Axillary metastases after port site recurrences of gallbladder carcinoma: a case report.

Background: Incidental gallbladder carcinoma is often discovered after elective laparoscopic cholecystectomy for cholecystitis or cholecystolithiasis. Port site recurrences may occur. Patients with port site metastases of gallbladder carcinoma have a poor prognosis.

Geometric Remodeling of the Perirenal Aortic Neck at and Adjacent to the Double Sealing Ring of the Anaconda Stent-Graft After Endovascular Aneurysm Repair.

To evaluate if the radial force of the double sealing ring of the Anaconda stent-graft induces dilatation in the perirenal aortic neck adjacent to the rings. This study evaluated the serial electrocardiogram-gated computed tomography scans of 15 abdominal aortic aneurysm patients (mean age 72.8±3.

Chromate Binding and Removal by the Molybdate-Binding Protein ModA.

Effective and cheap methods and techniques for the safe removal of hexavalent chromate from the environment are in increasingly high demand. High concentrations of hexavalent chromate have been shown to have numerous harmful effects on human biology. We show that the E.

Factors Associated with Short-Term Mortality After Surgical Oncologic Emergencies.

Background: The clinical outcome of patients with oncologic emergencies is often poor and mortality is high. It is important to determine which patients may benefit from invasive treatment, and for whom conservative treatment and/or palliative care would be appropriate. In this study, prognostic factors for clinical outcome are identified in order to facilitate the decision-making process for patients with surgical oncologic emergencies.

Current management of surgical oncologic emergencies.

Objectives: For some oncologic emergencies, surgical interventions are necessary for dissolution or temporary relieve. In the absence of guidelines, the most optimal method for decision making would be in a multidisciplinary cancer conference (MCC). In an acute setting, the opportunity for multidisciplinary discussion is often not available.

An adrenal mass and increased catecholamines: monoamine oxidase or pheochromocytoma effect?

Hormonal evaluation in patients with an adrenal incidentaloma can be difficult in patients with comorbidities or in patients using interfering drugs. We present a case of a 54-year-old man who was evaluated for an adrenal mass. The medical history reported treatment with a monoamine oxidase (MAO) inhibitor for recurrent psychoses.

Mortality in emergency surgical oncology.

Purpose: Cancer patients can experience problems related to their disease or treatment. This study evaluated reasons for presentation at the emergency room (ER) and outcome of surgical oncology patients.

Methods: A retrospective chart review for all surgical oncology patients who presented at the ER of the UMCG for surgical consultation between October 1, 2012, and March 31, 2013.

Surgical emergencies in oncology.

An oncologic emergency is defined as an acute, potentially life threatening condition in a cancer patient that has developed as a result of the malignant disease or its treatment. Many oncologic emergencies are signs of advanced, end-stage malignant disease. Oncologic emergencies can be divided into medical or surgical.

A protein engineered to bind uranyl selectively and with femtomolar affinity.

Uranyl (UO2(2+)), the predominant aerobic form of uranium, is present in the ocean at a concentration of ~3.2 parts per 10(9) (13.7 nM); however, the successful enrichment of uranyl from this vast resource has been limited by the high concentrations of metal ions of similar size and charge, which makes it difficult to design a binding motif that is selective for uranyl.

Tetrazole and triazole as bioisosteres of carboxylic acid: discovery of diketo tetrazoles and diketo triazoles as anti-HCV agents.

A series of diketo tetrazoles and diketo triazoles were designed and synthesized as bioisosteres of α,γ-diketo acid, the active site inhibitor of HCV (Hepatitis C virus) polymerase NS5B. Among the synthesized compounds, 4-(4-fluorobenzyloxy)phenyl diketo triazole (30) exhibited anti-HCV activity with an EC50 value of 3.9 μM and an SI value more than 128.

Engineering bacterial two-component system PmrA/PmrB to sense lanthanide ions.

The Salmonella PmrA/PmrB two-component system uses an iron(III)-binding motif on the cell surface to sense the environmental or host ferric level and regulate PmrA-controlled gene expression. We replaced the iron(III)-binding motif with a lanthanide-binding peptide sequence that is known to selectively recognize trivalent lanthanide ions. The newly engineered two-component system (PmrA/PmrB) can effectively sense lanthanide ion and regulate gene expression in E.

Preparation of N-alkyl 2-pyridones via a lithium iodide promoted O- to N-alkyl migration: scope and mechanism.

