Publications by authors named "Boone W Evans"
Article Synopsis
- - The study investigates the mechanism of action of a new fatty acid analogue, 8-(2-cyclobuten-1-yl)octanoic acid (DA-CB), suggesting it disrupts the biosynthesis of mycolic acids in mycobacteria, which are crucial for their cell wall integrity.
- - Results indicate that DA-CB likely inhibits a step after the action of a known mycolic acid inhibitor, ethionamide, affecting the production of keto-meromycolic acid and leading to changes in bacterial metabolism.
- - The findings highlight DA-CB as a potential new treatment for tuberculosis, with its "clickable" feature allowing for tracking of the modified fatty acid within cells, aiding in
Despite the low bond strength of the oxygen-oxygen bond, organic peroxides are often surprisingly resistant to cleavage by nucleophiles and reductants. As a result, achieving decomposition under mild conditions can be challenging. Herein, we explore the reactivity of a selection of peroxides toward thiolates, phenyl selenide, Fe(II) salts, and iron thiolates.
View Article and Find Full Text PDF