Publications by authors named "Borchers H"

Background: The introduction of hybrid DRGs on 1 January 2024 is intended to create incentives to perform inpatient urology services, e.g., ureterorenoscopy (URS), on an outpatient basis.

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High costs in the German health care system and a lack of nursing staff make a shift from inpatient to outpatient treatment unavoidable. The new catalogue announced for outpatient surgical procedures will contain up to 50% of all procedures in urology. In anticipation of these major changes, neither hospitals nor medical practices are able to prepare adequately since the precise catalogue, the infrastructural changes required, and the rules of remuneration have not yet been clarified.

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Context: Prostate cancer (PCa) is the most common cancer in men. Permanent interstitial low-dose-rate brachytherapy (LDR-BT) is a short-distance radiation therapy in which low-energy radioactive sources are implanted permanently into the prostate.

Objective: To assess the effectiveness and safety of LDR-BT compared to treatment alternatives in men with localised PCa.

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Background: Localized prostate cancer is a slow growing tumor for many years for the majority of affected men. Low-dose rate brachytherapy (LDR-BT) is short-distance radiotherapy using low-energy radioactive sources. LDR-BT has been recommended for men with low risk localized prostate cancer.

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Changes in haemorheology and haemostasis may contribute to bleeding or thrombosis, which is of concern particularly in surgery. Blood loss itself has a major influence on both parameters being closely involved in the clinical outcome. In order to analyze the underlying interrelations, a prospective study with 122 patients (64 females, 58 males) aged between 18 and 83 years (mean: 51.

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Background And Purpose: The aim of the study was the evaluation of PSA kinetics after different radiotherapy methods.

Materials And Methods: Two-hundred and ninety five patients received external-beam radiotherapy (EBRT; 70.2 Gy; n=135), Ir-192 brachytherapy as a boost to EBRT (HDR-BT; 18 Gy+50.

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Purpose: The aim of the study was to evaluate bowel quality-of-life changes after prostate brachytherapy and the impact of Day 1 vs. Day 30 postimplant dosimetry.

Methods And Materials: In 61 patients, computed tomography (CT) scans were performed at Days 1 and 30 after (125)I brachytherapy.

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Article Synopsis
  • The study explored the impact of age and comorbidities on health-related quality of life (HRQOL) in 528 prostate cancer patients before treatment, using a detailed questionnaire.
  • Increased age was associated with worsening urinary incontinence and sexual function, with significant drops in scores from younger to older age groups.
  • Comorbidities, particularly diabetes, were found to negatively influence both urinary and sexual function; however, the rectal domain scores were unaffected by age or comorbidities.
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Modern LDR brachytherapy has drastically reduced rectal toxicity and decreased the occurrence of rectourethral fistulas to <0.5% of patients. Therefore, symptoms of late-onset sequelae are often ignored initially.

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Background And Purpose: The aim of the study was to compare intra-operative and postplanning at different intervals with special focus on sources placed close to the rectal wall.

Materials And Methods: In 61 consecutive patients, CT scans were performed on day 1 and day 30 after an I-125 implant with stranded seeds. The number of sources < or =7 mm to the rectal wall was determined, and displacements were analyzed.

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Background And Purpose: The aim of the study was to compare quality of life after permanent I-125 brachytherapy (BT) and external beam radiotherapy (EBRT) for prostate cancer.

Materials And Methods: A group of 104 patients (52 in each group) have been surveyed prospectively before EBRT/BT (time A), at the last day of EBRT (70.2-72.

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Purpose: To evaluate seed displacements after permanent prostate brachytherapy considering different prostate levels.

Patients And Methods: In 61 patients, postimplant CT scans were performed 1 day and 1 month after an implant with stranded seeds. Seed and prostate surface displacements were determined relative to pelvic bones.

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Background And Purpose: The aim of the study was to analyze source displacements and dose-volume changes in the first month after a permanent implant.

Materials And Methods: In 51 consecutive patients, CT scans were performed at the postoperative day (day 1) and one month (day 30) after an (125)I implant with stranded seeds. Seed positions were determined relative to pelvic bones for five seeds at the base and five seeds at the apex for each patient (n=510) and compared.

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The perineal approach was used in ten patients for the repair of fistulas involving the bladder or prostatic urethra. In the case of radiotherapy-induced (n=2) or recurrent fistulas (n=4) fecal diversion and interposition of the gracilis muscle was performed. In addition in three patients prostatectomy was performed.

