The traditional drug Gongjin-Dan ameliorates chronic fatigue in a forced-stress mouse exercise model.

Ethnopharmacological Relevance: Gongjin-Dan is a representative traditional Oriental medicine herbal drug that has been used to treat chronic fatigue symptoms for several hundred years. We evaluated the anti-fatigue effects of Gongjin-Dan and the underlying mechanisms in a chronic forced exercise mouse model.

Methods And Materials: Balb/C male mice underwent an extreme treadmill-based running stress (1-h, 5 days/week), and daily oral administration of distilled water, Gongjin-Dan (100, 200, or 400 mg/kg), or ascorbic acid (100 mg/kg) for 28 days.

A prospective study on the safety of herbal medicines, used alone or with conventional medicines.

Ethnopharmacological Relevance: Along with increase of herbal medicine use worldwide, the safety of traditional herbal medicines frequently becomes a medical issue.

Aim Of The Study: This study aimed to investigate the incidence of herbal medicine-induced adverse effects on liver functions.

Subjects And Methods: A prospective study was performed with 313 inpatients (87 male and 226 female) receiving herbal prescriptions during hospitalization.