Optimizing Healthcare Expenditure for Spinal Cord Stimulation in Italy: The Value of Battery Longevity Improvement and a Direct-to-Implant Approach.

Spinal cord stimulation (SCS) is a treatment for chronic intractable pain powered by an implantable pulse generator that may be rechargeable or not rechargeable (NR). It is performed in 2 stages (a trialing phase followed by permanent device implantation) and necessitates 2 hospitalizations, which may increase infection risk. This analysis explores the cost impact of improvements in battery longevity and the adoption of 1-step (direct-to-implant [DTI]) SCS implantation.

Evidence for scale-dependent root-antation feedback and its role in halting the spread of a pantropical shrub into an endemic sedge.

Vegetation pattern formation is a widespread phenomenon in resource-limited environments, but the driving mechanisms are largely unconfirmed empirically. Combining results of field studies and mathematical modeling, empirical evidence for a generic pattern-formation mechanism is demonstrated with the clonal shrub L. (hereafter ) on the Brazilian island of Trindade.

Germination of grass species from dry and wet grasslands in response to osmotic stress under present and future temperatures.

Premise: Seed germination is controlled by the soil microclimate, which is expected to change with the temperature increase and rainfall irregularity predicted for the future. Because changes in soil characteristics directly affect species recruitment, vegetation dynamics and resilience, we investigated how caryopses of native grasses from dry and wet grasslands respond to water stress under current and future temperature regimes.

Methods: Caryopses were collected from 10 grass species in dry and wet grasslands, subjected or not to a fire event, and tested for germination at increasing osmotic potential (0 to -1.

Hemodialysis patients and complications management costs in Italy: Plastic cannulae a potentially cost-effective strategy.

Background: The treatment of end-stage chronic renal failure involves substantial costs for health care, which could be higher considering hemodialysis access complications management costs. Complications could be addressed by cannulation technique, but also by the needle. In particular, the use of a metal needle for cannulation is responsible for several complications that compromise dialysis delivery and require interventions.

Fire cues trigger germination and stimulate seedling growth of grass species from Brazilian savannas.

Premise: Although fire cues (high temperatures and smoke) influence seed germination in numerous species from fire-prone environments, their effects on seed germination of species from neotropical savannas are poorly understood.

Methods: We exposed seeds of eight grass species from the Cerrado, the Brazilian savanna to heat-shock (80°C or 110°C for 5 min) and/or smoke water, and then set them to germinate in light or dark, at either summer (28°C/18°C) or winter (27°C/14°C) temperature regimes in an incubator. In addition, we evaluated the effects of smoke water on seedling root and shoot growth for four of the species.

Brazilian Cerrado Mart. Leaves Exhibit Antiplasmodial and Trypanocidal Activities .

Background: The rapid spread of drug-resistant strains of protozoan parasites required the urgent need for new effective drugs. Natural products offer a variety of chemical structures, which make them a valuable source of lead compounds for the development of such new drugs. Cerrado is the second largest biome in Brazil and has the richest flora of all the world savannahs.

Pequi leaves incorporated into the soil reduce the initial growth of cultivated, invasive and native species.

Studies have identified the phytotoxicity of many native species of the Cerrado; however, most of them were conducted either in inert substrates, or using exaggerate proportions of plant material. We investigated the phytotoxicity of pequi leaves added to substrate soil in quantities compatible with the litter produced by this species. Pequi leaves were triturated and added to red latosol in concentrations of 0.

Relative growth rate variation of evergreen and deciduous savanna tree species is driven by different traits.

Background And Aims: Plant relative growth rate (RGR) depends on biomass allocation to leaves (leaf mass fraction, LMF), efficient construction of leaf surface area (specific leaf area, SLA) and biomass growth per unit leaf area (net assimilation rate, NAR). Functional groups of species may differ in any of these traits, potentially resulting in (1) differences in mean RGR of groups, and (2) differences in the traits driving RGR variation within each group. We tested these predictions by comparing deciduous and evergreen savanna trees.

Cost-utility analysis of the EVOLVO study on remote monitoring for heart failure patients with implantable defibrillators: randomized controlled trial.

