Publications by authors named "Boris Oklander"
Article Synopsis
- Circulating tumor DNA (ctDNA) can help detect residual cancer after treatment, but its low levels make detection tough; tumor-informed whole-genome sequencing (WGS) offers a solution using numerous mutations for better ctDNA identification.
- * In a study with 144 stage III colorectal cancer patients and 1283 plasma samples, WGS created a unique mutational fingerprint that improved ctDNA detection and demonstrated excellent reproducibility across labs.
- * Results showed that ctDNA detection post-surgery and post-chemotherapy strongly predicted cancer recurrence, often identifying it months before standard imaging; the study highlights the potential for WGS to track cancer evolution and treatment effects.*
Background And Objective: Circulating tumor DNA (ctDNA) can be used for sensitive detection of minimal residual disease (MRD). However, the probability of detecting ctDNA in settings of low tumor burden is limited by the number of mutations analyzed and the plasma volume available. We used a whole-genome sequencing (WGS) approach for ctDNA detection in patients with urothelial carcinoma.
View Article and Find Full Text PDFTransthoracic parametric Doppler (TPD), unlike conventional ultrasonography, measures signals originating from movements of pulmonary blood vessel walls. In this pilot study, we tested TPD in 15 patients diagnosed with pulmonary embolism on computed tomography pulmonary angiography. Results were mapped to the upper, middle, and lower thirds of the right lung.
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