An unusual etiology of testicular avulsion: A case report.

Introduction: Dog bites are a common presentation in emergency departments. However, scrotal injuries with complete testicular avulsion are exceedingly rare.

Case Presentation: We present a case of a dog bite to the scrotum with complete detachment of the testis and right hemiscrotum in an intoxicated 48-year-old man, who was treated with wound irrigation, debridement, antibiotic prophylaxis, tetanus and rabies vaccination, and a covering scrotoplasty.

Spatially Preserved Multi-Region Transcriptomic Subtyping and Biomarkers of Chemoimmunotherapy Outcome in Extensive-Stage Small Cell Lung Cancer.

Purpose: Transcriptomic subtyping holds promise for personalized therapy in extensive-stage small cell lung cancer (ES-SCLC). In this study, we aimed to assess intratumoral transcriptomic subtype diversity and to identify biomarkers of long-term chemoimmunotherapy benefit in human ES-SCLC.

Experimental Design: We analyzed tumor samples from 58 patients with ES-SCLC enrolled in two multicenter single-arm phase IIIb studies evaluating frontline chemoimmunotherapy in Spain: n = 32 from the IMfirst trial and n = 26 from the CANTABRICO trial.

Müllerian Cyst: An Uncommon Etiology of Chronic Pelvic Pain Syndrome in Men.

Chronic pelvic pain syndrome (CPPS) in men is a complex pathological entity with a delicate nosological diagnosis and multiple etiological hypotheses dominated by urological causes. The Müllerian cyst has an embryological origin and is part of an organic anomaly of the male urogenital tract, incidentally detected during an initial infertility examination or in the presence of non-specific urinary symptoms. By its mass effect, it puts tension on the pelvic floor muscles and induces a stimulation of nerves which could explain its implication in the CPPS.

Complex case of ureteropelvic junction obstruction with bifid renal pelvis in ectopic kidney: A rare combination.

Introduction: Renal pelvis bifidity, ectopic pelvic kidney, and ureteropelvic junction obstruction are rare urinary tract anomalies resulting from embryological developmental variations. Their coexistence in one kidney is exceedingly uncommon.

Case Presentation: An 18-year-old male with no prior medical history presented with right-sided lumbar pain.

Primary diffuse large B-Cell lymphoma of the female urethra: A case report.

Introduction: Primary diffuse large B-cell lymphoma (DLBCL) of the female urethra is a highly uncommon malignancy.

Case Report: A 78-year-old woman presents with urethrorrhagia and dysuria. Clinical examination revealed a protruding mass at the urethral meatus, accompanied by bilateral inguinal adenopathies.

Angiomatous Urethral Caruncle After Ureteroscopy: A Case Report.

Urethral caruncle is a rare condition. Although relatively common in postmenopausal women, its occurrence after a urological endoscopic procedure is unusual. Here, we report the case of a postmenopausal woman who presented with a symptomatic urethral caruncle two weeks after a ureteroscopy for a right ureteral calculus.

Brief report: High incidence of peridiagnosis thromboembolic events in patients with BRAF-mutant lung cancer.

Introduction: We aimed to determine if advanced BRAF-mutant NSCLC has a higher thromboembolic events (TEE) rate than the expected.

Methods: Between 2008 and 2021, 182 patients with BRAF-mutant advanced NSCLC (BRAF V600E, n = 70; BRAF non-V600E, n = 112) were retrospectively identified from 18 centers in Spain. Patients received chemotherapy (n = 147), immunotherapy (n = 69), targeted therapy (n = 42), and immunotherapy + chemotherapy (n = 26).

Priapism associated with penile haematoma following a scorpion sting in a child: A rare case report.

Priapism is a rare condition in paediatrics. Although its association with scorpion envenomation has been documented, cases involving an associated penile haematoma are extremely rare. To the best of our knowledge, we hereby present the first documented case of this unique association in a nine-year-old boy following a scorpion sting.

Spontaneous Iliopsoas Hematoma in a Patient on Acenocoumarol: Report of a Rare Case.

Spontaneous hematoma of the iliopsoas is a rare pathological circumstance; in the majority of cases published in the literature, it is associated with disorders of hemostasis due to anticoagulant treatment or coagulopathies. We present a case of a 64-year-old man on acenocoumarol, an anticoagulant of the vitamin K antagonist family, for atrial fibrillation, who presented with a severe left hip and flank pain with a huge ecchymosis on the left flank and a partial inability to extend the left thigh. A CT scan confirmed the diagnosis of iliopsoas hematoma.

Periurethral abscess in corpus spongiosum caused by urinary tract infection: A case report and review of literature.

