Thank You for Changing: Gratitude Promotes Autonomous Motivation and Successful Partner Regulation.

Romantic partners often attempt to improve their relationship by changing each other's traits and behaviors, but such partner regulation is often unsuccessful. We examined whether gratitude expressed by agents (i.e.

Shared Hearts and Minds: Physiological Synchrony During Empathy.

Unlabelled: Empathy is a multidimensional construct that includes changes in cognitive, affective, and physiological processes. However, the physiological processes that contribute to empathic responding have received far less empirical attention. Here, we investigated whether physiological synchrony emerged during an empathy-inducing activity in which individuals disclosed a time of suffering while their romantic partner listened and responded ( = 111 couples).

Listening and the pursuit of communal relationships.

Two motivations linked to developing and maintaining communal relationships include caring for others' welfare and striving to be viewed as a desirable communal relationship partner. We review evidence suggesting that both motivations promote high-quality listening. Furthermore, high-quality listening signals listeners' prosocial motivation and enhances the perceived relational value of both listeners and speakers.

Does Religious Priming Induce Greater Prejudice? A Meta-Analytic Review.

The current meta-analysis addressed whether theistic religious beliefs are causally related to greater prejudice by analyzing 44 studies ( = 11,330) that used experimental designs-priming religion and then measuring negativity toward outgroups (e.g., LGBT and Muslim).

The Benefits of Living With Close Others: A Longitudinal Examination of Mental Health Before and During a Global Stressor.

For better or worse, the people one lives with may exert a powerful influence on one's mental health, perhaps especially during times of stress. The COVID-19 pandemic-a large-scale stressor that prompted health recommendations to stay home to reduce disease spread-provided a unique context for examining how the people who share one's home may shape one's mental health. A seven-wave longitudinal study assessed mental health month to month before and during the pandemic (February through September 2020) in two diverse samples of U.

Feeling Appreciated Predicts Prosocial Motivation in Avoidantly Attached Individuals.

Prosocial motivation is an important ingredient for satisfying relationships. However, individuals high in attachment avoidance-those who fear closeness and prefer independence-often display reduced prosocial motivation for their romantic partner. In two daily experience studies ( = 324), we examined whether feeling appreciated by a romantic partner would buffer this negative link.

When We're Asked to Change: The Role of Suppression and Reappraisal in Partner Change Outcomes.

Receiving a request to change from a romantic partner can evoke intense emotional responses that hinder change progress and conflict resolution. As such, investigating how those being asked to change (i.e.

When the truth helps and when it hurts: How honesty shapes well-being.

Despite honesty being valued in many settings, there is some ambiguity regarding the conditions under which it is beneficial or harmful for individual and relational well-being. We review and evaluate current work linking honesty to well-being. Specifically, we highlight and distinguish associations between honesty and different types of well-being within people, between people, and among broader groups, organizations, and societies.

Lightening the load: Perceived partner responsiveness fosters more positive appraisals of relational sacrifices.

Romantic partners regularly sacrifice their own self-interest when partners' needs and preferences diverge. The present work examines the role of perceived partner responsiveness (PPR)-impressions that one's partner is understanding, caring, and validating-in positively shaping people's appraisals of their relational sacrifices. In Study 1, a preregistered experiment of romantically involved individuals ( = 548), we manipulated PPR (high, low, or control) in a hypothetical sacrifice scenario.

The Distinct Effects of Empathic Accuracy for a Romantic Partner's Appeasement and Dominance Emotions.

When is accurately reading other people's emotions costly and when is it beneficial? We aimed to identify whether the association between empathic accuracy and both relationship quality and motivation to change varies depending on the type of emotion being detected: appeasement (e.g., embarrassment) or dominance (e.

Rosmarinic Acid/ Blue Light Combination Treatment Inhibits Head and Neck Squamous Cell Carcinoma .

Background/aim: This study investigated a novel combined therapy of rosmarinic acid (RA)/blue light on head and neck squamous cell carcinoma (HNSCC) cell proliferation in vitro.

Materials And Methods: HNSCC cells were exposed to BL (500 mW/cm) for 90 s, and incubated with 80 μg/ml RA for 1 hour. Cell viability was determined after 24 h using WST-1 assay.

Synthetic TRuC receptors engaging the complete T cell receptor for potent anti-tumor response.

T cells expressing CD19-targeting chimeric antigen receptors (CARs) reveal high efficacy in the treatment of B cell malignancies. Here, we report that T cell receptor fusion constructs (TRuCs) comprising an antibody-based binding domain fused to T cell receptor (TCR) subunits can effectively reprogram an intact TCR complex to recognize tumor surface antigens. Unlike CARs, TRuCs become a functional component of the TCR complex.

Communal motivation and well-being in interpersonal relationships: An integrative review and meta-analysis.

The motivation to care for the welfare of others, or communal motivation, is a crucial component of satisfying interpersonal relationships and personal well-being. The current meta-analysis synthesized 100 studies (Ntotal = 26,645) on communal motivation to establish its associations with subjective personal well-being (e.g.

The Costs of Suppressing Negative Emotions and Amplifying Positive Emotions During Parental Caregiving.

How do parents feel when they regulate their emotional expressions in ways that are incongruent with their genuine feelings? In an experimental study, parents reported experiencing lower authenticity, emotional well-being, relationship quality, and responsiveness to their children's needs when they recalled caregiving experiences in which they suppressed negative emotions and amplified positive emotions, relative to a control condition. In a 10-day daily experience study, parents tended to use both regulation strategies simultaneously. In addition, assessing their unique effects indicated that positive emotion amplification, but not negative emotion suppression, had an indirect effect on parental outcomes via authenticity, with negative emotion suppression no longer being costly.

The brief aggression questionnaire: psychometric and behavioral evidence for an efficient measure of trait aggression.

A key problem facing aggression research is how to measure individual differences in aggression accurately and efficiently without sacrificing reliability or validity. Researchers are increasingly demanding brief measures of aggression for use in applied settings, field studies, pretest screening, longitudinal, and daily diary studies. The authors selected the three highest loading items from each of the Aggression Questionnaire's (Buss & Perry, 1992) four subscales--Physical Aggression, Verbal Aggression, anger, and hostility--and developed an efficient 12-item measure of aggression--the Brief Aggression Questionnaire (BAQ).

KPT-330 inhibitor of CRM1 (XPO1)-mediated nuclear export has selective anti-leukaemic activity in preclinical models of T-cell acute lymphoblastic leukaemia and acute myeloid leukaemia.

This study explored the anti-leukaemic efficacy of novel irreversible inhibitors of the major nuclear export receptor, chromosome region maintenance 1 (CRM1, also termed XPO1). We found that these novel CRM1 antagonists, termed SINE (Selective Inhibitors of Nuclear Export), induced rapid apoptosis at low nanomolar concentrations in a panel of 14 human T-cell acute lymphoblastic leukaemia (T-ALL) cell lines representing different molecular subtypes of the disease. To assess in vivo anti-leukaemia cell activity, we engrafted immunodeficient mice intravenously with the human T-ALL MOLT-4 cells, which harbour activating mutations of NOTCH1 and NRAS as well as loss of function of the CDKN2A, PTEN and TP53 tumour suppressors and express a high level of oncogenic transcription factor TAL1.