Impact of tick-borne pathogens on the health risk of soldiers.

Introduction And Objective: Vector diseases are common in Europe, including Poland. Every year, 77,000 Europeans are infected with transmissive diseases as a result of contact with infected vectors. In Poland, ticks are vectors of great epidemiological importance.

Effects of 17-β-estradiol released from shape-memory terpolymer rods on sciatic nerve regeneration after injury and repair with chitosan nerve conduit in female rats.

The aim of this study was to assess 17-β-estradiol (E2) influence on sciatic nerve regeneration after injury followed by a repair with chitosan conduit in ovariectomized female rats. The study was performed in 2 groups (n = 16) of rats: OVChit - after excision of a fragment of the sciatic nerve, a chitosan conduit was implanted; OVChitE10 group - additionally to chitosan conduit, shape-memory terpolymer rods based on poly(L-lactide-co-glycolide- co-trimethylene carbonate) releasing 17-β-estradiol for 20 weeks were implanted. The mean number of regenerating axons and mean fiber area were significantly greater in 17-β-estradiol-treated animals.

Association between peroxisome proliferator-activated receptor-alpha, -delta and -gamma gene () polymorphisms and overweight parameters in physically active men.

Peroxisome proliferator-activated receptors (PPARs) have unique functions in energy metabolism regulation but are also involved in regulation of the inflammatory process and obesity. The aim of this study was to analyse potential associations between polymorphisms of (rs1800206), (rs1053049; rs2267668) and (rs1801282) and overweight parameters. One hundred and sixty-six males, unrelated Caucasian military professionals, were recruited in the genetic case-control study conducted in the period 2016-2019.

The interactions between interleukin-1 family genes: IL1A, IL1B, IL1RN, and obesity parameters.

Background: Obesity has been recognized as a worldwide growing problem, producing many pathologies including the promotion of "proinflammatory state." The etiology of human obesity is still only partially understood; however, the genetic background has been proved. Its nature is complex, and currently, it appears that the combined effects of the interactions among multiple genes should receive more attention.

The Role of the Mechanical, Structural, and Thermal Properties of Poly(l-lactide--glycolide--trimethylene carbonate) in the Development of Rods with Aripiprazole.

In this work, we aimed to determine the role of the mechanical, structural, and thermal properties of poly(l-lactide--glycolide--trimethylene carbonate) (P(l-LA:GA:TMC)) with shape memory in the formulation of implantable and biodegradable rods with aripiprazole (ARP). Hot melt extrusion (HME) and electron beam (EB) irradiation were applied in the formulation process of blank rods and rods with ARP. Rod degradation was carried out in a PBS solution.

Polymorphisms Are Not Related to Obesity Parameters in Physically Active Young Men.

Interleukin 6 (IL-6) is a cytokine with both pro- and anti-inflammatory actions, but is also considered as a "metabolic hormone" involved in immune responses, affecting glucose, protein and lipid metabolism. It has been proposed to be related to obesity, but various results have been presented. Thus, in this study, the very homogenous population of young, male military professionals, living in the same conditions involving high physical activity, has been selected to avoid the influence of environmental factors.

Acanthamoeba - pathogen and vector of highly pathogenic bacteria strains to healthy and immunocompromised individuals.

Acanthamoeba is a free-living protist pathogen, which is present in every place on Earth. 50 to 100 percent of the adult population has serum antibodies, specific for Acanthamoeba antigens. Acanthamoeba is an etiological agent of keratitis and encephalitis diagnosed in human.

Designing Biodegradable Wafers Based on Poly(L-lactide-co-glycolide) and Poly(glycolide-co-ε-caprolactone) for the Prolonged and Local Release of Idarubicin for the Therapy of Glioblastoma Multiforme.

Purpose: The blood-brain barrier limits the application of idarubicin in the therapy of glioblastoma multiforme. Biodegradable, intracranial wafers with prolonged release may increase therapy efficiency.

