Publications by authors named "Bonanni M"

Unlabelled: The objective of this study is to evaluate whether early hypoglycemia is an independent risk factor for 2-year cognitive (COG) impairment in small for gestational age (SGA) preterm infants with gestational age (GA) < 32 weeks. We retrospectively reviewed data of 1364 preterm infants with a GA 24-31 weeks. Infants were classified based on blood glucose concentrations within the first 6 h of life (HOL) as < or ≥ 40 mg/dL (Glyc < 40 and Glyc ≥ 40, respectively) and subsequently by birth weight z-score as SGA or appropriate for gestational age (AGA).

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  • iTTP is a serious blood disorder caused by antibodies that affect clotting, and caplacizumab is a new treatment approved for acute cases, used alongside plasma exchange and immunosuppression.
  • A study involving 38 iTTP patients across six Italian medical centers showed that caplacizumab led to rapid normalization of platelet counts, with a median recovery time of just 2 days.
  • The use of caplacizumab resulted in fewer exacerbations and relapses, shorter hospital stays, and no severe side effects, highlighting its effectiveness compared to traditional treatments.
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Transcatheter treatments for structural heart disease, including edge-to-edge mitral valve repair (mTEER), heavily rely on transoesophageal echocardiography (TOE) for pre-procedural assessment and guidance. Trans-septal puncture (TSP) is one of the first key steps of such procedures, with two-dimensional (2D) TOE often providing suboptimal imaging. Three-dimensional (3D) echocardiography could overcome the limitations of 2D TOE and improve the assessment of tenting height.

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  • - Cardiac device infections (CDIs) pose serious health risks for patients with implanted devices, leading to higher rates of illness, longer hospital stays, and increased healthcare costs.
  • - Managing CDIs effectively requires a mix of suitable antibiotic treatments and preventive methods to decrease infection risk, with a special focus on antibiotic prophylaxis and new delivery systems.
  • - This review outlines various prophylactic treatments and antibiotic regimens for CDIs, highlighting the importance of early diagnosis and tailored antibiotic choices for better treatment outcomes.
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Introduction: Recent studies have shown gender differences in cardiovascular outcomes after left atrial appendage closure (LAAC), highlighting different complication rates and adverse events, particularly in short-term assessments. As a result, there remains a significant knowledge gap on how these differences directly impact the efficacy and safety of LAAC procedures. The aim of this retrospective study was to investigate the clinical outcomes of LAAC in women and men using the Watchman FLX device.

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: The mismatch between tricuspid valve (TV) leaflet length and annulus dilation, assessed with the septal-lateral leaflet-to-annulus index (SL-LAI), predicts residual tricuspid regurgitation (TR) following tricuspid transcatheter edge-to-edge-repair (T-TEER). When posterior leaflet grasping is required, the anterior-posterior leaflet-to-annulus index (AP-LAI) may offer additional information. : This single-center retrospective cohort study included all patients referred for T-TEER with severe and symptomatic TR with high surgical risk from April 2021 to March 2024.

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Background: Using three-dimensional (3D) modalities for optimal pre-procedure planning in transcatheter aortic valve replacement (TAVR) is critical for procedural success. However, current methods rely on visualizing images on a two-dimensional screen, using shading and colors to create the illusion of 3D, potentially impeding the accurate comprehension of the actual anatomy structures. In contrast, a new Mixed Reality (MxR) based software enables accurate 3D visualization, imaging manipulation, and quantification of measurements.

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Head and neck paragangliomas (HNPGLs) are rare and have high rates of genetic mutations. We conducted a retrospective review of 187 patients with 296 PGLs diagnosed between 1974 and 2023. The mean age of diagnosis was 48.

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  • The COVID-19 pandemic has severely affected individuals with hematological malignancies due to their weakened immune systems, resulting in higher mortality rates and severe outcomes.
  • Data from the EPICOVIDEHA registry, which compiles COVID-19 cases from these patients worldwide, was collected from 2020 to 2022, including 8,767 cases from 152 centers across 41 countries.
  • Findings show a significant drop in critical infections and overall mortality rates, but hospitalization (especially in ICU) remains a serious risk factor; vaccination is linked to better survival outcomes, highlighting the need for ongoing monitoring and support for these patients.
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  • - Interest in transcatheter treatment for tricuspid regurgitation (TR) has increased due to its link to mortality and the scarcity of surgical options for high-risk patients.
  • - The transcatheter approach includes edge-to-edge repair and direct annuloplasty, the latter using an adjustable band to reduce TR and enhance heart failure symptoms.
  • - Successful procedures rely on careful patient selection and advanced imaging techniques, with challenges in imaging due to device shadowing, requiring precise alignment and monitoring during the procedure.
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Naturalized dyes (NDs) are innovative and eco-friendly synthetic compounds in which a chromophore is covalently linked to a natural sugar (e.g., lactose).

