Immunopotentiation of hepatitis B vaccine using biodegradable polymers as an adjuvant.

Background/purpose: The purpose of this research was to develop an alternative adjuvant for hepatitis B vaccine (HBsAg) that elicits a long-lasting immune response after a single administration. In this study, the suitability of Poly (D, L)-lactide-co-glycolic acid (PLGA), Poly lactic acid (PLA) and Chitosan polymers as adjuvants for HBsAg were investigated.

Methods: We used solvent evaporation and emulsion cross-linking techniques to encapsulate HBsAg into the different polymeric systems.