Combating chemoresistance: Current approaches & nanocarrier mediated targeted delivery.

Chemoresistance, a significant challenge in effective cancer treatment needs clear elucidation of the underlying molecular mechanism for the development of novel therapeutic strategies. Alterations in transporter pumps, oncogenes, tumour suppressor genes, mitochondrial function, DNA repair processes, autophagy, epithelial-mesenchymal transition (EMT), cancer stemness, epigenetic modifications, and exosome secretion lead to chemoresistance. Despite notable advancements in targeted cancer therapies employing both small molecules and macromolecules success rates remain suboptimal due to adverse effects like drug efflux, target mutation, increased mortality of normal cells, defective apoptosis, etc.

Skin Tape Stripping Reveals Distinct Biomarker Profiles in Chronic Hand Eczema of Patients With and Without Comorbid Atopic Dermatitis.

Introduction: Chronic hand eczema (CHE) is a highly prevalent inflammatory skin condition which is often resistant to conventional treatments. Molecular insights of CHE remain limited. Tape stripping combined with high-throughput RNA sequencing can now provide a better insight into CHE pathogenesis in a minimally invasive fashion.

FOXP3 Transcriptionally Activates Fatty Acid Scavenger Receptor CD36 in Tumour-Induced Treg Cells.

The host immune system is adapted in a variety of ways by tumour microenvironment and growing tumour interacts to promote immune escape. One of these adaptations is manipulating the metabolic processes of cells in the tumour microenvironment. The growing tumour aggressively utilise glucose, its primary energy source available in tumour site, and produce lactate by Warburg effect.

Spectroscopic approach to optimize the biogenic silver nanoparticles for photocatalytic removal of ternary dye mixture and ecotoxicological impact of treated wastewater.

The fabricating of extremely effective, economical, ecologically safe, and reusable nanoparticle (NP) catalysts for the removal of water pollution is urgently needed. This study, spectroscopically optimizes the process parameters for the biogenic synthesis of AgNP catalysts using Cledrdendrum infortunatum leaf extract. The optimization of several synthesis parameters was systematically studied using UV-Vis spectroscopy to identify the ideal conditions for AgNPs formation.

Antifouling Immunomodulatory Copolymer Architectures That Inhibit the Fibrosis of Implants.

Immune reactions to medical implants often lead to encapsulation by fibrotic tissue and impaired device function. This process is thought to initiate by protein adsorption, which enables immune cells to attach and mount an inflammatory response. Previously, several antifibrotic materials have been either designed to reduce protein adsorption or discovered via high-throughput screens (HTS) to favorably regulate inflammation.

Microwave catalytic treatment using magnetically separable CoFeO spinel catalyst for high-rate degradation of malachite green dye.

The release of toxic chemical dyes from the industrial effluent poses huge challenges for the environmental engineers to treat it. Azo dyes encompass the huge part of textile discharges which are difficult to degrade due to their complex chemical aromatic structures and due to the presence of strong bonds (-N=N-). Thus, the removal of a carcinogenic azo dye (i.

Effect of the COVID-19 pandemic on unmet healthcare needs after hospital discharge in acute respiratory failure survivors: A multicenter prospective cohort study.

Survivors of acute respiratory failure (ARF) have complex healthcare needs postdischarge, frequently resulting in unmet needs. This prospective multicenter study explores the association between COVID-19 status and unmet healthcare needs in survivors of ARF following hospital discharge. We analyzed patient characteristics and unmet healthcare needs by COVID-19 status using a multivariable regression model with propensity weights.

Handheld portable device for delivering capped silver nanoparticles for antimicrobial applications.

We describe a simple, cost-effective, green method for producing capped silver nanoparticles (Ag NPs) using a handheld portable mesh nebulizer. The precursor solution containing a 1:1 mixture of silver nitrate (AgNO) and ligand (glycerol or sodium alginate) was sprayed using the nebulizer. The Ag NPs were generated in the water microdroplets within a few milliseconds under ambient conditions without any external reducing agent or action of a radiation source.

Antibacterial and safe chitosan-graphene hydrogel films: a promising nanotherapeutic for wound infections.

Pathogenic bacterial growth at wound sites, particularly , poses a serious threat during trauma. Delayed treatment can lead to increased inflammation and severe tissue damage. In this study, a chitosan cross-linked polycationic peptide-conjugated graphene-silver (CGrAP) nanocomposite hydrogel film was developed as an antibacterial wound dressing to treat infections.

Advocating for Paid Maternity Leave and Workplace Lactation Policy Reform and Implementation: Lessons Learned From Indonesia, Nigeria, the Philippines and Vietnam.

Maternity protection policies are designed to preserve the health of working women and their infants, support optimal infant and young child nutrition through breastfeeding and prevent workplace discrimination against women. The aim of this study was to identify how advocates may be able to effectively advance maternal leave and workplace lactation policies, two key maternity protection policies, and does so through an exploration of advocacy efforts in Indonesia, Nigeria, the Philippines and Vietnam. A desk review of programme and policy documents and 20 key informant interviews with diverse stakeholders explored advocacy efforts in each of the four countries.

