CCR5 haplotypes and mother-to-child HIV transmission in Malawi.

Background: CCR5 and CCR2 gene polymorphisms (SNPs) have been associated with protection against HIV transmission in adults and with delayed progression to AIDS. The CCR5 Delta32 deletion and SNP -2459G are associated with reduced expression of the CCR5 protein.

Methodology/principal Findings: We investigated the association between infant CCR2/CCR5 diplotype and HIV mother to child transmission (MTCT) in Malawi.

Cardiac risk underestimation in urban, black women.

Background: Black women have a disproportionately higher incidence of cardiovascular disease mortality than other groups and the reason for this health disparity is incompletely understood. Underestimation of personal cardiac risk may play a role.

Objective: We investigated the personal characteristics associated with underestimating cardiovascular disease in black women.