Publications by authors named "Boo Cheong Khoo"

This article delineates the enhancement of an autonomous navigation and obstacle avoidance system for a quadruped robot dog. Part one of this paper presents the integration of a sophisticated multi-level dynamic control framework, utilizing Model Predictive Control (MPC) and Whole-Body Control (WBC) from MIT Cheetah. The system employs an Intel RealSense D435i depth camera for depth vision-based navigation, which enables high-fidelity 3D environmental mapping and real-time path planning.

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Multiphase flows are encountered in various industries, and the Coriolis flowmeter (CFM) is considered a high potential flowmeter for the metering of these flows. However, the decoupling effect and asymmetrical gas distribution in a CFM might decrease the accuracy of its multiphase flow metering The asymmetry of gas distribution in a CFM and its influence on the metering accuracy have only been qualitatively investigated in a few studies. The present paper quantitatively describes the gas distribution asymmetry in several CFMs under different flow conditions by numerical simulation.

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Numerical simulation is a widely used tool for Coriolis flowmeter (CFM) operation analysis. However, there is a lack of experimentally validated methodologies for the CFM simulation. Moreover, there is no consensus on suitable turbulence models and configuration simplifications.

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Neurorobotic augmentation (e.g., robotic assist) is now in regular use to support individuals suffering from impaired motor functions.

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The aerobatic maneuvers of swifts could be very useful for micro aerial vehicle missions. Rapid arrests and turns would allow flight in cluttered and unstructured spaces. However, these decelerating aerobatic maneuvers have been difficult to demonstrate in flapping wing craft to date because of limited thrust and control authority.

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Background And Objective: This research aimed to present an improved side-vented needle and explore its availability as well as the corresponding irrigation strategy.

Methods: A CFD model was used to simulate the irrigant flow in a simplified prepared round root canal with an apical delta respectively with different needles for irrigation. The needle types include flat end-tip needle, original side-vented needle, and improved side-vented needle.

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Supramolecular hydrogels based on inclusion complexation between cyclodextrins (CDs) and polymers have attracted much interest because of their potential for biomedical applications. It is also attractive to incorporate stimuli-responsive properties into the system to create "smart" hydrogels. Herein, a poly(-isopropylacrylamide) (PNIPAAm) star polymer with a β-CD core and an adamantyl-terminated poly(ethylene glycol) (Ad-PEG) polymer were synthesized.

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The effect of acute irradiation with 5Gy or fractionated exposure with 0.5Gy continuously for 10days (a total dose of 5Gy) was evaluated in an immature BALB/c mouse model. Radioprotective effect of ursolic acid (at 25mg/kg/daily administered 1h after acute or each of fractionated irradiations, and continuously for 30days) was also investigated.

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Animal experimental studies indicate that acute or chronic low-dose ionizing radiation (LDIR) (≤100 mSv) or low-dose-rate ionizing radiation (LDRIR) (<6 mSv/h) exposures may be harmful. It induces genetic and epigenetic changes and is associated with a range of physiological disturbances that includes altered immune system, abnormal brain development with resultant cognitive impairment, cataractogenesis, abnormal embryonic development, circulatory diseases, weight gain, premature menopause in female animals, tumorigenesis and shortened lifespan. Paternal or prenatal LDIR/LDRIR exposure is associated with reduced fertility and number of live fetuses, and transgenerational genomic aberrations.

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Article Synopsis
  • Early brain irradiation can trigger lasting abnormal development, negatively impacting quality of life and leading to cognitive impairment and aging in individuals.
  • Studies on animals show that even low doses of postnatal brain irradiation can hinder neurogenesis and cause neuronal loss, neuroinflammation, and changes in blood vessel formation in the brain.
  • Understanding the molecular effects of radiation, particularly at low doses, could uncover mechanisms behind these negative impacts and inform future diagnostics and therapies to mitigate cognitive decline related to radiation exposure.
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The study of the interaction of bubbles with shock waves and ultrasound is sometimes termed 'acoustic cavitation'. It is of importance in many biomedical applications where sound waves are applied. The use of shock waves and ultrasound in medical treatments is appealing because of their non-invasiveness.

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A boundary integral formulation for the solution of the Helmholtz equation is developed in which all traditional singular behaviour in the boundary integrals is removed analytically. The numerical precision of this approach is illustrated with calculation of the pressure field owing to radiating bodies in acoustic wave problems. This method facilitates the use of higher order surface elements to represent boundaries, resulting in a significant reduction in the problem size with improved precision.

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The concentration dependence of yield stress and dynamic moduli of kaolinite suspensions is studied. Complex electrostatic interactions between kaolinite platelets promote a more liquid-like behavior, with clay particles changing from attractive interactions to a face-face repulsive interaction as the mass fraction of clay particles increases. A yield stress model is developed based on the repulsive interaction between disk-shaped particles, which yields a good prediction of experimental observations when repulsive face-face interaction is dominant.

