Publications by authors named "Bonnie Sklar"

Article Synopsis
  • The study investigates a new PRDM5 gene variant linked to brittle cornea syndrome (BCS) in three siblings from a Laotian family, detailing their ophthalmic symptoms like myopia and thin corneas.
  • All three children were found to be homozygous for the PRDM5 variant, and the youngest underwent a corneal transplant due to severe issues, with histopathology showing significant corneal damage.
  • Findings suggest that the novel PRDM5 variant likely causes the observed BCS symptoms, with the surgical challenges also highlighted due to the fragility of the affected tissues.
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Article Synopsis
  • Alkali injuries to the eyes are urgent situations that can lead to serious, long-lasting damage to vision if not treated immediately.
  • Treatment typically focuses on neutralizing the chemical damage, managing inflammation, and helping the eye heal effectively.
  • A case study of a 35-year-old man exposed to sodium hydroxide illustrates successful recovery using an amniotic membrane and a special ring, resulting in improved vision four months later.
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Article Synopsis
  • Over 2.2 billion people worldwide experience vision loss, with one billion cases potentially preventable through better diagnostic methods.
  • Global healthcare costs related to vision impairment reached $255 billion in 2010, projected to rise to $294 billion by 2020, prompting the WHO to set targets for enhanced vision care integration.
  • The review emphasizes the need for innovative, portable vision testing tools and technologies, such as automated screening and machine learning, to improve access to eye care in remote areas.
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Purpose: Despite increasing numbers of women oculoplastic surgeons, they remain underrepresented within the subspecialty. The purpose of this study was to analyze trends in gender authorship within the field of ophthalmic plastic and reconstructive surgery.

Methods: This retrospective observational study sampled articles published in Ophthalmic Plastic and Reconstructive Surgery (OPRS) and Orbit during the years 1985, 1995, 2005, 2015, and 2020.

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Background: The purpose of this case series was to further characterize proteasome inhibitor associated chalazia and blepharitis, to investigate outcomes of different management strategies, and to propose a treatment algorithm for eyelid complications in this patient population.

Methods: This retrospective case series included sixteen patients found to have chalazia and/or blepharitis while receiving proteasome inhibitors for plasma cell disorders at Mount Sinai Hospital in New York, NY from January 2010 through January 2017. Main outcomes were complete resolution of eyelid complications and time to resolution.

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Purpose: To review the clinical features of orbital and choroidal metastases from urothelial carcinomas of the urinary tract among cases reported in the literature, and to describe a case of orbital metastasis from bladder cancer presenting as apparent internuclear ophthalmoplegia.

Methods: Case reports of orbital and choroidal metastases from urothelial carcinomas published in the literature from 1965 to 2018 were reviewed. Data collected included patient demographics, cancer stage and primary site, time to onset of ocular symptoms, length of presenting ocular symptoms, types of primary ocular symptoms, diagnostic imaging, histology, systemic and ocular treatments, and survival time.

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Infertility associated with obesity is characterized by abnormal hormone release from reproductive tissues in the hypothalamus, pituitary, and ovary. These tissues maintain insulin sensitivity upon peripheral insulin resistance. Insulin receptor signaling may play a role in the dysregulation of gonadotropin-releasing hormone (GnRH) secretion in obesity, but the interdependence of hormone secretion in the reproductive axis and the multi-hormone and tissue dysfunction in obesity hinders investigations of putative contributing factors to the disrupted GnRH secretion.

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