Quinic acid enhances kanamycin efficacy against methicillin-resistant Staphylococcus aureus biofilms.

Background: Methicillin-resistant Staphylococcus aureus (MRSA) form biofilms that contribute to increased antimicrobial resistance, leading to treatment failure and/or relapse. It is, therefore, necessary to develop new antibiofilm strategies to eradicate MRSA biofilms related infections. This study was aimed to evaluate the effect of the combination of quinic acid and kanamycin against the preformed biofilms of methicillin-resistant Staphylococcus aureus.

Exploring Medicinal Plants for Antimicrobial Activity and Synergistic Effects With Doxycycline Against Bacterial Species.

Medicinal plants are rich sources of bioactive compounds with diverse pharmacological properties, including antimicrobial activities. This study aimed to assess the antibiofilm potential of methanol and ethanol extracts from nine selected medicinal plants, as well as their synergistic effects with doxycycline against strains. Standard procedures were employed to determine the phytochemical composition, total phenolic, and flavonoid contents of the extracts.

Antibiofilm Activity of Curcumin and Piperine and Their Synergistic Effects with Antifungals against Clinical Isolates.

Background: Candidiasis is the common name for diseases caused by yeast of the genus . is one of the most implicated species in superficial and invasive candidiasis. Antifungals, polyenes, and azoles have been used to treat candidiasis.

Biofilm Formation, Pyocyanin Production, and Antibiotic Resistance Profile of Isolates from Wounds.

is one of the most frequently resistant and dangerous bacteria isolated from infected wounds of patients. This study aimed to determine the prevalence of from infected wounds of patients in the Dschang District Hospital to evaluate their antibiotic susceptibility profiles and their ability to swarm and swim and correlate pyocyanin production with biofilm formation. Wound swab samples were collected and the identification of was performed using microbiological and biochemical tests.

Antifungal Resistance Profile, Biofilm Formation, and Virulence Factor Production in Candida krusei Isolates From HIV-Infected Patients in Cameroon.

Background Fungal infections mainly caused by are increasing rapidly and represent a serious public health problem in human immunodeficiency virus (HIV)-infected patients. This study aimed to investigate the antifungal susceptibility profile and virulence factors in isolated from HIV-infected patients. Methodology Isolates were identified by biochemical and molecular methods.

Antibiotic-Potentiating Effect of Some Bioactive Natural Products against Planktonic Cells, Biofilms, and Virulence Factors of .

Background: is an opportunistic human pathogen that causes infections that are mediated by both virulence factor production and biofilm formation. In addition, many antibiotics are increasingly losing their efficacy due to the development of resistance. The screening of potentially bioactive natural compounds that have both antivirulence and antibiofilm activities to enhance antibiotic efficacy and reverse antibiotic resistance is a good strategy to overcome these issues.

Antibiotic Resistance Profile, Biofilm Formation Ability, and Virulence Factors Analysis of Three Staphylococcus spp. Isolates From Urine.

Background . is one of the most causative agents of urinary tract infections (UTIs). This study aimed to investigate the antibiotic resistance profile and the virulence factors, including the biofilm formation ability of isolates from urine.

Biofilm Formation and Phospholipase and Proteinase Production in Clinical Isolates and Susceptibility towards Some Bioactive Natural Products.

Background: Cryptococcosis is one of the most common fungal infections in immunocompromised patients, which is caused by . However, relatively little is known about the virulence factors of and the incidence of antifungal drug resistance in is rapidly increasing. This study was undertaken to investigate the virulence factors in , thymol, curcumin, piperine, gallic acid, eugenol, and plumbagin for their potential antimicrobial activity against .

Phytochemical Screening, Antioxidant, and Antimicrobial Activities of Seven Underinvestigated Medicinal Plants against Microbial Pathogens.

Background: Plants are a rich source of therapeutic compounds that have tremendous applications in the pharmaceutical industry. This study aimed to identify the phytochemicals present in the seven selected medicinal plants as well as their antioxidant and antimicrobial activities.

Methods: Phytochemical screening, total phenolic, and flavonoid contents were determined using standard methods.

Antibiofilm Synergistic Activity of Streptomycin in Combination with Thymol-Loaded Poly (Lactic-co-glycolic Acid) Nanoparticles against Isolates.

Background: Thymol is an important component of essential oils found in the oil of thyme, is extracted mainly from , and was shown to act synergistically with streptomycin against biofilms. Additionally, thymol could be encapsulated into poly (lactic-co-glycolic acid) (PLGA) nanoparticles to overcome issues related to its low water solubility and high volatility. The present study aimed to investigate the antibiofilm activity of thymol-loaded PLGA nanoparticles (Thy-NPs) alone and in combination with streptomycin against biofilms of isolates.

Phytochemical Analysis and Antifungal Potentiating Activity of Extracts from Loquat () against Clinical Isolates.

(loquat) has been used in African traditional medicine with numerous beneficial health effects. The extracts from loquat contain several bioactive compounds with a plethora of pharmacological properties. However, a scientific study on the activity against the aetiological agent of cryptococcosis has not yet been reported.