Expression level of CD117 (KIT) on ovarian cancer extracellular vesicles correlates with tumor aggressiveness.

Ovarian cancer is known to be the most lethal malignancy among all gynecological cancers affecting a large number of women worldwide. The treatment of ovarian cancer is challenging due to the high recurrence rate of the disease and is further complicated by acquired chemoresistance. Most ovarian cancer deaths are the result of the metastatic spread of drug-resistant cells.

[Paraoxonase: The Universal Factor of Antioxidant Defense in Human Body].

The paraoxonase (PON) gene family includes three members: PON1, PON2, and PON3 aligned in tandem on chromosome 7 in humans. All PON proteins share considerable structural homology and have the capacity to protect cells from oxidative stress; therefore, they have been implicated in the pathogenesis of several inflammatory diseases, particularly atherosclerosis. Increased production of reactive oxygen species as a result of decreased activities of mitochondrial electron transport chain complexes plays a role in the development of many inflammatory diseases, including atherosclerosis.

[Alternative endobiliary operations for choledocholithiasis and papilla of Vater stenosis].

The immediate results of endoscopic papillosphincterotomy (EPST) (n=754) and endobiliary balloon dilatation (n=120) were comparatively analyzed. Survey included patients with choledocholithiasis and papilla Vateri stenosis. The use of balloon dilatation and EPST was defined by the size and amount of gallstones.

[Percutaneous transhepatic papillosphincterotomy and roentgen endobiliary dilatation in cholelithiasis complicated by mechanical jaundice].

A comparative analysis of treatment was made in two groups of patients with cholelithiasis complicated by mechanical jaundice who for certain causes could not be subjected to endoscopic retrograde endobiliary interventions. Percutaneous transhepatic antegrade papillosphincterotomy and endobiliary balloon dilatation extend the possibilities of rendering medical care to this category of patients. The main indications to antegrade interventions are: impossible retrograde cannulation of the major duodenal papilla, impossible endoscopic control of the position of the papillotome in the papilla zone.

Ytterbocenes as one- and two-electron reductants in their reactions with diazadienes: YbIII mixed-ligand bent-sandwich complexes containing a dianion of diazabutadiene.

Ytterbocene [Yb(C(5)MeH(4))(2)(thf)(2)] reacts with diazabutadiene 2,6-iPr(2)C(6)H(3)-N=CH-CH=N-C(6)H(3)iPr(2)-2,6 (DAD) as a one-electron reductant to afford a bis(cyclopentadienyl) Yb(III) derivative containing a DAD radical anion [Yb(C(5)MeH(4))(2)(dad(-.))]. However, ytterbocenes [YbCp*(2)(thf)(2)] (Cp*=C(5)Me(5), C(5)Me(4)H) coordinated by sterically demanding cyclopentadienyl ligands act as two-electron reductants in their reactions with DAD.