Harnessing orbital Hall effect in spin-orbit torque MRAM.

Spin-Orbit Torque (SOT) Magnetic Random-Access Memory (MRAM) devices offer improved power efficiency, nonvolatility, and performance compared to static RAM, making them ideal, for instance, for cache memory applications. Efficient magnetization switching, long data retention, and high-density integration in SOT MRAM require ferromagnets (FM) with perpendicular magnetic anisotropy (PMA) combined with large torques enhanced by Orbital Hall Effect (OHE). We have engineered a PMA [Co/Ni] FM on selected OHE layers (Ru, Nb, Cr) and investigated the potential of theoretically predicted larger orbital Hall conductivity (OHC) to quantify the torque and switching current in OHE/[Co/Ni] stacks.

Build muscles and protect myelin.

Multiple sclerosis (MS) is a chronic and debilitating autoimmune disease of the central nervous system (CNS) in which a CNS-driven immune response destroys myelin, leading to wide range of symptoms including numbness and tingling, vision problems, mobility impairment, etc. Oligodendrocytes are the myelinating cells in the CNS, which are generated from oligodendroglial progenitor cells (OPCs) via differentiation. However, for multiple reasons, OPCs fail to differentiate to oligodendrocytes in MS and as a result, stimulating the differentiation of OPCs to oligodendrocytes is considered beneficial for MS.

Purple non sulfur bacteria for biotechnological applications.

In this review, we focus on how purple non sulfur bacteria (PNSB) can be leveraged for sustainable bioproduction to support the circular economy (CE). We discuss the state of the field with respect to the use of purple bacteria for energy production, their role in wastewater treatment, as a fertilizer, and as a chassis for bioplastic production. We explore their ability to serve as single cell protein and production platforms for fine chemicals from waste materials.

Global challenges and solutions to achieving and sustaining measles and rubella elimination.

Measles and rubella have long been recognized as priorities for disease prevention because of their devastating consequences for child health; hence, all World Health Organization (WHO) regions currently have a goal to eliminate measles and four out of six WHO regions have a goal to eliminate rubella. Significant global progress has been made in the twenty-first century, with more than 40% of countries in the world verified by a Regional Verification Commission as having eliminated measles and more than 50% of countries having sustained rubella elimination. Making further progress will require addressing fundamental gaps in health systems, a particular challenge in the current global context where many countries face multiple barriers to both sustaining and achieving measles and rubella elimination.

Oleylammonium fluoride passivated blue-emitting 2D CsPbBr nanoplates with near-unity photoluminescence quantum yield: safeguarding against threats from external perturbations.

Quantum-confined, two-dimensional (2D) CsPbBr (CPB) nanoplates (NPLs) have emerged as exceptional candidates for next-generation blue LEDs and display technology applications. However, their large surface-to-volume ratio and detrimental bromide vacancies adversely affect their photoluminescence quantum yield (PLQY). Additionally, external perturbations such as heat, light exposure, moisture, oxygen, and solvent polarity accelerate their transformation into three-dimensional (3D), green-emitting CPB nanocrystals (NCs), thereby resulting in the loss of their quantum confinement.

Corrigendum: The immunomodulatory impact of naturally derived neem leaf glycoprotein on the initiation progression model of 4NQO induced murine oral carcinogenesis: a preclinical study.

[This corrects the article DOI: 10.3389/fimmu.2024.

Giant Infected Pseudoaneurysms of Left Anterior Descending Artery After Percutaneous Intervention: A Fatal Complication.

Infected coronary aneurysms are rare in clinical practice and represent a catastrophic complication following percutaneous coronary interventions. A high index of suspicion is imperative in patients presenting with fever a few weeks after percutaneous coronary intervention. Early diagnosis and surgical repair are key to mitigating the morbidity and mortality associated with it.

Does Physiological Intracytoplasmic Sperm Injection Improve Outcome in Men with Abnormal Semen Parameters: A Retrospective Cohort Study.

Background: As the male factor in infertility is on rising trend, we need a promising tool for sperm selection to improve the embryo development.

Aim: The present study compares the embryological and clinical parameters between physiological intracytoplasmic sperm injection (PICSI) and conventional intracytoplasmic sperm injection (ICSI) in abnormal semen parameters.

Settings And Design: This was a retrospective cohort study.

Progress Toward Measles Elimination - Worldwide, 2000-2023.

Measles vaccination effectively prevents measles, a highly contagious disease that can cause severe complications and death and requires high population immunity to interrupt transmission. This report describes measles elimination progress during 2000-2023. During 2000-2023, an estimated 60.

Dynamical mechanisms of how an RNN keeps a beat, uncovered with a low-dimensional reduced model.

Despite music's omnipresence, the specific neural mechanisms responsible for perceiving and anticipating temporal patterns in music are unknown. To study potential mechanisms for keeping time in rhythmic contexts, we train a biologically constrained RNN, with excitatory (E) and inhibitory (I) units, on seven different stimulus tempos (2-8 Hz) on a synchronization and continuation task, a standard experimental paradigm. Our trained RNN generates a network oscillator that uses an input current (context parameter) to control oscillation frequency and replicates key features of neural dynamics observed in neural recordings of monkeys performing the same task.

Nanostructured Lipid Carrier-based Topical Gels as Novel Drug Delivery System: A Comprehensive Overview.

Nanostructured lipid carriers (NLCs) are lipidic nanocarriers that recover the permanency and capacity of drug payloads. NLCs are well-known as second-generation lipid nanocarriers with an unstructured matrix, presenting potentially advantageous nanocarrier systems with marketable opportunities because of reproducible production methodologies and biocompatible lipidic excipients. These (NLCs) are now recognized as a very promising nanocarrier structure for the efficient delivery of drugs via different administration routes.

