A hot and cold tumor‑related prognostic signature for stage II colorectal cancer.

Globally, colorectal cancer (CRC) is one of the most lethal and prevalent malignancies. Based on the presence of immune cell infiltration in the tumor microenvironment, CRC can be divided into immunologically 'hot' or 'cold' tumors, which in turn leads to the differential efficacy of immunotherapy. However, the immune characteristics of hot and cold CRC tumors remain largely elusive, prompting further investigation of their properties regarding the tumor microenvironment.

Sustainable Utilization of Fe(Ⅲ) Isolated from Laterite Hydrochloric Acid Lixivium via Ultrasonic-Assisted Precipitation to Synthesize LiFePO/C for Batteries.

Ultrasonic-assisted precipitation was employed to sustainably isolate Fe in the hydrochloric acid lixivium of low-grade laterite for the synthesis of battery-grade iron phosphate. The recovery efficiency of Ni and Co exceeded 99%, while the removal efficiency of the Fe impurity reached a maximum of 95%. Precipitation parameters for the selective isolation of Fe (MgO precipitant, pH 1, 70-80 °C) were optimized and used in ultrasonic precipitation experiments.

Combined associations of general obesity and central obesity with hypertension stages and phenotypes among children and adolescents in Zhejiang, China.

General and central obesity are suggested to be associated with elevated blood pressure (BP), whereas few studies have investigated their combined associations with hypertension in children. This study aimed to assess the associations of combinations of general obesity and central obesity with hypertension in Chinese children, including its stages and phenotypes. A total of 5430 children aged 7-17 years in Zhejiang Province were enrolled.

Modeling of the Competition between Uranyl Nitrate and Nitric Acid upon Extraction with Tri--butyl Phosphate.

Uranium is a strategic element and plays an important role in energy resources. A HO-HNO-UO(NO)-TBP (tri--butyl phosphate)-diluent system is commonly used for uranium separation and purification in liquid-liquid extraction. Uranyl nitrate is promoted by the existence of nitrate at low HNO concentrations but is inhibited at high HNO concentrations.

Application of a Sustainable Bioderived Solvent (Biodiesel) for Phenol Extraction.

Replacement of volatile organic compound solvents by greener or more environmentally sustainable solvents is becoming increasingly important due to the increasing health and environmental concerns. In the present work, a bioderived solvent, soybean oil methyl ester, which is better known as biodiesel and is a nonvolatile organic compound, was used as a solvent to replace the fossil solvent (kerosene) for phenol extraction. First, biodiesel was selected as an optional solvent to replace kerosene based on Hansen solubility parameter calculation results.

The P-Type ATPase PA1429 Regulates Quorum-Sensing Systems and Bacterial Virulence.

is becoming an increasingly prevalent pathogen, capable of causing numerous life threatening infections in immunocompromised patients. The three hierarchically arranged quorum sensing (QS) systems, namely , and play key roles in coordinating virulence expression in . However, the regulatory mechanisms of the system have not been fully elucidated.