Publications by authors named "Bong-Oh Kim"
Article Synopsis
- - The study evaluated the accuracy of a new active robotic system (CUVIS Joint by CUREXO) for total knee arthroplasty (TKA) using three cadaveric specimens (six knees) and was conducted by three surgeons with varying experience in robotic procedures.
- - Results showed that the robotic system achieved a cutting depth accuracy of less than 1.0 mm and resection angle accuracy of less than 1.0 degree, with no significant differences between the planned and actual resection parameters.
- - The findings suggest this robotic system is highly accurate for bone resection in TKA, indicating its potential for clinical use, which was supported by a postoperative hip-knee-ankle angle of just 0
Purpose: In this study, we have prepared a novel polymeric drug delivery system comprised of ionically fixed polymeric nanoparticles (IFPN) and investigated their potential as a drug carrier for the passive targeting of water-insoluble anticancer drugs.
Materials And Methods: For this purpose, the physicochemical characteristics of the IFPN were investigated by comparing them with conventional polymeric micelles. IFPN containing paclitaxel were prepared and evaluated for in vitro stability and in vivo pharmacokinetics.
A mixed polymeric micelle formulation of itraconazole (ITZ-PM) was prepared using monomethoxy poly(ethylene glycol)-b-poly(lactic acid) and poly(lactic acid) as drug carrier materials. The ITZ-PM formulation remarkably increased the itraconazole solubility up to 15 mg/mL in aqueous media and provided stable solutions at a wide range of concentrations and pH's. In toxicity studies of single and 28-day repeated administrations to rats and dogs, ITZ-PM was well tolerated at dose levels corresponding to clinical doses.
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