Publications by authors named "Boran Du"
Background: Multiple myeloma (MM) is a hematological malignancy characterized by bone marrow infiltration and osteolytic tumor formation. Despite advancements in the treatment of this disease, MM remains incurable and often leads to complications, such as multiple myeloma bone disease (MMBD). Surgical intervention is frequently necessary to manage symptoms associated with bone disease, including pain and fractures.
View Article and Find Full Text PDFObjective: The aim of this study was to observe the surgical wound healing process in patients with multiple myeloma who had undergone surgery.
Method: We collected clinical data on patients with multiple myeloma and observed wound healing following surgical therapy. Additionally, we compared the expression of angiogenesis markers in patients with and without multiple myeloma (undergoing surgical excision of other tumour tissues).
Article Synopsis
- CAR-T-cell immunotherapy has improved treatment for multiple myeloma, focusing on various targets like BCMA and CS1, but still faces issues like antigen escape and limited CAR-T cell lifespan.
- A case study featured a patient with recurrent multiple myeloma who developed a problematic tumor in the muscles that persisted even after CAR-T-cell treatment targeting BCMA and CS1, leading to surgical intervention.
- Findings indicated that elevated MYBL2 levels in the tumor tissue might be linked to the ineffectiveness of the dual-target CAR-T therapy, suggesting that high MYBL2 expression is associated with a worse prognosis in such patients.
Background: Although acetaminophen is widely used in women during pregnancy, its safety has not been clearly stated. The study aimed to investigate the association between acetaminophen use and adverse pregnancy outcomes in pregnant women in China.
Methods: We conducted a retrospective cohort study by collecting data on pregnant women who delivered in the Beijing Obstetrics and Gynecology Hospital from January 2018 to September 2023.
Background: We report a case of spine infection with mucormycosis that manifested signs of paraplegia in a patient suffering from disseminated mucormycosis. Timely and effective surgery was performed. A review of the literature is included.
View Article and Find Full Text PDFMultiple myeloma (MM) is a monoclonal malignancy characterized by abnormal proliferation of plasma cells. The disease clinically manifests as anemia, hypercalcemia, renal insufficiencies, and osteolytic damage. Osteolytic damage goes with severe bone pain, spinal instability, and pathological fracture, symptoms that are collectively referred to as multiple myeloma bone disease (MMBD).
View Article and Find Full Text PDFPurpose: The aim is to summarize and evaluate current systematic reviews and meta-analyses on MTHFR polymorphisms in recurrent pregnancy loss (RPL).
Methods: We searched Pubmed and Embase databases and selected in form of PICOS (participants, interventions, comparisons, outcomes, and study design). Our methodology was registered on PROSPERO (CRD42017042762).
[Molecular genetic analysis of mitochondrial DNA C1494T mutation in non-syndromic hearing loss of Chinese population].
Zhonghua Yi Xue Yi Chuan Xue Za Zhi
August 2007
Objective: To conduct a molecular epidemiological survey on the mitochondrial DNA C1494T mutation in non-syndromic hearing loss patients in Chinese population.
Methods: Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) were used to screen the mitochondrial DNA 12S rRNA C1494T mutation in 20 patients with aminoglycoside antibiotic induced hearing loss, 136 sporadic non-syndromic hearing loss patients and 50 probands of pedigrees with non-syndromic hearing loss.
Results: The C1494T mutation did not appear in all cases except for the positive control.