Speckled-speckle field as a resource for imaging techniques.

Correlated states of light, both classical and quantum, can find useful applications in the implementation of several imaging techniques. Among the employed sources, pseudo-thermal states, generated by the passage of a laser beam through a diffuser, represent the standard choice. To produce light with a higher level of correlation, in this work we consider and characterize the speckled-speckle field obtained with two diffusers using both a numerical simulation and an experimental implementation.

Efficient Implementation of Discrete-Time Quantum Walks on Quantum Computers.

Quantum walks have proven to be a universal model for quantum computation and to provide speed-up in certain quantum algorithms. The discrete-time quantum walk (DTQW) model, among others, is one of the most suitable candidates for circuit implementation due to its discrete nature. Current implementations, however, are usually characterized by quantum circuits of large size and depth, which leads to a higher computational cost and severely limits the number of time steps that can be reliably implemented on current quantum computers.

Generation of Pseudo-Random Quantum States on Actual Quantum Processors.

The generation of a large amount of entanglement is a necessary condition for a quantum computer to achieve quantum advantage. In this paper, we propose a method to efficiently generate pseudo-random quantum states, for which the degree of multipartite entanglement is nearly maximal. We argue that the method is optimal, and use it to benchmark actual superconducting (IBM's ) and ion trap (IonQ's ) quantum processors.

Correcting Coherent Errors by Random Operation on Actual Quantum Hardware.

Characterizing and mitigating errors in current noisy intermediate-scale devices is important to improve the performance of the next generation of quantum hardware. To investigate the importance of the different noise mechanisms affecting quantum computation, we performed a full quantum process tomography of single qubits in a real quantum processor in which echo experiments are implemented. In addition to the sources of error already included in the standard models, the obtained results show the dominant role of coherent errors, which we practically corrected by inserting random single-qubit unitaries in the quantum circuit, significantly increasing the circuit length over which quantum computations on actual quantum hardware produce reliable results.

Feasibility of a Novel Quantum Communication Protocol in Jerlov Type I Water.

Underwater communication based on the use of optical quantum resources has attracted a lot of attention in the last five years due to the potential advantages offered by quantum states of light. In this context, we propose to operate in the mesoscopic intensity regime, where the optical states are well populated and the employed detectors have photon-number resolution. By exploiting these features, we demonstrate that a novel communication protocol based on the experimental quantification of nonclassicality of mesoscopic twin-beam states can be used to transmit binary signals encoded in two single-mode pseudothermal states with different mean values through a Jerlov type I water channel.

Towards underwater quantum communication in the mesoscopic intensity regime.

The problem of secure underwater communication can take advantage of the exploitation of quantum resources and novel quantum technologies. At variance with the current experiments performed at the single photon level, here we propose a different scenario involving mesoscopic twin-beam states of light and two classes of commercial photon-number-resolving detectors. We prove that twin-beam states remain nonclassical even if the signal propagates in tubes filled with water, while the idler is transmitted in free space.

Novel scheme for secure data transmission based on mesoscopic twin beams and photon-number-resolving detectors.

Quantum resources can improve the quality and security of data transmission. A novel communication protocol based on the use of mesoscopic twin-beam (TWB) states of light is proposed and discussed. The message sent by Alice to Bob is encoded in binary single-mode thermal states having two possible mean values, both smaller than the mean value of the TWB.

Effect of noisy channels on the transmission of mesoscopic twin-beam states.

Quantum properties of light, which are crucial resources for quantum technologies, are quite fragile in nature and can be degraded and even concealed by the environment. We show, both theoretically and experimentally, that mesoscopic twin-beam states of light can preserve their nonclassicality even in the presence of major losses and different types of noise, thus suggesting their potential usefulness to encode information in quantum communication protocols. We develop a comprehensive general analytical model for a measurable nonclassicality criterion and find thresholds on noise and losses for the survival of entanglement in the twin beam.

