cutaneous leishmaniasis is defined by the presence of dermal and hypodermal nodules along the lymphatic stream, and remote from the primary inoculation lesions. This clinical form is usually considered rare. The aim of our study was to investigate the epidemiological, clinical, histological and evolutionary particularities of sporotrichoid cutaneous leishmaniasis in the south of Tunisia.

Acquired lymphangioma circumscriptum of the vulva.

Lymphangiomas are rare benign proliferations of the lymphatic system. Acquired lymphangioma circumscriptum of the vulva is induced by impaired lymph flow. We describe a new case of lymphangioma circumscriptum resulting from tuberculosis involving a lymph node.

[Childhood actinic lichen planus (6 cases)].

Introduction: Actinic lichen planus (ALP) is a chronic and benign disease that affects young people of the Middle East and Maghreb countries.

Purpose: To analyse clinical features and prognosis of ALP in children.

Patients And Methods: A retrospective, descriptive study of cases observed in the department of dermatology of Sfax hospital over a period of 11 years (1995-2005).

[Sexual dysfunction after colostomy].

Background: Sexual disturbances after colostomy are various. However, they probably remain underestimated in societies where sexuality is still a taboo issue. THE AIM of this prospective study was to evaluate the possible sexual behaviour and the post operative sexual disturbances in patients whome underwent colostomy.

[Clinical and histological study of lupoid cutaneous leishmaniasis (16 cases)].

Introduction: Zoonotic cutaneous leishmaniasis (CL) is characterised by a major clinical polymorphism, especially the lupoid type. The aim of our study was to precise the anatomic and clinical particularities of this clinical form of CL.

Materials And Methods: The present work was a prospective 1-year study.

[Epidemio-clinical profile of skin cancer in southern Tunisia].

Background: Skin cancer (SK) frequency is increasing all over the world.

Aim: We report a clinical and epidemiological study of SK in the south of Tunisia through a 1476 cases series.

Method: On the basis of a retrospective study, we report the clinical and epidemiological data collected from files of patients with skin cancers seen during a 24-year-period (1979-2002).

[Clinical polymorphism of cutaneous leishmaniasis in centre and south of Tunisia].

The cutaneous leishmaniasis (CL) is an affection which is quite well known in Tunisia. The zoonotic cutaneous leishmaniasis caused by Leishmania major by far the more frequent, is endemo-epidemic in the centre and south of the country. It is characterized by clinical polymorphism.

[Sweet syndrome: retrospective study of 54 cases].

Introduction: Sweet syndrome is the most common neutrophilic dermatosis. We studied its natural history and epidemiologic, clinical, and therapeutic characteristics from a series of 54 cases.

Materials And Methods: This retrospective study examines 54 cases collected over a 10-year-period.

[Tricho-epithelioma multiplex: two cases reports].

Tricho-epitheliomas are benign tumors of the pilosebaccous apparatus. Multiple tricho-epithelioma form is particular. We report 2 new cases.

[Profile of basal cell carcinomas of the scalp after radiotherapy for tinea capitis (about 63 cases)].

The induction of basal cell carcinoma (BCC) of the scalp by X-ray therapy for tinea capitis is well known. The aim of the study was to specify the epidemiological, clinical and histological characteristics of this disease. In a retrospective study, we collected data from the files of 63 patients, with a history of radiotherapy for tinea capitis, followed between January 1995 and December 2004.

[Subacute cutaneous lupus erythematosus in childhood: a case report].

Subacute cutaneous lupus erythematosus is extremely rare in childhood. We report the case of a 7 year-old girl who presented annular erythematous infiltrated lesions on sun exposed areas since the age of 2 months. Histopathologic examination showed orthohyperkeratosis, epidermal atrophy, widespread hydropic degeneration of epidermal basal cell layer, and a dermal lymphohistiocytic infiltrate.

[Fluconazole and treatment of onychomycosis. About 86 cases].

Systemic treatment of onychomycosis is based these last years on the new drug utilization aiming to decrease the length of the treatment and secondary effects particularly with fluconazole. The aim of our study is to determine the efficiency and the tolerance of the fluconazole (Funzol) managed to the dose of 150 mg per week in the treatment of onychomycosis. It is a multicentric and prospective study done to different department of dermatology in Tunisia.