Multimodal Temperature Readout Boosts the Performance of CuInS/ZnS Quantum Dot Nanothermometers.

Fluorescent nanothermometers are positioned to revolutionize research into cell functions and provide strategies for early diagnostics. Fluorescent nanostructures hold particular promise to fulfill this potential if nontoxic, stable varieties allowing for precise temperature measurement with high thermal sensitivities can be fabricated. In this work, we investigate the performance of micelle-encapsulated CuInS/ZnS core/shell colloidal quantum dots (QDs) as fluorescent nanothermometers.

The ROS-generating photosensitizer-free NaYF:Yb,Tm@SiOupconverting nanoparticles for photodynamic therapy application.

In this work we adapt rare-earth-ion-doped NaYFnanoparticles coated with a silicon oxide shell (NaYF:20%Yb,0.2%Tm@SiO) for biological and medical applications (for example, imaging of cancer cells and therapy at the nano level). The wide upconversion emission range under 980 nm excitation allows one to use the nanoparticles for cancer cell (4T1) photodynamic therapy (PDT) without a photosensitizer.

Excitation efficiency determines the upconversion luminescence intensity of β-NaYF:Er,Yb nanoparticles in magnetic fields up to 70 T.

Lanthanide-doped nanoparticles enable conversion of near-infrared photons to visible ones. This property is envisioned as a basis of a broad range of applications: from optoelectronics, via energy conversion, to bio-sensing and phototherapy. The spectrum of applications can be extended if magnetooptical properties of lanthanide dopants are well understood.

Yttrium-Doped Iron Oxide Nanoparticles for Magnetic Hyperthermia Applications.

Magnetic nanoparticles of FeO doped by different amounts of Y (0, 0.1, 1, and 10%) ions were designed to obtain maximum heating efficiency in magnetic hyperthermia for cancer treatment. Single-phase formation was evident by X-ray diffraction measurements.

Unmodified Rose Bengal photosensitizer conjugated with NaYF:Yb,Er upconverting nanoparticles for efficient photodynamic therapy.

In photodynamic therapy (PDT), photosensitizer (PS) molecules are irradiated by light to generate reactive oxygen species (ROS), the presence of which subsequently leads to cell death. At present, the modality is limited to the treatment of skin diseases because of the low tissue penetration of visible or ultraviolet light required for producing ROS. To increase tissue penetration and extend the therapeutic possibilities of PDT to the treatment of deep-seated cancer, rare-earth doped nanoparticles capable of up-converting infrared to visible light are investigated.