Double-stranded flanking ends affect the folding kinetics and conformational equilibrium of G-quadruplexes forming sequences within the promoter of KIT oncogene.

G-quadruplexes embedded within promoters play a crucial role in regulating the gene expression. KIT is a widely studied oncogene, whose promoter contains three G-quadruplex forming sequences, c-kit1, c-kit2 and c-kit*. For these sequences available studies cover ensemble and single-molecule analyses, although for kit* the latter were limited to a study on a promoter domain comprising all of them.

Dynamical Localization Simulated on Actual Quantum Hardware.

Quantum computers are invaluable tools to explore the properties of complex quantum systems. We show that dynamical localization of the quantum sawtooth map, a highly sensitive quantum coherent phenomenon, can be simulated on actual, small-scale quantum processors. Our results demonstrate that quantum computing of dynamical localization may become a convenient tool for evaluating advances in quantum hardware performances.

Optimizing Silicon photomultipliers for Quantum Optics.

Silicon Photomultipliers are potentially ideal detectors for Quantum Optics and Quantum Information studies based on mesoscopic states of light. However, their non-idealities hampered their use so far. An optimal mode of operation has been developed and it is presented here, proving that this class of sensors can actually be exploited for the characterization of both classical and quantum properties of light.

Measuring nonclassicality with silicon photomultipliers.

Detector stochastic deviations from an ideal response can hamper the measurement of quantum properties of light, especially in the mesoscopic regime where photon-number resolution is required. We demonstrate that, by proper analysis of the output signal, nonclassicality of twin-beam states can be detected and exploited with commercial and cost-effective silicon-based photon-number-resolving detectors.

Time-Resolved Photoluminescence Microscopy Combined with X-ray Analyses and Raman Spectroscopy Sheds Light on the Imperfect Synthesis of Historical Cadmium Pigments.

Recent studies have shown that modern pigments produced after the Second Industrial Revolution are complex systems characterized by a high level of heterogeneities. Therefore, it is fundamental to adopt a multianalytical approach and highly sensitive methods to characterize the impurities present within pigments. In this work we propose time-resolved and spectrally resolved photoluminescence (PL) microscopy for the mapping of luminescent crystal defects and impurities in historical cadmium-based pigments.

Antibunching-like behavior of mesoscopic light.

We present the implementation of a compact setup for the generation of sub-Poissonian states of light exhibiting the analogous of antibunching behavior in the so-called mesoscopic intensity domain. In the scheme, the idler arm of a pulsed multi-mode twin-beam state is directly measured by a photon-number-resolving detector, whereas the signal arm is divided at a balanced beam splitter, at whose outputs other two photon-number-resolving detectors measure the number of photons. The three detectors measure synchronous with each laser pulse.

Homodyne-like detection for coherent state-discrimination in the presence of phase noise.

We propose a homodyne-like detection scheme involving photon-number-resolving detectors to discriminate between two coherent states affected by either uniform or gaussian phase noise. A proof-of-principle experiment is performed employing two hybrid photodetectors, whose outputs are used in post processing to calculate the shot-by-shot photon-number differences. The performance of the strategy is quantified in terms of the error probability in discriminating the noisy coherent signals as a function of the characteristic noise parameters.

Entanglement and nonclassicality in four-mode Gaussian states generated via parametric down-conversion and frequency up-conversion.

Multipartite entanglement and nonclassicality of four-mode Gaussian states generated in two simultaneous nonlinear processes involving parametric down-conversion and frequency up-conversion are analyzed assuming the vacuum as the initial state. Suitable conditions for the generation of highly entangled states are found. Transfer of the entanglement from the down-converted modes into the up-converted ones is also suggested.

Phase-reference monitoring in coherent-state discrimination assisted by a photon-number resolving detector.

