Heavy-heartedness biases your weight perception.

Heavy-heartedness (light-heartedness), among more than two hundred metaphors related to the heart, indicates negative (positive) affects. Although these metaphors are generally understood rhetorically, this study explores whether there is any literal connection between either of these two states and one's perception of weight. Participants who recalled a heavy-heartening (vs.

Hydrogen-bonding-driven enantioselective resolution against the Kazlauskas rule to afford γ-amino alcohols by Candida rugosa lipase.

Most lipases resolve secondary alcohols in accordance with the "Kazlauskas rule" to give the R enantiomers. In a similar manner to other lipases, Candida rugosa lipase (CRL) exhibits R enantioselectivity towards heptan-2-ol, although the enantiomeric ratio (E) is low (E=1.6).

Discovery and the structural basis of a novel p21-activated kinase 4 inhibitor.

Functional versatility and elevated expression in cancers have endowed p21-activated kinase 4 (PAK4) as one of the first-in-class anti-cancer drug target. In this study, a novel PAK4 inhibitor, KY-04031 (N(2)-(2-(1H-indol-3-yl)ethyl)-N(4)-(1H-indazol-5-yl)-6-methoxy-1,3,5-triazine-2,4-diamine), was discovered using a high-throughput screening. Analysis of the complex crystal structure illustrated that both indole and indazole of KY-04031 are responsible for PAK4 hinge interaction.