Publications by authors named "Borras R"

Background: Repetitive and restrictive behaviors (RRB) include simple motor stereotypes, tics and complex ritualized and rigid behaviors that are core symptoms in neurodevelopmental disorders such as obsessive-compulsive disorder (OCD), Tourette syndrome (TS) or autism spectrum disorder (ASD). Sensory phenomena (SP) are uncomfortable feelings, including bodily sensations, sense of inner tension, "just-right" perceptions, feelings of incompleteness, or "urge-only" phenomena, which have been described to precede, trigger, or accompany RRB. In such clinical contexts RRB and SP may be considered common variables that affect multiple aspects of daily functioning and are treatment targets.

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Introduction: Alcohol-related problems increase the probability of frequent emergency department (ED) use. In this study, we compared the direct healthcare expenses incurred during a single visit among frequent and non-frequent ED users and analyzed the impact of alcohol-related issues in healthcare costs arising from ED usage.

Methods: The study relied on secondary analyses of economic data from a 1:1 matched case-control study with the primary aim of identifying the clinical characteristics of hospital ED frequent users in a Mediterranean European environment with a public, universal, and tax-funded health system.

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Background And Aims: An unanticipated difficult airway is one of the greatest challenges for anesthesiologists. Proper preoperative airway assessment is crucial to reducing complications. However, current screening tests based on anthropometric features are of uncertain benefit.

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Article Synopsis
  • - The study aimed to find out if mood episodes (depression and mania) in young people with Bipolar Spectrum Disorder vary by latitude and seasons.
  • - Researchers evaluated mood in 413 participants over nearly 92 months, finding that depressive episodes were more frequent in winter, while manic episodes were more common in summer.
  • - The findings suggest the need for strategies to manage the seasonal impacts on mood for individuals with Bipolar Disorder, especially recognizing the differences across various locations.
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Objective: This study aimed to identify biochemical, hematological, and endocrinological abnormalities in a sample of children and adolescents with underweight AN and atypical AN and to compare these results between the two groups.

Method: Based on the 5th BMI-percentile admission, adolescents with underweight AN (n = 520) and atypical AN (n = 255) were included and medical records were reviewed.

Results: Low prealbumin (35%) and neutropenia (39%), and several abnormalities in endocrinological parameters (50%) were the most common alterations found in the whole sample.

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Introduction: We investigated whether structured maternal lifestyle interventions based on Mediterranean diet or stress reduction influence fetal-infant neurodevelopment detected by detailed fetal neurosonography and Ages and Stages Questionnaires 3rd edition (ASQ) at 12 months old.

Methods: This was a secondary analysis of a randomized clinical trial (2017-2020), including 1,221 singleton pregnancies at high risk for small-for-gestational age. Participants were randomized into three groups at 19-23 weeks' gestation: Mediterranean diet intervention, stress reduction program, or usual care.

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Background: Lifestyle factors are being increasingly studied in bipolar disorder (BD) due to their possible effects on both course of disease and physical health. The aim of this study was to jointly describe and explore the interrelations between diet patterns, exercise, pharmacological treatment with course of disease and metabolic profile in BD.

Methods: The sample consisted of 66 euthymic or mild depressive individuals with BD.

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  • Left bundle branch pacing (LBBP) is a potential alternative to cardiac resynchronization therapy (CRT) but is not suitable for all heart failure patients.
  • A study analyzed 187 CRT candidates, finding a success rate of 81.2% for LBBP implantation, with failed cases primarily due to poor QRS morphology and technical issues.
  • Key predictors for unsuccessful implantation included left ventricular end-diastolic diameter (LVEDD) and non-left bundle branch block (non-LBBB) morphology, with non-LBBB significantly increasing the risk of failure.
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Background: Affective states influence the sympathetic nervous system, inducing variations in electrodermal activity (EDA), however, EDA association with bipolar disorder (BD) remains uncertain in real-world settings due to confounders like physical activity and temperature. We analysed EDA separately during sleep and wakefulness due to varying confounders and potential differences in mood state discrimination capacities.

Methods: We monitored EDA from 102 participants with BD including 35 manic, 29 depressive, 38 euthymic patients, and 38 healthy controls (HC), for 48 h.

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Background: A partial delineation of targets for ablation of ventricular tachycardia (VT) during a stable rhythm is likely responsible for a suboptimal success rate. The abnormal low-voltage near-field functional components may be hidden within the high-amplitude far-field signal.

Objectives: The aim of this study was to evaluate the benefit and feasibility of functional substrate mapping using a full-ventricle S3 protocol and to assess its colocalization with arrhythmogenic conducting channels (CCs) on late gadolinium enhancement cardiac magnetic resonance.

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Aims: Longitudinal dyssynchrony correction and 'strain' improvement by comparable cardiac resynchronization therapy (CRT) techniques is unreported. Our purpose was to compare echocardiographic dyssynchrony correction and 'strain' improvement by conduction system pacing (CSP) vs. biventricular pacing (BiVP) as a marker of contractility improvement during 1-year follow-up.

