Second Generation Antipsychotics and Cardiovascular Adverse Effects: Developing Evidence-Based Recommendations for Primary Care Medicine.

Background: Second-generation antipsychotic medications (SGAs) are often used by primary care physicians (PCPs) to treat multiple psychiatric diagnoses. SGAs have been connected to a number of adverse effects, including cardiovascular disease. Currently, there are no published evidence-based recommendations addressing SGAs and cardiotoxicity that are directed toward PCPs.

Reversible cerebral vasoconstriction syndrome secondary to chronic cocaine abuse: Case report.

We describe the case of a 36-year-old male patient with a history of chronic headache who came to the emergency room due to an intense global headache, associated with a tonic-clonic episode and loss of consciousness. A cranial computed tomography revealed subarachnoid hemorrhage without apparent aneurysms and a left temporal hyperdense lesion suggestive of intraparenchymal hematoma on the follow-up computed tomography. Cerebral angiography showed irregularities in the right internal carotid artery, including a pseudoaneurysm and multiple stenoses in pial arteries, which were related to chronic cocaine use.

Proton pump inhibitors and dementia: what association?

Unlabelled: Several recent studies have suggested an association between proton pump inhibitors and the development of cognitive changes.

Objective: To assess the existence of this association.

Methods: A comprehensive literature search was conducted including guidelines, meta-analyses, systematic reviews, observational and experimental studies published between February 2011 and February 2021.

The COMT Val158 Met polymorphism as an associated risk factor for Alzheimer disease and mild cognitive impairment in APOE 4 carriers.

Background: The aim of this study is to examine the influence of the catechol-O-methyltranferase (COMT) gene (polymorphism Val158 Met) as a risk factor for Alzheimer's disease (AD) and mild cognitive impairment of amnesic type (MCI), and its synergistic effect with the apolipoprotein E gene (APOE).A total of 223 MCI patients, 345 AD and 253 healthy controls were analyzed. Clinical criteria and neuropsychological tests were used to establish diagnostic groups.

Up-regulation of cerebral carbonic anhydrase by anoxic stress in piglets.

The resuscitation of asphyxiated babies is associated with changes in cerebral protein synthesis that can influence the neurological outcome. Insufficient gas exchange results in rapid shifts in extracellular and intracellular pH. Carbonic anhydrase (CA) plays an important role in buffering acute changes in pH in the brain.