Meta-structure of amorphous-inspired 65.1Co28.2Cr5.3Mo lattices augmented by artificial intelligence.

Unlabelled: A hatching-distance-controlled lattice of 65.1Co28.2Cr5.

Lower Ticagrelor Dosing in the Dual Antiplatelet Regimen for Neurointerventional Procedures.

Background: Ticagrelor, a P2Y12 inhibitor, offers a rapid onset and consistent platelet inhibition, making it a viable alternative for dual antiplatelet therapy (DAPT). The optimal ticagrelor dose for neurointerventional procedures, however, remains unclear. We report our experience with ticagrelor 60 mg twice daily plus aspirin 81 mg daily compared with the standard aspirin and clopidogrel regimen for intracranial stenting.

Crystalloid Liberal or Vasopressors Early Resuscitation in Sepsis-Study of Treatment's Echocardiographic Mechanisms (CLOVERS-STEM).

Importance: Receipt of fluid and vasopressors, common treatments in septic shock, may affect cardiac function.

Objectives: We sought to determine whether a liberal or restrictive fluid resuscitation strategy was associated with changes in cardiac function.

Design: We prospectively studied a subset of patients enrolled in the Crystalloid Liberal or Vasopressors Early Resuscitation in Sepsis (CLOVERS) trial, performing echocardiography at baseline and at 24 hours after randomization.

Clinical Characteristics of Patients With COPD and Comorbid Depression and Anxiety: Data From a National Multicenter Cohort Study.

Background: Most studies on mental health among individuals with COPD utilize screening questionnaires, which detect psychiatric symptoms, but cannot be used to diagnose depression/anxiety disorders. We utilized the Mini International Neuropsychiatric Interview (MINI) to identify depression/anxiety disorders meeting DSM-V diagnostic criteria and described associated disease burden in people with COPD.

Methods: This is a cross-sectional, secondary analysis of a multi-center study designed to evaluate anxiety questionnaires in COPD patients.

A standardized carotid endarterectomy care pathway is associated with lower ICU admission rates and a significant reduction in hospital charges.

Background: This study investigated the outcomes before and after initiation of a postoperative care pathway for carotid endarterectomy (CEA) patients.

Methods: A CEA pathway was developed with stakeholders. We compared in-hospital outcomes and charges (USD) for patients undergoing CEA 18 months before (11/2019-04/2021) vs.

Understanding the formation of nitrate from nitrogen at the interface of gas-water microbubbles.

Water microbubbles containing Fe ions have been found to efficiently transform nitrogen (N) to nitrate (NO ) by initiating Fenton's reaction at the gas-water interface. Herein, we elucidate the mechanism of the formation of nitrate (NO ) from nitrogen (N) at the microbubble interface. Several experimental studies were conducted to identify the intermediates formed during the conversion.

Tailoring the mechanical properties of macro-porous PVA hydrogels for biomedical applications.

Polyvinyl alcohol (PVA) is a biocompatible biopolymer with superior dimensional and mechanical stability when compared to naturally available biomaterials such as collagen and gelatin. Furthermore, PVA in hydrogel form behaves non-linearly during mechanical loading, generating a response like soft biological tissues. Generally, PVA hydrogels are fabricated using freeze-thaw cycles (FTCs) and changing the number of FTCs gives control over its mechanical properties.

Biochemical Signal-Induced Supramolecular Hydrogelation for Structured Free-Standing Soft Material Formation.

Cells coordinate their activity and regulate biological processes in response to chemical signals. Mimicking natural processes, control over the formation of artificial supramolecular materials is of high interest for their application in biology and medicine. Supramolecular material that can form in response to chemical signals is important for the development of autonomously responsive materials.

Dual Emission and Low-Temperature Afterglow in Xanthone-Dibenzoazepine for High EQE Host-Guest OLEDs with Low-Efficiency Roll-Off.

Research has been driven to demonstrate organic light-emitting diodes (OLEDs) with high efficiency, and in the quest for new materials, thermally activated delayed fluorescence (TADF) emitters have been employed. Preparation of donor-acceptor (D-A) π-conjugates is a useful guideline for developing TADF emitters. TADF emitters have shown excellent progress and high maximum external quantum efficiency (EQE) for OLEDs in the recent past; however, they suffer with substantial roll-off resulting in a decrease in their efficiency.

Bone Healing via Carvacrol and Curcumin Nanoparticle on 3D Printed Scaffolds.

Carvacrol is a potent antimicrobial and anti-inflammatory agent, while curcumin possesses antioxidant, anti-inflammatory, and anticancer properties. These phytochemicals have poor solubility, bioavailability, and stability in their free form. Nanoencapsulation can reduce these limitations with enhanced translational capability.