Efficacy of Intravenous Furosemide Versus a Novel, pH-Neutral Furosemide Formulation Administered Subcutaneously in Outpatients With Worsening Heart Failure.

Objectives: This study sought to determine the efficacy and safety of a novel, pH-neutral formulation of furosemide administered subcutaneously (SC) for treatment of acute decompensated heart failure (HF).

Background: Congestion requiring intravenous (IV) administration of a diuretic agent is the main reason patients with HF present for acute medical care.

Methods: Outpatients presenting with decompensated HF were randomized to receive a single SC or IV dose of furosemide.