Reliability and Validity of Hindi Version of the Confusion Assessment Method for Intensive Care Unit (CAM-ICU) for Diagnosis of Delirium: A Cohort Study.

Background: The confusion assessment method for the intensive care unit (CAM-ICU) is a bedside tool to diagnose delirium in critically ill patients. This study aims to determine the reliability and validity of the Hindi version of CAM-ICU against the Diagnostic and Statistical Manual (DSM), fourth edition text revision (DSM-IV-TR), and DSM, fifth edition (DSM-5) criteria for diagnosis of delirium.

Methods: Seventy-five Hindi-speaking consenting patients ≥18-year-old with Richmond Agitation Sedation Scale ≥-3 and an anticipated ICU stay > 48 hours were included.

Impact of Loss Mechanisms on Linear Spectra of Excitonic and Polaritonic Aggregates.

The presence of loss mechanisms governed by empirical timescales can profoundly affect the dynamics in molecular systems, leading to changes in their spectra. However, incorporation of these effects along with the system's interaction with the thermal dissipative environments proves to be challenging. In this work, we demonstrate the possibility of utilizing the recently developed path integral Lindblad dynamics (PILD) method to study the linear spectra of molecular aggregates.

How can quantum computing be applied in clinical trial design and optimization?

Clinical trials are necessary for assessing the safety and efficacy of treatments. However, trial timelines are severely delayed with minimal success due to a multitude of factors, including imperfect trial site selection, cohort recruitment challenges, lack of efficacy, absence of reliable biomarkers, etc. Each of these factors possesses a unique computational challenge, such as data management, trial simulations, statistical analyses, and trial optimization.

Mentha spicata Mediated Formulation of Iron Oxide Nanoparticles Exhibit Superior Antimicrobial, Antioxidant, and Photodegradation Propensity Compared to Chemically Formulated Counterparts.

Introduction: Iron oxide nanoparticles demonstrate tremendous potential in preserving the ecological balance of the environment since they act as antimicrobial agents and efficient photocatalysts. However, environmental sustainability has challenged the synthesis protocols of nanomaterials.

Method: This study compares the green synthesis method with the scalable chemical synthesis method.

Recent Advances in the Preparation, Properties, and Applications of Solid Lipid Nanoparticles in Drug Delivery.

Solid lipid nanoparticles (SLNs) are one of the extensively utilized nanocarriers in the pharmaceutical field due to their biocompatibility and biodegradability. These features of the carrier system have fuelled its use as the drug delivery system since the last three decades. This review presents different SLN preparation techniques, such as high shear homogenization, hot homogenization, cold homogenization, microemulsion-based technique, etc.

Behavioural and transgenerational effects of artificial light at night (ALAN) of varying spectral compositions in zebrafish (Danio rerio).

Artificial light at night (ALAN) can disrupt the natural behaviour, physiology, and circadian rhythms of organisms exposed to it, and therefore presents a significant and widespread ecological concern. ALAN typically comprises a wide range of wavelengths, and different wavelengths have different effects on circadian clocks. In the animals investigated thus far, short and middle wavelengths are intensely involved in synchronisation and entrainment, but we still have a poor understanding of how different wavelengths might affect behaviour when animals are exposed to ALAN, in particular whether some wavelengths are disproportionally detrimental.

Influence of buffer on colloidal stability, microstructure, and rheology of cellulose nanocrystals in hyaluronic acid suspensions.

Hyaluronic acid (HA) is a natural biopolymer found in various human tissues, while cellulose nanocrystals (CNCs) extracted from pulp fibers have unique rheological properties and biocompatibility. Due to the superior biomechanical properties of CNC and HA, a CNC-based HA suspension may be useful in biomedical applications. While buffers are an essential constituent of any suspension used for biomedical applications to maintain the desired pH level, they can significantly affect the properties of the suspension, including colloidal stability, microstructure, and rheological characteristics.

National Survey of Otolaryngology Program Directors Regarding Recruitment Methods for Underrepresented in Medicine Residents.

Objective: To characterize Otolaryngology residency program strategies for recruiting underrepresented minorities in medicine (URiM) residents and their perceived effectiveness, and explore perceived barriers to recruitment.

Design: We conducted a survey of Otolaryngology program directors (PDs) at the 122 accredited programs within the United States, utilizing a validated and previously published survey utilized within the OB-GYN literature. We solicited information regarding recruitment of underrepresented minorities in medicine (URiM) applicants, effectiveness of strategies, and perceived barriers in recruitment.

Pressure-induced magnetic and topological transitions in non-centrosymmetric MnInTe.

In recent years, the study of magnetic topological materials, with their variety of exotic physics, has significantly flourished. In this work, we predict the interplay of magnetism and topology in the non-centrosymmetric ternary manganese compound MnInTeunder external hydrostatic pressure, using first-principles calculations and symmetry analyses. At ambient pressure, the ground state of the system is an antiferromagnetic insulator.

Matrix sketching framework for linear mixed models in association studies.

Linear mixed models (LMMs) have been widely used in genome-wide association studies to control for population stratification and cryptic relatedness. However, estimating LMM parameters is computationally expensive, necessitating large-scale matrix operations to build the genetic relationship matrix (GRM). Over the past 25 years, Randomized Linear Algebra has provided alternative approaches to such matrix operations by leveraging , which often results in provably accurate fast and efficient approximations.