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Background: Voltage mapping could identify the conducting channels potentially responsible for ventricular tachycardia (VT). Standard thresholds (0.5-1.

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Background: Atrial arrhythmogenic substrate is a key determinant of atrial fibrillation (AF) recurrence after pulmonary vein isolation (PVI), and reduced conduction velocities have been linked to adverse outcome. However, a noninvasive method to assess such electrophysiologic substrate is not available to date.

Objective: This study aimed to noninvasively assess regional conduction velocities and their association with arrhythmia-free survival after PVI.

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Background: Aerobic capacity has shown to predict physical and mental health-related quality of life in bipolar disorder (BD). However, the correlation between exercise respiratory capacity and mitochondrial function remains understudied. We aimed to assess longitudinally intra-individual differences in these factors during mood episodes and remission in BD.

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Background: Short-term cognitive impairment is associated with SARS-CoV-2 infection but the long-term impact is yet to be examined in detail. We aim to study the evolution of these symptoms in severe COVID-19 patients admitted to the intensive care unit (ICU) between April and December 2020 1 year after hospital discharge and to analyze its clinical correlates.

Method: A total of 58 patients agreed to participate in the 6 months follow-up and 30 at 1 year after hospital discharge.

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Objective: This study aimed to assess the relationship between childhood maltreatment (CM), objective and subjective cognition, and psychosocial functioning in adults with first-episode psychosis (FEP) by examining the moderating role of cognitive reserve (CR). A secondary objective was to explore whether unique CM subtypes (physical and/or emotional abuse, sexual abuse, physical and/or emotional neglect) were driving this relationship.

Method: Sixty-six individuals with FEP ( = 27.

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Background: Anti-leucine-rich glioma-inactivated protein 1 (LGI1) encephalitis is an autoimmune disorder that can be treated with immunotherapy, but the symptoms that remain after treatment have not been well described. We aimed to characterise the clinical features of patients with anti-LGI1 encephalitis for 1 year starting within the first year after initial immunotherapy.

Methods: For this prospective cohort study, we recruited patients with anti-LGI1 encephalitis as soon as possible after they had received conventional immunotherapy for initial symptoms; patients were recruited from 21 hospitals in Spain.

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Aims: Non-invasive myocardial scar characterization with cardiac magnetic resonance (CMR) has been shown to accurately identify conduction channels and can be an important aid for ventricular tachycardia (VT) ablation. A new mapping method based on targeting deceleration zones (DZs) has become one of the most commonly used strategies for VT ablation procedures. The aim of the study was to analyse the capability of CMR to identify DZs and to find predictors of arrhythmogenicity in CMR channels.

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: Left atrial (LA) remodelling and dilatation predicts atrial fibrillation (AF) recurrences after catheter ablation. However, whether right atrial (RA) remodelling and dilatation predicts AF recurrences after ablation has not been fully evaluated. : This is an observational study of 85 consecutive patients (aged 57 ± 9 years; 70 [82%] men) who underwent cardiac magnetic resonance before first catheter ablation for AF (40 [47.

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Article Synopsis
  • In June 2021, the WHO released a comprehensive catalogue of mutations in Mycobacterium tuberculosis that are linked to drug resistance, prompting researchers to evaluate its effectiveness for diagnosing drug-resistant tuberculosis in the relatively low prevalence area of Valencia, Spain.
  • A retrospective genomic study analyzed 785 tuberculosis isolates collected between 2014-2016, utilizing whole-genome sequencing (WGS) to predict resistance profiles based on the catalogue and comparing these predictions with actual phenotypic results.
  • The study found that while sensitivity for predicting resistance varied, with the highest at 85.4% for isoniazid, overall pan-susceptibility accuracy was 96.4%, highlighting some discrepancies in certain isolates that carried mutations known to cause borderline
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  • - The study investigates mitochondrial function in patients with bipolar disorder (BD) during mood episodes and after clinical remission, focusing on the differences in mitochondrial respiration between these states and healthy controls.
  • - Researchers observed a significant increase in mitochondrial oxygen consumption capacity (specifically electron transport chain activity) in BD patients during remission compared to acute episodes, suggesting improvements in mitochondrial bioenergetics.
  • - The study involved 20 BD patients (15 manic and 5 depressive) and 10 healthy controls, highlighting that while the results showed trends of improvement in both mood episodes, the differences were more pronounced in clinical remission.
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Background: Pulsed radiofrequency (PRF) treatment on the dorsal root ganglion (DRG) has been proposed as a good option for the treatment of persistent radicular pain based on its effect of neuromodulation on neuropathic pain. Autologous conditioned serum (ACS) therapy is a conservative treatment based on the patient's own blood. The aim of this manuscript is to develop a study protocol using ACS on the DRG as a target for its molecular modulation.

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