Scanning laser ophthalmoscopy as a tool for detecting atrophy of the central retinal nerve fibre layer in Leber's hereditary optic neuropathy.

Purpose: To study the central retinal nerve fibre layer with scanning laser ophthalmoscopy (SLO) in subjects with Leber's hereditary optic neuropathy (LHON), a disease primarily affecting retinal nerve fibres in the macular area.

Methods: SLO was performed using combinations of laser wavelengths and aperture settings in subjects with LHON and in age-matched normal controls.

Results: Six subjects with LHON were examined.

Confocal fundus imaging with a scanning laser ophthalmoscope in eyes with cataract.

Aims/background: The study aimed to determine the influence of increased intraocular light scatter on the contrast in scanning laser ophthalmoscope (SLO) images and to examine to what extent SLO images can visualise the fundus through media opacities due to cataract.

Methods: Intraocular light scatter was estimated from measurements of letter contrast sensitivity before and after cataract surgery in five eyes. SLO images were obtained before and after surgery using confocal apertures of 1, 2, 4, and 10 mm, at laser wavelengths of 633 and 780 nm.