Publications by authors named "Boniface Echefu"
Article Synopsis
- Animal models are crucial for advancing our understanding and treatment of human diseases, particularly neuropsychiatric disorders like autism spectrum disorder (ASD).
- Developing these models requires effective tools to measure and translate human behaviors into observable actions in animals, focusing on key ASD symptoms such as impaired social interactions and communication deficits.
- Various approaches, including exposure to certain chemicals and genetic manipulation, have been used to create rodent models that replicate the complex behaviors associated with ASD, aiding in research on its causes and potential therapies.
Valproic acid (VPA) is a very effective anticonvulsant and mood stabilizer with relatively few side effects. Being an epigenetic modulator, it undergoes clinical trials for the treatment of advanced prostatic and breast cancer. However, in pregnancy, it seems to be the most teratogenic antiepileptic drug.
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