Publications by authors named "Bonatz K"
COVID-19 in patients with hematological diseases is associated with a high mortality. Moreover, preventive vaccination demonstrated reduced efficacy and the knowledge on influencing factors is limited. In this single-center study, antibody levels of the SARS-CoV-2 spike protein were measured ≥ 2 weeks after 2nd COVID-19 vaccination with a concentration ≥ 0.
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- Myelofibrosis (MF) is a serious blood cancer that leads to low blood cell counts and various symptoms, especially in patients with low platelet levels (thrombocytopenia).
- A study examined the quality of life and symptom severity in 418 MF patients, showing that those with thrombocytopenia had significantly worse symptoms and higher total symptom scores compared to those without.
- Patients with severe thrombocytopenia faced even higher risks of anemia and other complications, highlighting the need for improved treatment options for these individuals.
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- - The study investigates how gender affects the symptoms and complications of myeloproliferative neoplasms (MPNs), which include polycythemia vera, essential thrombocythemia, and myelofibrosis, involving 2,006 patients.
- - Findings reveal that females are more likely to experience severe and frequent symptoms compared to males, despite similar quality of life scores, with women particularly reporting worse abdominal and microvascular symptoms.
- - Males, on the other hand, are more likely to have polycythemia vera and experience complications such as thrombocytopenia and greater red blood cell transfusion requirements, along with shorter disease duration.
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- Polycythemia vera (PV) is a condition linked to serious health issues and unpleasant symptoms, and JAK inhibitor therapy has shown promise for patients who have previously used hydroxyurea (HU) and experience symptoms like splenomegaly.
- A study evaluated 1,334 PV patients to investigate how previous HU use, phlebotomy needs, and splenomegaly contribute to symptom severity.
- Findings revealed that each of these factors is associated with a significant symptom burden, and having more than one feature increases the severity of symptoms, highlighting that patients with any of these issues experience considerable discomfort.
Article Synopsis
- The study focused on developing an abbreviated symptom score (MPN-SAF TSS) to assess and track the most relevant symptoms experienced by patients with myeloproliferative neoplasms (MPNs), aiming to improve treatment outcomes.
- Analysis included 1,408 MPN patients and revealed significant differences in symptom scores across different MPN subtypes, with a strong correlation to overall quality of life and internal consistency.
- The MPN-SAF TSS showed potential as a reliable tool for measuring symptom burden in MPN patients, making it valuable for evaluating treatment responses in future studies.
Background: The soluble transferrin receptor (sTfR) is established as a test for iron deficiency (ID). In chronic lymphocytic leukemia (CLL), sTfR is not reliable for screening for ID as the latter is strongly dependent on tumor burden.
Methods: We investigated whether the influence of the tumor load can be excluded or minimized using the sTfR/log ferritin ratio (TfR-F-Index) and the C-reactive protein (CRP)-adjusted TfR-F-Index in 87 patients with CLL.
Gram-negative bacterial pneumonia with secondary aspergillosis in an AIDS patient.
Klin Wochenschr
November 1991
A 40-year-old, HIV-infected female patient received antibiotic treatment for a urinary tract infection. After the initial success of therapy and a symptom-free period, she developed pneumonia with septic shock and adult respiratory distress syndrome (ARDS). In spite of intensive care and respirator therapy with positive end-expiratory pressure (PEEP), she died of infectious toxic shock.
View Article and Find Full Text PDFThree years after diagnosis of chronic lymphocytic leukaemia in a 57 year old man developed a hypercalcaemia with multiple bone fractures, concomitant an increase of activity of the leukaemia. There was no hyperparathyroidism, nor in serum, nor inside the lymphocytes. The osteopenia was caused by leukaemic infiltrations.
View Article and Find Full Text PDF[Clinical and hematologic complete remissions of blastic leukoses in adults].
Verh Dtsch Ges Inn Med
August 1968