Slipknotted and unknotted monovalent cation-proton antiporters evolved from a common ancestor.

While the slipknot topology in proteins has been known for over a decade, its evolutionary origin is still a mystery. We have identified a previously overlooked slipknot motif in a family of two-domain membrane transporters. Moreover, we found that these proteins are homologous to several families of unknotted membrane proteins.

Genus for biomolecules.

The 'Genus for biomolecules' database (http://genus.fuw.edu.