Publications by authors named "Bosch-Amate X"
Rheumatologic complications of CAR-T Cell therapy. Experience of a single center.
Semin Arthritis Rheum
December 2024
Introduction: Chimeric Antigen Receptor T-cell (CAR-T) therapy has emerged as a promising treatment for hematological malignancies. However, its association with immune-related complications such as rheumatic complications, is not well defined.
Methods: We conducted a retrospective study to analyze rheumatic complications in 310 patients treated with CAR-T therapy at a single center from January 2020 to May 2024.
Article Synopsis
- - A study evaluated the effectiveness and safety of dupilumab for treating bullous pemphigoid in elderly patients, with a focus on those who typically have other health issues that make standard treatments unsuitable.
- - The results showed that 53.4% of patients achieved complete remission within 4 weeks and 95.7% by week 52, with a significant reduction in itchiness and a dramatic decrease in the need for corticosteroids.
- - The treatment was found to be safe, with most adverse events being mild, and factors like shorter disease duration and exclusive skin involvement were linked to better treatment responses.
This retrospective cohort study assessed the efficacy and safety of Janus kinase (JAK) inhibitors, tofacitinib and baricitinib, in 14 patients with refractory dermatomyositis (DM), a multisystemic autoimmune disorder with limited therapeutic options. Results demonstrated a significant median decrease of 21 points and a 76% reduction in the Cutaneous Dermatomyositis Disease Area and Severity Index (CDASI) scores, along with a complete resolution of muscular symptoms in 64% of the patients. JAK inhibitors were effective in managing refractory DM across various subtypes with mild and manageable adverse events.
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- Bullous pemphigoid (BP) is a common autoimmune blistering condition usually affecting older adults with various health issues, traditionally treated with corticosteroids, which have numerous side-effects.* -
- A study assessed the use of omalizumab, an IgE-targeting monoclonal antibody, for treating BP in patients who had previously used other therapies, finding that 83% of patients responded to the treatment.* -
- The results showed that omalizumab was well-tolerated with no reported side-effects, highlighting its potential as a safer and effective alternative for BP treatment compared to conventional therapies.*
Article Synopsis
- Sweet syndrome is a skin condition linked to various medical issues, with a study in Spain analyzing 93 patients from 2001 to 2021 to uncover its characteristics and associations with malignancy and other disorders.* -
- The majority of cases were either idiopathic, associated with malignancies like acute myeloid leukaemia, or reactive to infections, with specific symptoms and histological types identified, showing that pain and nodules relate to subcutaneous-Sweet syndrome.* -
- Key findings indicate that male sex, fever, and other clinical factors are linked to malignancy in Sweet syndrome patients, suggesting that careful monitoring and a 6-month follow-up are important for those experiencing relapses, especially with myelodys
Article Synopsis
- Localized bullous pemphigoid (LBP) is a rare skin condition affecting specific body areas, often triggered by local factors in patients with pre-existing antibodies against the basement membrane.
- A study of 7 patients showed various local triggers such as surgery and burns, and introduced diagnostic criteria based on the findings and existing guidelines.
- Follow-up revealed that 3 patients progressed to generalized bullous pemphigoid, with many LBP cases linked to prior injuries, particularly affecting older women and frequently involving the lower limbs.
High-risk mucosal human papillomavirus-associated squamous cell carcinoma of the fingers presents distinctive clinicopathological characteristics and outcomes: a bicentric retrospective study.
Clin Exp Dermatol
March 2023
Article Synopsis
- High-risk mucosal human papillomavirus (HR-HPV) is potentially linked to cutaneous squamous cell carcinoma (cSCC) in finger tumours, with previous suggestions of genitodigital transmission needing further investigation.* -
- An observational study found HR-HPV in 33% of the cSCC cases on fingers, typically in younger patients, with tumours being smaller and more intraepidermal compared to non-HR-HPV cases.* -
- The study suggests that characteristics like basaloid morphology and absence of elastosis and inflammation can help identify HR-HPV tumours, highlighting the potential role of HR-HPV in the development of nonungual c
Nail involvement in psoriasis is common. It is seen in up to 80% of patients with psoriatic lesions and may be the only manifestation in 6% of cases. Nail psoriasis is correlated with more severe disease, characterized by earlier onset and a higher risk of psoriatic arthritis.
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- * Out of 93 cases analyzed, 41% had only anti-Dsc antibodies, with only 18% showing typical symptoms of pemphigus vulgaris or foliaceous, and about half showed mucosal involvement.
- * The findings highlight the need for increased awareness and suspicion of anti-Dsc antibodies in patients with atypical pemphigus symptoms, particularly those with pustules or specific histological features.
Background: Monitoring of disease activity in sclerosing dermatoses (SD) can be challenging and tools to support clinical decision-making are lacking.
Aim: To analyse the impact of high-frequency ultrasonography (HFUS) on the clinical management of SD and to describe the US characteristics of disease activity.
Methods: This was a cohort study of patients with various SD [morphoea, systemic sclerosis (SS) and chronic graft-versus-host disease (cGvHD)] who underwent HFUS between January 2017 and August 2019.