Publications by authors named "Bos-Kuijpers M"
Article Synopsis
- The study assessed how a tiered morphological approach can detect developmental neurotoxicity in rat offspring treated with methylazoxymethanol (MAM) during pregnancy.
- The approach involved measuring various morphometric parameters and showed significant effects at different levels, from overall brain size to specific neuron loss in the hippocampus, while cerebellar neurons remained unaffected.
- The results demonstrated that as researchers progressed through the tiers (from basic size measurements to detailed neuron evaluation), they could better identify the extent and specific locations of brain damage.
Our aim was to investigate a model of the morphologic approach proposed in guidelines for developmental neurotoxicity testing (DNT). Hereto, a limited DNT study [EPA Health Effects Test Guidelines OPPTS 870.6300, 1996a.
View Article and Find Full Text PDFThe term autoimmunity refers to physiologically normal immune processes against self-antigens. In rare cases, the regulatory mechanisms become deflective and the uncontrolled production of autoantibodies or activation of autoreactive T-cells can subsequently cause disease. Substances may be capable of evoking autoimmune disease, and it is a challenge in routine toxicology to recognize such substances.
View Article and Find Full Text PDFChronic toxicity and carcinogenicity study of erythritol in rats.
Regul Toxicol Pharmacol
October 1996
The potential toxicity and carcinogenicity of erythritol, a low-calorie sugar substitute, were examined in Wistar Crl:(WI) WU BR rats. Groups of 50 rats of each sex consumed diets with 0, 2, 5, or 10% erythritol, or 10% mannitol, for a period of 104-107 weeks. To each of these main groups, two satellite groups of 20 males each were attached for interim kills after 52 and 78 weeks of treatment.
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