An efficient and inexpensive LiI-promoted O- to N-alkyl migration of 2-benzyloxy-, 2-allyloxy-, and 2-propargyloxypyridines and heterocycles is reported. The reaction produces the corresponding N-alkyl 2-pyridones and analogues under green, solvent-free conditions in good to excellent yields (30 examples, 20-97% yield). This method has been shown to be intermolecular and requires heat and lithium cation to occur.

Effect of tibial slope on the stability of the anterior cruciate ligament-deficient knee.

Purpose: We aimed to quantify the effect of changes in tibial slope on the magnitude of anterior tibial translation (ATT) in the anterior cruciate ligament (ACL)-deficient knee during the Lachman and mechanized pivot shift tests. We hypothesized that increased posterior tibial slope would increase the amount of ATT of an ACL-deficient knee, while leveling the slope of the tibial plateau would decrease the amount of ATT.

Methods: Lachman and mechanized pivot shift tests were performed on hip-to-toe cadaveric specimens, and ATT of the lateral and the medial compartments was measured using navigation (n = 11).

Influence of the valgus force during knee flexion in neutral rotation.

Purpose: The pivot shift test is generally accepted to be a clinically useful tool. In the current study, the authors aimed to determine the minimum amount of valgus force required to elicit a positive pivot shift test utilizing a mechanized pivot shifter device in ACL-deficient knees. The authors proposed that increasing the applied force from a minimum critical value would lead to greater magnitudes of femoro-tibial translation.

[Pneumomediastinum in a child].

Background: Pneumomediastinum is a rare, benign condition in which air leaks through the alveolar membrane and collects in the mediastinum. Typical clinical symptoms include chest pain and dyspnoea. In the absence of underlying pathology, conservative treatment is sufficient for remission.

Software for compartmental translation analysis and virtual three-dimensional visualization of the pivot shift phenomenon.

Anterior cruciate ligament (ACL) injury may cause knee instability and may result in damage to the menisci and the articular cartilage. The pivot shift test is commonly used to identify rotational instability of the knee following injury to the ACL. The magnitude of lateral compartment translation correlates well with the grade of the pivot shift.

Effects of tibial slope changes in the stability of fixed bearing medial unicompartmental arthroplasty in anterior cruciate ligament deficient knees.

Patients with anterior cruciate ligament (ACL) deficiency may have increased failure rates with UKA as a result of abnormal contact stresses and altered knee kinematics. Variations in the slope of the tibial component in UKA may alter tibiofemoral translation, and affect outcomes. This cadaveric study evaluated tibiofemoral translation during the Lachman and pivot shift tests after changing the slope of a fixed bearing unicondylar tibial component.

Anterior cruciate ligament reconstruction after unicompartmental knee arthroplasty.

Purpose: ACL deficiency may cause abnormal knee kinematics and is associated with a tenfold increase in surgical failures after unicompartmental knee arthroplasty, such as aseptic loosening of the tibial compartment and medial bearing instability. The current investigators hypothesized that in a knee with UKA, single-bundle ACL reconstruction would restore tibiofemoral translation to levels similar to those of the intact ACL.

Methods: Two fresh frozen pelvis-to-toes specimens (four paired knees) were used.

A mechanized and standardized pivot shifter: technical description and first evaluation.

Purpose: The pivot shift test (PST) is a complex, multiplanar maneuver used to assess rotatory instability of the knee. The grading is subjective due to the broad range of examination techniques and lack of tibiofemoral motion quantification. The goal of this study was to develop and evaluate a mechanized device for quantitative assessment of the PST.

Synthesis of substituted N-benzyl pyridones via an O- to N-alkyl migration.

A new LiI-promoted O- to N-alkyl migration has been developed for the conversion of O-alkylated 2-hydroxy pyridines, quinolines, and pyrimidines to the corresponding N-alkylated heterocycles in good to excellent yields (57-99%). This method serves as an efficient means for the preparation of N-benzyl pyridones, quinolones, and pyrimidones.

beta-Glucosidase in cellulosome of the anaerobic fungus Piromyces sp. strain E2 is a family 3 glycoside hydrolase.

The cellulosomes of anaerobic fungi convert crystalline cellulose solely into glucose, in contrast with bacterial cellulosomes which produce cellobiose. Previously, a beta-glucosidase was identified in the cellulosome of Piromyces sp. strain E2 by zymogram analysis, which represented approx.

Measuring shear-induced self-diffusion in a counterrotating geometry.

The novel correlation method to measure shear-induced self-diffusion in concentrated suspensions of noncolloidal hard spheres which we developed recently [J. Fluid Mech. 375, 297 (1998)] has been applied in a dedicated counterrotating geometry.