Background: Heart failure patients with implantable defibrillators place a significant burden on health care systems. Remote monitoring allows assessment of device function and heart failure parameters, and may represent a safe, effective, and cost-saving method compared to conventional in-office follow-up.

Objective: We hypothesized that remote device monitoring represents a cost-effective approach.

[Critical in demolition and removal of asbestos cement materials].

Those involved in the asbestos removal is the main category of workers currently exposed to asbestos in the province of Brescia. Although Italy, since 1991, has special rules for the protection of workers exposed to asbestos, improved further by D. Lgs.

[Occupational risk and work-related diseases on steel foundries].

The iron foundries are still well represented in the area of Brescia and, despite having been involved in a major technological developments, have still risks to the health of workers. In order to verify the state of the art and effectiveness of prevention measures implemented by various companies, in recent years have carried out numerous inspections, environmental monitoring and biological. Furthermore, there were in the regional information system diseases reported and/or by the reported health.

Remote follow-up of pacemakers in a selected population of debilitated elderly patients.

Aims: The majority of patients with pacemakers are very elderly, many being >85-years old. They often suffer from serious illnesses and have great difficulty in walking. The aim of our study was to compare remote pacemaker monitoring with in-home checks of pacemakers, in terms of applicability, efficacy, and cost in a selected population of debilitated elderly patients.

Heat shock effects on seed germination of five Brazilian savanna species.

Fire is considered an important factor in influencing the physiognomy, dynamics and composition of Neotropical savannas. Species of diverse physiognomies exhibit different responses to fire, such as population persistence and seed mortality, according to the fire frequency to which they are submitted. The aim of this study is to investigate the effects of heat shocks on seed germination of Anadenanthera macrocarpa (Benth.

Preferences of patients, their family caregivers and vascular surgeons in the choice of abdominal aortic aneurysms treatment options: the PREFER study.

Objective: Factors influencing the choice between endovascular (endovascular aneurysm repair, EVAR) and open repair (OPEN) of abdominal aortic aneurysm (AAA) are of increasing interest. We quantified their importance among the different subjects involved in the treatment.

Methods: Pre- and postoperative patients (pts), their relatives and vascular surgeons completed questionnaires evaluating six treatment characteristics: anaesthesia; recovery time to basic everyday activities; risk of re-intervention at 5 years (RR); complexity of follow-up; risk of major complications; and additional cost of intervention (AC).

Underdeveloped embryos and germination in Aristolochia galeata seeds.

Aristolochiaceae have been described as having seeds with underdeveloped embryos and morphological or morphophysiological dormancy. Aristolochia galeata is a native climber found in the Cerrado biome, associated with road and gallery forest edges. The aims of this study were to investigate: embryo growth rate, morphology and seed germination parameters under different treatments.

Cost-benefit analysis of supplemented very low-protein diet versus dialysis in elderly CKD5 patients.

Background: Dialysis increases patient life expectancy but is associated with clinically severe and costly complications. Health and economic benefits could derive from postponing dialysis with a supplemented very low-protein diet (sVLPD).

Methods: An economic evaluation was conducted to compare benefits and costs of sVLPD versus dialysis in elderly CKD5 patients.

Patients', physicians', and pharmacists' preferences towards coagulation factor concentrates to treat haemophilia with inhibitors: results from the COHIBA Study.

Despite modern highly efficacious technologies, there is still a lack of consensus on how to optimally treat haemophilia patients with inhibitors. The aim of the study was to evaluate preferences towards the characteristics of different coagulation factor concentrates for haemophilia inhibitors patients, from the perspective of patients or their caregivers, haematologists and pharmacists. A discrete choice study was conducted.

The effect of dextran for hypothermic (10 degrees C) preservation of human fetal lung fibroblasts.

Background: Low-potassium (LP) solution with Dextran (Dx) improves lung preservation. Nevertheless, the role of Dx in simple cold storage is not established yet. This study was designed to investigate the relationship between molecular weight and concentration of Dx in LP solutions and its effects on cell viability after prolonged hypothermic preservation.