microbeMASST: a taxonomically informed mass spectrometry search tool for microbial metabolomics data.

microbeMASST, a taxonomically informed mass spectrometry (MS) search tool, tackles limited microbial metabolite annotation in untargeted metabolomics experiments. Leveraging a curated database of >60,000 microbial monocultures, users can search known and unknown MS/MS spectra and link them to their respective microbial producers via MS/MS fragmentation patterns. Identification of microbe-derived metabolites and relative producers without a priori knowledge will vastly enhance the understanding of microorganisms' role in ecology and human health.

A Taxonomically-informed Mass Spectrometry Search Tool for Microbial Metabolomics Data.

MicrobeMASST, a taxonomically-informed mass spectrometry (MS) search tool, tackles limited microbial metabolite annotation in untargeted metabolomics experiments. Leveraging a curated database of >60,000 microbial monocultures, users can search known and unknown MS/MS spectra and link them to their respective microbial producers via MS/MS fragmentation patterns. Identification of microbial-derived metabolites and relative producers, without knowledge, will vastly enhance the understanding of microorganisms' role in ecology and human health.

Identifying the provenance and quantifying the contribution of dust sources in EPICA Dronning Maud Land ice core (Antarctica) over the last deglaciation (7-27 kyr BP): A high-resolution, quantitative record from a new Rare Earth Element mixing model.

Antarctic ice cores have revealed the interplay between dust and climate in the Southern Hemisphere. Yet, so far, no continuous record of dust provenance has been established through the last deglaciation. Here, using a new database of 207 Rare Earth Element (REE) patterns measured in dust and sediments/soils from well-known potential source areas (PSA) of the Southern Hemisphere, we developed a statistical model combining those inputs to provide the best fit to the REE patterns measured in EPICA Dronning Maud Land (EDML) ice core (E.

Pleistocene drivers of Northwest African hydroclimate and vegetation.

Savanna ecosystems were the landscapes for human evolution and are vital to modern Sub-Saharan African food security, yet the fundamental drivers of climate and ecology in these ecosystems remain unclear. Here we generate plant-wax isotope and dust flux records to explore the mechanistic drivers of the Northwest African monsoon, and to assess ecosystem responses to changes in monsoon rainfall and atmospheric pCO. We show that monsoon rainfall is controlled by low-latitude insolation gradients and that while increases in precipitation are associated with expansion of grasslands into desert landscapes, changes in pCO predominantly drive the C/C composition of savanna ecosystems.

Bioactivity of Spongian Diterpenoid Scaffolds from the Antarctic Sponge .

The Antarctic sponge is rich in defensive terpenoids with promising antimicrobial potential. Investigation of this demosponge has resulted in the generation of a small chemical library containing diterpenoid secondary metabolites with bioactivity in an infectious disease screening campaign focused on , , and methicillin-resistant (MRSA) biofilm. In total, eleven natural products were isolated, including three new compounds designated dendrillins B-D (-).

Monsoon-driven Saharan dust variability over the past 240,000 years.

Reconstructions of past Saharan dust deposition in marine sediments provide foundational records of North African climate over time scales of 10 to 10 years. Previous dust records show primarily glacial-interglacial variability in the Pleistocene, in contrast to other monsoon records showing strong precessional variability. Here, we present the first Saharan dust record spanning multiple glacial cycles obtained using Th normalization, an improved method of calculating fluxes.

WRINKLED1 and ACYL-COA:DIACYLGLYCEROL ACYLTRANSFERASE1 regulate tocochromanol metabolism in Arabidopsis.

Photosynthetic organisms such as plants, algae and some cyanobacteria synthesize tocochromanols, a group of compounds that encompasses tocopherols and tocotrienols and that exhibits vitamin E activity in animals. While most vitamin E biosynthetic genes have been identified in plant genomes, regulatory genes controlling tocopherol accumulation are currently unknown. We isolated by forward genetics Arabidopsis enhanced vitamin E (eve) mutants that overaccumulate the classic tocopherols and plastochromanol-8, and a tocochromanol unknown in this species.

African humid periods triggered the reactivation of a large river system in Western Sahara.

The Sahara experienced several humid episodes during the late Quaternary, associated with the development of vast fluvial networks and enhanced freshwater delivery to the surrounding ocean margins. In particular, marine sediment records off Western Sahara indicate deposition of river-borne material at those times, implying sustained fluvial discharges along the West African margin. Today, however, no major river exists in this area; therefore, the origin of these sediments remains unclear.

Delirium in patients with cancer: what nurses need to know to improve care.

Background: Delirium is a serious problem when caring for a patient with cancer in the hospital. Delirium causes major risks and concerns for patients, family members, and healthcare workers, and it often goes unrecognized and has many clinical manifestations.

Objectives: This article aims to evaluate whether a nursing educational program on the topic of delirium would increase the nursing staff's knowledge and confidence in managing patients with delirium.

A Chinese imprint in insoluble pollutants recently deposited in central Greenland as indicated by lead isotopes.

A unique ∼ 10 year record of the lead isotopic composition of airborne insoluble particulate matter deposited in central Greenland was extracted from recent snow layers at NorthGRIP (75.1°N, 042.3°W; elevation 2,959 m), spanning the years 1989-2001.

[Pelvic and abdominal actinomycosis presenting as a parietal mass].

Introduction: Actinomycosis is a rare disease. It has a highly varied clinical picture and may simulate genital or gastrointestinal neoplasms.

Case: This 45-year-old woman was referred for suspected ovarian cancer, with secondary lesions of the liver and pelvic wall.

Reproducibility of transvaginal three-dimensional endometrial volume measurements with virtual organ computer-aided analysis (VOCAL) during ovarian stimulation.

Objective: To calculate inter- and intraobserver reliabilities for three-dimensional endometrial volume measurements during in vitro fertilization using virtual organ computer-aided analysis (VOCAL).

Patients And Methods: Three-dimensional ultrasound measurements of the endometrium using VOCAL software were performed on the day of oocyte retrieval in each of 79 consecutive patients undergoing in vitro fertilization or intracytoplasmic sperm injection. Endometrial volume was calculated every 15 degrees and every 30 degrees by two different observers in order to determine the reproducibility of the technique.