Methods: Blank wafers, wafers containing 5% w/w and 10% w/w of idarubicin were formulated by solution casting from poly(L-lactide-co-glycolide) and poly(glycolide-co-ε-caprolactone).

Electron beam sterilization of implantable rods with risperidone and with 17-β-estradiol: a structural, thermal and morphology study.

Purpose: Poly(L-lactide-co-glycolide-co-trimethylene carbonate) rods with risperidone and 17-β-estradiol were sterilized by electron beam irradiation. The aim of the study was to assess electron beam irradiation impact on terpolymer composition, chain microstructure, glass transition temperature, molecular weight and the morphological features of rods.

Methods: Hot melt extrusion in the formulation of rods was applied.

Susceptibility of Dermacentor reticulatus tick to repellents containing different active ingrediens.

Introduction: Ticks are vectors of human and animal diseases.

Materials And Methods: The aim of this study was to investigate the efficacy of four different formulations containing DEET, Icaridin, IR3535 and mix of three compounds: DEET, IR3535 and geraniol, against Dermacentor reticulatus ticks.

Results: The repellent effectiveness of these products to adult ticks was different.

Formulation of delivery systems with risperidone based on biodegradable terpolymers.

Risperidone is applied in oral dosage formulations in the treatment of mental diseases. Current trends point toward parenteral delivery systems based on poly(lactide-co-glycolide), with wafers or rods being the more attractive option than the routinely used intramuscular suspension with microparticles. The aim of our work was to study the utility of solution casting and hot melt extrusion in the formulation of wafers and rods with risperidone based on terpolymers, namely poly(lactide-co-glycolide-co-trimethylene carbonate) and poly(lactide-co-glycolide-co-ε-caprolactone).

Variations in the Rate of Infestations of Dogs with Zoonotic Nematodes and the Contamination of Soil in Different Environments.

Companion animals are an important aspect in human life. However, they may also be considered a source of pathogens. An example of zoonotic parasitoses is toxocarosis or cutaneous larva migrans (CLM).

Different effects of feeding pregnant and lactating mice aqueous and hydro-alcoholic extracts on their serum angiogenic activity and content of selected polyphenols.

Angiogenesis plays an important role in many physiological processes, among them the formation of tissues and organs during embryogenesis. A lot of medicinal plants exhibit angiomodulatory properties. This creates the need for a thorough check of whether the plant extracts that we would like to give to pregnant women in order to increase their resistance to bacterial or viral infection will have negative effects on angiogenesis, and consequently on fetal development.

Quantifying the risk of zoonotic geohelminth infections for rural household inhabitants in Central Poland.

The objective of this study was to evaluate the risk of soil transmitted zoonotic helminth infections for families with young children, inhabitants of villages in the Mazowieckie Province of Central Poland. Epidemiological survey was conducted at 33 randomly selected households with 2-3 children present. Examination of soil samples from yards surrounding the houses for the presence of geohelminth eggs was conducted, the households were inspected, and family members interviewed using a designed questionnaire.

Shape-Memory Terpolymer Rods with 17-β-estradiol for the Treatment of Neurodegenerative Diseases: an In Vitro and In Vivo Study.

Purpose: Estradiol (E2)-loaded poly(L-lactide-co-glycolide-trimethylenecarbonate) (P(L-LA:GA:TMC)) rods with shape-memory were developed for the treatment of neurodegenerative diseases. Usefulness of the extrusion method in the obtaining process was also considered. The influence of structural and surface properties during hydrolytic degradation was developed.

Angiomodulatory properties of Rhodiola spp. and other natural antioxidants.

Disturbances of angiogenesis and oxidative stress can lead to many serious diseases such as cancer, diabetes or ischemic heart disease. Substances neutralizing oxidative stress are known as antioxidants. They can affect angiogenesis process also, and thus, they modulate therapy results.

The influence of the workplace-related biological agents on the immune systems of emergency medical personnel.

