Thermo-Responsive Poly(2-isopropyl-2-oxazoline)-Based Bottlebrush Polymers via Cascade Enyne Metathesis Polymerization.

Poly(2-isopropyl-2-oxazoline) (PiPrOx) is a biocompatible polymer with a temperature-sensitive behavior that exhibits hydrophilic-hydrophobic phase transition in response to temperature changes via lower critical solution temperature (LCST). Typically, the LCST of PiPrOxs changes significantly depending on their molecular weight or concentration. In this study, bottlebrush polymers (PiPrOx-BPs) are created using cascade enyne metathesis polymerization of PiPrOx-based macromonomer.

Strategic approach for converting fat-rich food waste into high-quality biodiesel using black soldier fly larvae for sustainable bioenergy.

Food waste (FW) comprises carbohydrates, proteins, lipids, and water, posing technical challenges for effective treatment and valorisation. This study addresses these challenges by using black soldier fly larvae (BSFL) as a bioconversion medium to transform FW into biodiesel (BD). BSFL predominantly consumed the carbohydrates and proteins in FW (81 wt%), while showing a lower preference for lipids (<50 wt% consumed).

Chiral Acetal-Based Stereo-Controlled Degradable Polymer Synthesis.

The precise synthesis of chiral polymers remains a significant challenge in polymer chemistry, particularly for applications in advanced biomedical and electronic materials. The development of degradable polymers is important for eco-friendly and advanced materials. Here, we introduce a stereo-controlled degradable polymer via cascade enyne metathesis polymerization and enantioselective acetal synthesis through Pd-catalyzed asymmetric hydroamination.

Synthesis of Stereocontrolled Degradable Polymer by Living Cascade Enyne Metathesis Polymerization.

A stereocontrolled degradable polymer was synthesized via living cascade enyne metathesis polymerization. Highly stereodefined N,O-acetal-containing enyne monomers were prepared using the Pd-catalyzed hydroamination of alkoxyallenes and ring-closing metathesis. The resulting chiral polymer exhibited a narrow dispersity window.

Visible Light Photochemical Reactions for Nucleic Acid-Based Technologies.

The expanding scope of chemical reactions applied to nucleic acids has diversified the design of nucleic acid-based technologies that are essential to medicinal chemistry and chemical biology. Among chemical reactions, visible light photochemical reaction is considered a promising tool that can be used for the manipulations of nucleic acids owing to its advantages, such as mild reaction conditions and ease of the reaction process. Of late, inspired by the development of visible light-absorbing molecules and photocatalysts, visible light-driven photochemical reactions have been used to conduct various molecular manipulations, such as the cleavage or ligation of nucleic acids and other molecules as well as the synthesis of functional molecules.

Postoperative residual neuromuscular blockade after reversal based on a qualitative peripheral nerve stimulator response: A randomised controlled trial.

Background: Incomplete recovery of neuromuscular blockade is a common postoperative adverse event in the postanaesthesia care unit.

Objective: We examined and compared the incidence of residual neuromuscular blockade when the recommended dose of neostigmine or sugammadex was administered according to a qualitative nerve stimulator response.

Design: A randomised controlled trial.

Arylalkylamine N-acetyltransferase 1 gene (TcAANAT1) is required for cuticle morphology and pigmentation of the adult red flour beetle, Tribolium castaneum.

In the insect cuticle tanning pathway (sclerotization and pigmentation), the enzyme arylalkylamine N-acetyltransferase (AANAT) catalyzes the acetylation of dopamine to form N-acetyldopamine (NADA), which is one of the major precursors for quinone-mediated tanning. In this study we characterized and investigated the function of TcAANAT1 in cuticle pigmentation of the red flour beetle, Tribolium castaneum. We isolated a full length TcAANAT1 cDNA that encodes a protein of 256 amino acid residues with a predicted GCN5-related acetyltransferase domain containing an acetyl-CoA binding motif.