Penile abscesses are rare and mainly interest the corpora cavernosa or soft tissue of the external genitalia, while involvement of the corpus spongiosum is unusual, with only a few cases published in the literature. We report the case of an abscess of the corpus spongiosum secondary to a documented urinary tract infection in a young immunocompetent patient with no particular pathological history. To our knowledge this is the first case reported in this context.

Emerging immune checkpoint inhibitors for the treatment of non-small cell lung cancer.

Introduction: Over the last decade, immune checkpoint inhibitors (ICIs) have impacted on the standard therapy for patients with non-small cell lung cancer (NSCLC). ICIs first showed efficacy in patients with advanced disease who had progressed after chemotherapy, later reaching the first-line therapy context alone, in combination with chemotherapy, and/or with dual-immunotherapy regimens.

Areas Covered: Most of their benefit is, however, restricted to just 20% of patients due to primary or emergence of acquired resistance.

Rudy and Borden technique for penile self-mutilation in Klingsor syndrome: a case report.

Penile self-mutilation is a challenging situation that often jeopardizes sexual and voiding functions. Surgical treatment is currently based on penile replantation, nevertheless its requirements of time, conservation, and quality of amputated phallus and microsurgical expertise are not constantly available. Here, we present a case of penile self-inflicted amputation in a 28-years-old patient suffering from a psychotic disorder, who did not preserve the amputated phallus.

Recent advances in neoadjuvant immunotherapy for urothelial bladder cancer: What to expect in the near future.

Urothelial bladder cancer (UC) is the most common malignancy involving the urinary system and represents a significant health problem. Immunotherapy has been used for decades for UC with intravesical bacillus Calmette-Guérin (BCG) set as the standard of care for non-muscle-invasive bladder cancer (NMIBC). The advent of immune checkpoint inhibitors (ICIs) has completely transformed the treatment landscape of bladder cancer enabling to expand the treatment strategies.

[The role of open nephrolithotomy in the treatment of coralliform stones: a series of 53 patients].

This study aims to discuss the role of open surgery in the treatment of renal lithiasis, including coralliform stones, with the advent of new less invasive techniques. We report a series of 53 cases of coralliform stones whose data were collected in our Hospital during a period of 7 years, from January 2011 to January 2018. The patients underwent open nephrolithotomy by lombotomy.

[Giant prostatic adenoma].

We here report the case of a 75 year old patient, with lower urinary tract obstructive syndrome such as dysuria, nocturnal pollakiuria and dribbling. Clinical examination showed good general condition by examining the rectum with the finger, soft, painless prostate increased in volume with obliteration of the median sulcus. PSA level was 2,1ng/ml, prostatic weight was 240 g on ultrasound.

[An unusual intraurethral foreign body: a case report].

In medical literature there are several case reports of foreign bodies introduced into the urethra. Foreign bodies are usually inserted as result of erotic activities, psychiatric disorders and, rarely, in an attempt to evacuate the urine. Diagnosis is based on clinical examination and imaging tests.

[Scrotal fistulas revealing mucinous adenocarcinoma of the scrotum: about a case].

Scrotales fistulas are rare and often represent secondary lesions of tuberculosis. Mucinous adenocarcinomas are tumors containing at least 50% of extracellular mucus. They occur most commonly in the rectosigmoid; scrotal location is rare.

[Neuroendocrine carcinoma of the bladder: about 5 cases].

Neuroendocrine carcinoma of the bladder is a rare histological entity, characterized by the ability to metastasize quickly and associated with a poor prognosis. The purpose of this study was to analyze the clinical, histological, therapeutic and prognostic characteristics of neuroendocrine carcinoma of the bladder. We conducted a retrospective study collecting data from the medical records of 5 patients in the Department of Urology, at the Ibn Sina University Hospital during the period between January 2008 and June 2015.

[Primitive benign retrovesical schwannoma: an extremely rare tumor, a case report].

Schwannoma is usually a benign tumor of nervous origin arising from Schwann sheath cells. It is an extremely rare tumour because of its low incidence and its retrovescical localization. Histological and immunohistochemical examinations confirm the histological type as well as the benign or malignant origin of schwannoma.

Distraction osteogenesis. A comparison of corticotomy techniques.

The left hindlimbs of 15 adult mongrel dogs were lengthened using the Ilizarov external fixator. Five dogs were assigned to each of three separate groups: (I) corticotomy; (II) osteotomy with multiple drill holes and an osteotome; (III) osteotomy with an oscillating saw. Distraction began on postoperative day seven and continued at a rate of 0.