Phase estimation represents a crucial challenge in many fields of Physics, ranging from Quantum Metrology to Quantum Information Processing. This task is usually pursued by means of interferometric schemes, in which the choice of the input states and of the detection apparatus is aimed at minimizing the uncertainty in the estimation of the relative phase between the inputs. State discrimination protocols in communication channels with coherent states also require the monitoring of the optical phase.

Internal dynamics of intense twin beams and their coherence.

The dynamics of intense twin beams in pump-depleted parametric down-conversion is studied. A generalized parametric approximation is suggested to solve the quantum model. Its comparison with a semiclassical model valid for larger twin-beam intensities confirms its applicability.

Spatial and spectral coherence in propagating high-intensity twin beams.

Spatial and spectral coherence of high-intensity twin-beam states propagating from the near-field to the far-field configurations is experimentally investigated by measuring intensity auto- and cross-correlation functions. The experimental setup includes a moving crystal and an iCCD camera placed at the output plane of an imaging spectrometer. Evolution from the tight near-field spatial position cross-correlations to the far-field momentum cross-correlations, accompanied by changeless spectral cross-correlations, is observed.

Effects of non-CpG site methylation on DNA thermal stability: a fluorescence study.

Cytosine methylation is a widespread epigenetic regulation mechanism. In healthy mature cells, methylation occurs at CpG dinucleotides within promoters, where it primarily silences gene expression by modifying the binding affinity of transcription factors to the promoters. Conversely, a recent study showed that in stem cells and cancer cell precursors, methylation also occurs at non-CpG pairs and involves introns and even gene bodies.

Direct detection of super-thermal photon-number statistics in second-harmonic generation.

Changes in the statistical properties of light undergoing second-harmonic generation are investigated in the photon-number-resolving domain. We theoretically demonstrate that when a portion of multimode thermal light produced by parametric down-conversion is up-converted, both the second-harmonics and the residual beam at the fundamental wavelength are endowed with super-thermal photon-number distributions. The experimental results, which were obtained by exploiting the photo-number-resolving capability of hybrid photodetectors, are in excellent agreement with the theoretical expectations.

Full genotyping of a highly polymorphic human gene trait by time-resolved fluorescence resonance energy transfer.

The ability of detecting the subtle variations occurring, among different individuals, within specific DNA sequences encompassed in highly polymorphic genes discloses new applications in genomics and diagnostics. DQB1 is a gene of the HLA-II DQ locus of the Human Leukocyte Antigens (HLA) system. The polymorphisms of the trait of the DQB1 gene including codons 52-57 modulate the susceptibility to a number of severe pathologies.

Elucidation of the relationships between H-bonding patterns and excited state dynamics in cyclovalone.

Cyclovalone is a synthetic curcumin derivative in which the keto-enolic system is replaced by a cyclohexanone ring. This modification of the chemical structure might in principle result in an excited state that is more stable than that of curcumin, which in turn should produce an enhanced phototoxicity. Indeed, although curcumin exhibits photosensitized antibacterial activity, this compound is characterized by very fast excited-state dynamics which limit its efficacy as a photosensitizer.

Spatial properties of twin-beam correlations at low- to high-intensity transition.

It is shown that spatial correlation functions measured for correlated photon pairs at the single-photon level correspond to speckle patterns visible at high intensities. This correspondence is observed for the first time in one experimental setup by using different acquisition modes of an intensified CCD camera in low and high intensity regimes. The behavior of intensity auto- and cross-correlation functions in dependence on pump-beam parameters including power and transverse profile is investigated.

Time-resolved fluorescence studies of fullerene derivatives.

Fullerene (nano-C60) and its water-soluble derivatives have several clinical applications including use as a drug carrier to bypass the blood-ocular and blood-brain barriers. However, in vitro and in vivo detection of these nanomaterials is limited by their very low fluorescence quantum yield. The accumulation of fullerene and its derivatives in cells is particularly difficult to measure using standard fluorescence microscopy because their fluorescence is barely detectable in aqueous media.