Emergency medical services workers' (EMSWs) acute exposures to many biological agents are frequent and well recognised in their workplaces, as well as occupational diseases resulting from some of these exposures. At the same time, there is only scant information on the adverse effects of chronic exposure to biological hazard factors on the immune systems of EMSWs. In the Polish legislation system, the Ordinance of the Minister of Health about harmful biological agents in the workplace and ways of protecting workers from exposure to those agents is an implement of Directive 2000/54/EC, which deals thoroughly with those issues in European Union Countries.

Risk of soil-transmitted helminth infections on agritourism farms in central and eastern Poland.

Agritourism provides ecological tourist services for urban dwellers in rural areas. Agritourism farms offer space and attractive scenery for people seeking to rest in quiet place and wanting healthy, outdoor recreational activities. The high epidemiological standard of agritourism farms is beneficial for the health of the farm owners and the guests.

Thermal properties and morphology changes in degradation process of poly(L-lactide-co-glycolide) matrices with risperidone.

Determining thermal properties and morphology seems to be useful in the analysis of release and degradation processes form polymeric materials. Risperidone is available in the formulation of a long-acting injection based on poly(D,L-lactide-co-glycolide). Currently, alternative solutions are also offered, i.

Epidemiology of human toxocariasis in Poland - A review of cases 1978-2009.

Toxocariasis is a helminthozoonosis due to the infection of humans with larvae belonging to the Toxocara genus. Humans become infected as a result of accidental consumption of infected eggs containing third stage larvae (L3) nematodes from Toxocara canis or Toxocara cati species. Toxocariasis was recognized for the first time in the early 1950s, and the first cases of toxocariasis in Poland were described a few years later.

Risk of human toxocarosis in Poland due to Toxocara infection of dogs and cats.

The purpose of this paper was to present the current data on the risk of toxocarosis in humans in Poland and to give an overview of the clinical and diagnostic aspects of the disease. The number of reported clinical cases of Toxocara infection in children in Poland in medical literature has increased recently. The results of field surveys aimed to evaluate the soil contamination with geohelminth eggs conducted during the last few years showed that Toxocara is the most common zoonotic agent in urban public sites and in rural settlements.

First report of Trichinella pseudospiralis in Poland, in red foxes (Vulpes vulpes).

Nematode worms of the genus Trichinella are one of the most widespread zoonotic pathogens. Natural transmission between hosts can only occur through the ingestion of infected meat. To date, two Trichinella species are known to be etiological agents of disease among domestic animals and wildlife in Poland: T.

A survey of intestinal helminths in wild carnivores from the Tatra National Park, southern Poland.

From January 2011 to July 2012, 144 faecal samples of wild carnivores from the Tatra National Park were examined to evaluate the prevalence of intestinal helminths--72 of wolves (Canis lupus), 45 of red foxes (Vulpes vulpes), 15 of pine martens (Martes martes) and 12 of brown bears (Ursus arctos). In wolves, monospecific infection with Trichuris vulpis (13.9%), Toxocara canis (6.

Contamination of vegetables, fruits and soil with geohelmints eggs on organic farms in Poland.

The objective of this study was to evaluate the contamination of vegetables, fruits and soil with zoonotic parasite eggs on organic and conventional farms in south-eastern Poland. To evaluate the contamination with eggs of zoonotic parasites, examinations were conducted on 8 conventional and 11 organic farms in south-eastern Poland from May-October in 2008 and 2009. The following fruit and vegetables were selected for the experiment: strawberry, leek, onion, carrot, zucchini, beetroot, parsley, potatoes, celery, rhubarb, lettuce, cabbage, broccoli, pumpkin, young beetroot leaves, cauliflower, French beans, turnip, fennel and sorrel.

[Occurrence of Toxocara spp. eggs in household environment of children with diagnosed toxocariasis in Łódź voivodeship].

Toxocariasis is a zoonosis due to infection of humans by dog or cat roundworm (Toxocara canis, T. cati). Humans become infected by ingestion of infective eggs either from soil, dirty hands, raw fruits and vegetables or larvae from undercooked meat of paratenic hosts.