PldA modulates TNFR1-mediated p38 signaling pathways to regulate macrophage responses for its survival.

, a dominant member of the gastric microbiota was associated with various gastrointestinal diseases and presents a significant challenge due to increasing antibiotic resistance. This study identifies 's phospholipase A (PldA) as a critical factor in modulating host macrophage responses, facilitating 's evasion of the immune system and persistence. PldA alters membrane lipids through reversible acylation and deacylation, affecting their structure and function.

Adaptive cascaded transformer U-Net for MRI brain tumor segmentation.

Brain tumor segmentation on magnetic resonance imaging (MRI) plays an important role in assisting the diagnosis and treatment of cancer patients. Recently, cascaded U-Net models have achieved excellent performance via conducting coarse-to-fine segmentation of MRI brain tumors. However, they are still restricted by obvious global and local differences among various brain tumors, which are difficult to solve with conventional convolutions.

Vibrational and electrochemical studies of pectin-a candidate towards environmental friendly lithium-ion battery development.

Pectin polymers are considered for lithium-ion battery electrodes. To understand the performance of pectin as an applied buffer layer, the electrical, magnetic, and optical properties of pectin films are investigated. This work describes a methodology for creating pectin films, including both pristine pectin and Fe-doped pectin, which are optically translucent, and explores their potential for lithium-ion battery application.

Correlation between connexin and traumatic brain injury in patients.

Background: Identification of molecular alterations of damaged tissue in patients with neurological disorders can provide novel insight and potential therapeutic target for treatment of the diseases. It has been suggested by animal studies that connexins (CXs), a family of gap junction proteins, could contribute to neuronal cell death and associate with neurological deficits during trauma-induced damage. Nevertheless, whether specific CXs are involved in traumatic brain injury (TBI) has remained unexplored in human patients.

Resveratrol inhibits lung cancer growth by suppressing M2-like polarization of tumor associated macrophages.

In cancer, tumor associated macrophages (TAMs) play an important role in the cancer progression, evasion of immunity and dissemination of cancer cells. Inhibition of the activation or the M2 polarization of TAMs is an effective therapy for cancer. In the present study, we investigated the ability of resveratrol (RES) to inhibit lung cancer growth using in vitro and in vivo studies, and examined the underlying mechanisms.