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Objectives: To characterize the kinetics of prostate-specific antigen (PSA) after radiotherapy (RT) and neoadjuvant hormonal therapy (NHT) for localized prostate cancer.

Methods: The PSA kinetics of 75 consecutive patients who had undergone RT and NHT (median time 4 months) were followed up for a minimum of 24 months after treatment. RT included a permanent iodine-125 implant (n = 29), a temporary iridium-192 implant as a boost to external beam RT (n = 21), and sole external beam RT (n = 25).

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We evaluated the accuracy of realtime echocardiography studies conducted via telemedicine (at 384 kbit/s) and prerecorded video studies, by comparing the results with subsequent in-person echocardiography examination performed at follow-up. Between January 2002 and December 2004, there were 769 paediatric echo studies of patients aged one day to 19 years by telemedicine. There were three cases (0.

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Purpose: To determine dosimetric risk factors for increased toxicity after permanent interstitial brachytherapy for prostate cancer.

Patients And Methods: Quality of life questionnaires (Expanded Prostate Cancer Index Composite) of 60 and 56 patients were analyzed after a median posttreatment time of 6 weeks (A-acute) and 16 months (L-late). The corresponding CT scans were performed 30 days after the implant.

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Purpose: To evaluate changes of dose distribution for both the prostate and the surrounding tissues after permanent brachytherapy as monotherapy for prostate cancer.

Patients And Methods: In 35 patients, CT scans were performed before, 1 day after (day 1) and 1 month after the implantation (day 30). Changes of prostate volume, dosimetric parameters, and distances between posterior prostate contour and rectal wall as well as prostate contour and prescription isodose were analyzed.

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Objectives: To characterize the influence of neoadjuvant hormonal therapy (NHT) on health-related quality of life after permanent iodine-125 brachytherapy (BT) for prostate cancer.

Methods: A cross-sectional survey using the Expanded Prostate Cancer Index Composite health-related quality-of-life instrument was administered to 134 consecutive patients a median of 29 months after BT. A separate group of 111 patients with comparable demographic characteristics without any prior treatment for prostate cancer rendered the baseline information (control group).

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Objective: To evaluate the potency in patients after radical perineal prostatectomy with wide excision of both neurovascular bundles.

Material And Methods: In this prospective study, a quality-of-life questionnaire was completed by 128 patients at the preoperative stage, and 6 and 12 months postoperatively. Ten questions concerning the patient's sexuality were included on the pre- and both postoperative questionnaires.

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Article Synopsis
  • The study evaluated the effects of dose-volume-time factors in 64 patients with localized prostate cancer who received high-dose-rate brachytherapy (HDR-BT) alongside external beam radiotherapy (EBRT).
  • Significant correlations were found between higher doses to the urethra and rectum and increased urinary morbidity and rectal bleeding, indicating specific dose limits for better outcomes.
  • The findings suggest that keeping the urethra dose below 15 Gy and the rectal mucosa dose below 6 Gy can help minimize treatment-related morbidity and highlight the importance of patient and treatment factors in managing toxicity.
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The value of DNA image cytometry in the differential diagnosis of 106 T1G3 urothelial carcinomas of the bladder and the long-term prognosis (recurrence-free interval, survival) of the patients was tested in comparison with Ta/T1G1 (n=30) and Ta/T1G2 carcinoma (n=54). Monolayer smears were prepared from three 50-microm-thick sections by a cell separation technique and were stained according to Feulgen. The DNA content of 250 epithelial cells, chosen at random, was determined using a TV-image analysis system CM-1 (Hund, Wetzlar, Germany).

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Lymphadenectomy is an essential part of diagnosis and treatment of the squamous cell carcinoma of the penis. Lymphadenectomy is performed depending on various characteristics of penile cancer such as depth of invasion, tumor grade, invasion into the corpora cavernosa, invasion into vascular and lymphatic vessels. In case the inguinal lymphnodes are not palpable a modified lymphadenectomy is indicated.

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Objectives: To assess, in a prospective study, the incidence of fecal incontinence after radical perineal prostatectomy.

Methods: Bowel symptoms were evaluated with questionnaires mailed to 132 patients preoperatively and 6 months postoperatively, and annually thereafter. All patients had undergone extrafascial perineal prostatectomy for Stage cT1-cT3N0M0 prostate cancer.

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