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Flow supercavitation begins when fluid is accelerated over a sharp edge, usually at the nose of an underwater vehicle, where phase change occurs and causes low density gaseous cavity to gradually envelop the whole object (supercavity) and thereby enabling higher speeds of underwater vehicles. The process of supercavity inception/development by means of "natural cavitation" and its sustainment through ventilated cavitation result in turbulence and fluctuations at the water-vapor interface that manifest themselves as major sources of hydrodynamic noise. Therefore in the present context, three main sources are investigated, namely, (1) flow generated noise due to turbulent pressure fluctuations around the supercavity, (2) small scale pressure fluctuations at the vapor-water interface, and (3) pressure fluctuations due to direct impingement of ventilated gas-jets on the supercavity wall.

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Article Synopsis
  • Fractional flow reserve (FFR) is crucial for guiding coronary interventions but currently requires invasive procedures to obtain.
  • This study introduces a noninvasive method to estimate fractional flow reserve computed tomography (FFRCT) by combining CTA images with computational fluid dynamics (CFD).
  • Results show that FFRCT decreases as diameter stenosis increases, with specific stenosis characteristics impacting its value, and simulations align well with invasive angiography results, suggesting this method could enhance CAD diagnosis.
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In our earlier studies, we have demonstrated that low and high intensity ultrasound can prevent barnacle cyprid settlement. In this study, we found that ultrasound treatment reduced the adhesion of newly metamorphosed barnacles up to 2 days' old. This was observed in the reduction of adhesion strength of the newly settled barnacles from ultrasound treated cyprids on silicone substrate compared to the adhesion strength of barnacles metamorphosed from cyprids not exposed to ultrasound.

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The complex dynamics of a single bubble of a few millimeters in size oscillating inside a narrow fluid-filled gap between two parallel plates is studied using high-speed videography. Two synchronized high-speed cameras were used to observe both the side and front views of the bubble. The front-view images show bubble expansion and collapse with the formation of concentric dark and bright rings.

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Two nonlinear models are proposed to investigate the focused acoustic waves that the nonlinear effects will be important inside the liquid around the scatterer. Firstly, the one dimensional solutions for the widely used Westervelt equation with different coordinates are obtained based on the perturbation method with the second order nonlinear terms. Then, by introducing the small parameter (Mach number), a dimensionless formulation and asymptotic perturbation expansion via the compressible potential flow theory is applied.

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The invasion of red blood cells (RBCs) by malaria parasites is a complex dynamic process, in which the infected RBCs gradually lose their deformability and their ability to recover their original shape is greatly reduced with the maturation of the parasites. In this work, we developed two types of cell model, one with an included parasite, and the other without an included parasite. The former is a representation of real malaria-infected RBCs, in which the parasite is treated as a rigid body.

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We study the forces and torques experienced by pill-shaped Janus particles of different aspect ratios where half of the surface obeys the no-slip boundary condition and the other half obeys the Navier slip condition of varying slip lengths. Using a recently developed boundary integral formulation whereby the traditional singular behavior of this approach is removed analytically, we quantify the strength of the forces and torques experienced by such particles in a uniform flow field in the Stokes regime. Depending on the aspect ratio and the slip length, the force transverse to the flow direction can change sign.

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The effect of cavitation bubbles on the removal of juvenile barnacles was documented using high speed photography. Using spark generated bubbles, the interaction between barnacle and cavitation bubble was examined in detail. The liquid jet generated by the bubble collapse was observed to be directed towards barnacle at different impact intensities, which is related to the dimensionless distance H' (H'=H/Rm), where H is the distance between bubble formation point and the top of barnacle, and Rm is the maximum bubble radius.

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In this study, the effect of high-intensity focused ultrasound (HIFU) on Enterococcus faecalis on both planktonic suspensions and biofilms was investigated. E. faecalis persist in secondary dental infections as biofilms.

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An experimental study of jets and sprays formed by a spark-induced bubble collapsing near a plate with a hole is presented. A Perspex plate with a hole at its center is placed in a half-filled water tank with its top face near the air-water interface. A bubble is created using a low-voltage electrical spark below the hole in the plate.

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Dielectrophoresis (DEP) has been shown to have significant potential for the characterization of cells and could become an efficient tool for rapid identification and assessment of microorganisms. The present work is focused on the trapping, characterization, and separation of two species of Cryptosporidium (C. parvum and C.

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A method to create impacting jets at the micrometer length scale by means of a collapsing cavitation bubble is presented. A focused shock wave from a lithotripter leads to the nucleation of a cavitation bubble below a hole of 25 μm diameter etched in a silicon plate. The plate is placed at an air-water interface.

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