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  • Loss of function variants in the NF1 gene lead to neurofibromatosis type 1 (NF1), a hereditary condition with a 1 in 3,000 prevalence, notable physical signs, and heightened cancer risk.
  • A genotype-first approach revealed a higher-than-expected prevalence of pathogenic variants (1 in 450-750), many found in individuals without typical NF1 symptoms.
  • These variants often showed post-zygotic mosaicism and were linked to increased cancer risks, indicating they may be more common and less penetrant than previously recognized.
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Evaluation of the right ventricle (RV) in patients with acute myocarditis (MY) remains challenging with both 2D transthoracic echocardiography (TTE) and cardiovascular magnetic resonance (CMR). We examined the incremental diagnostic value of CMR feature tracking (FT) to evaluate RV involvement in patients with myocarditis. We enrolled 54 patients with myocarditis and preserved left ventricle (LV) ejection fraction (EF).

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Objectives: The identification of patients with mitral valve prolapse (MVP) presenting high arrhythmic risk remains challenging. Cardiovascular Magnetic Resonance (CMR) feature tracking (FT) may improve risk stratification. We analyzed the role of CMR-FT parameters in relation to the incidence of complex ventricular arrhythmias (cVA) in patients with MVP and mitral annular disjunction (MAD).

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Multiple valve heart disease refers to the simultaneous presence of several valvular anomalies, while mixed valvular heart disease refers to the combination of stenotic lesions or regurgitation affecting the same valve. The pathophysiology of multiple and mixed valvular heart disease depends on the combination of affected valves and the severity of the individual valvular defects. Imaging is essential for diagnosis and assessment of disease severity.

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Introduction And Objectives: The incidence of device infection has increased over time and is associated with increased mortality in patients with cardiac implantable electronic devices (CIEDs). Gentamicin-impregnated collagen sponges (GICSs) are useful in preventing surgical site infection (SSI) in cardiac surgery. Nevertheless, to date, there is no evidence concerning their use in CIED procedures.

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Plerixafor is widely used as up-front treatment with G-CSF to enhance peripheral blood hematopoietic stem cell output in patients failing previous mobilizations. Less frequently, plerixafor is used to rescue an unsatisfactory mobilization following chemotherapy (CT) and G-CSF. This study investigates if pre-collection factors affect the CD34+ cell harvest in chemotherapy and G-CSF mobilizations rescued by plerixafor.

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An acute, transient episode of left ventricular dysfunction characterizes Takotsubo syndrome. It represents about 2% of all cases of acute coronary syndrome (ACS), and occurs predominantly in postmenopausal women, generally following a significant physical or emotional stressor. It can be diagnosed based on clinical symptoms and the absence of coronary artery disease on angiography.

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Background: Conventional angioplasty balloon catheter, drug coated balloon (DCB), or angioplasty with drug eluting stent (DES) have been used on the percutaneous treatment of erectile dysfunction (ED). Currently available DCBs are paclitaxel eluting balloon (PEB), very recently, sirolimus eluting balloon (SEB). Although endovascular revascularization with balloon resulted in improvement of ED, there have been no prior reports on the feasibility of SEB treatment for ED.

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  • * The Omicron variant was the most common strain detected (68.7%), with a notable 9% mortality rate within 30 days of diagnosis, which is lower compared to the pre-vaccine era's 31%.
  • * Factors like older age, active HM, and severe COVID-19 increased mortality, while treatment with monoclonal antibodies reduced the death rate, demonstrating that even vaccinated patients with HM remain at significant risk for severe outcomes.
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The aim of our study was to determine the feasibility and efficacy of transaxillary (TAX) TAVI in patients not eligible for the transfemoral route. This is a retrospective study of a single center. We analysed 262 patients treated with TAVI.

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The foundation of an energy sustainable Web of Industrial Things (WoIT) is facing several open issues due to the constraints imposed by the involved devices, the technological heterogeneity and the complex interactions and, hence, communications patterns. Towards this goal, in this paper, a general framework inspired by the Publish-Subscribe principle have been proposed, in order to jointly optimize the service requirements and the network availability. In particular, in this paper we focus on a holistic design with the objective to manage power budget distribution, in order to support applications that extend the basic publish-and-subscribe scheme.

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