Serratia montpellierensis sp. nov., Isolated from Laboratory-Reared Parasitic Wasps Psyttalia lounsburyii Silvestri and Psyttalia ponerophaga Silvestri (Hymenoptera: Braconidae).

Two strains of bacteria, PsyLou2A and PsyPon4B, were isolated from adult braconid wasps Psyttalia lounsburyii and Psyttalia ponerophaga, respectively. These laboratory-reared wasps were investigated as agents for biological control of the olive fruit fly, Bactrocera oleae. Analysis of 16S rRNA genes of the two isolates demonstrated that they were highly related and belonged to the genus Serratia.

Individual In-Situ GPS-Derived Acceleration-Speed Profiling: Toward Automatization and Refinement in Male Professional Rugby Union Players.

Background: Recently a proof-of-concept was proposed to derive the soccer players' individual in-situ acceleration-speed (AS) profile from global positioning system (GPS) data collected over several sessions and games. The present study aimed to propose an automatized method of individual GPS-derived in-situ AS profiling in a professional rugby union setting.

Method: AS profiles of forty-nine male professional rugby union players representing 61.

Cultivation of monoxenous trypanosomatids: A minireview.

Trypanosomatids are obligatory parasites, some of which are responsible for important human and animal diseases, but the vast majority of trypanosomatids are restricted to invertebrate hosts. Isolation and in vitro cultivation of trypanosomatids from insect hosts enable their description, characterization, and subsequently genetic and genomic studies. However, exact nutritional requirements are still unknown for most trypanosomatids and thus very few defined media are available.

Characterization of Sulfur-Rich Microbial Organic Matter in Jurassic Carbonates Using Laser-Assisted Mass Spectrometry.

Laser desorption-ionization mass spectrometry (MS) shows great potential for molecular analysis of planetary surfaces and microanalysis of space-returned samples or (micro)fossils. Coupled with pyrolysis gas chromatography-mass spectrometry (Py-GC-MS) in ESA's ExoMars project, this technique could help assess further the origin of sulfur-bearing organic matter (OM) recently detected on Mars. To unravel this potential, we analyzed sulfurized microbial OM from ca.

Relief of nocturnal neuropathic pain with the use of cannabis in a patient with Fabry disease.

Neuropathic pain is one of the most invalidating symptoms in patients with Fabry disease (FD), affecting their quality of life, it is linked to small fiber neuropathy and it may not respond to available disease specific treatments. We report the case of a 32 years old man with classic FD and severe neuropathic pain who, after the failure of several standard pharmaceutical approaches, was treated with medical cannabis with relief of nocturnal pain and sleep improvement.

A Novel Prebiotic Fibre Blend Supports the Gastrointestinal Health of Senior Dogs.

Senior pets can suffer from a wide range of age-related diseases that can impact the quality of life for the pet and the relationship between a pet and their owner. Dietary fibre plays a key role in shaping the gastrointestinal health in mammalian species. The aim of this study was to investigate the impact of a novel prebiotic fibre blend containing sugar beet pulp, galacto-oligosaccharides, and cellulose on the health of senior dogs when fed on top of a background commercial dry diet.

Biological and physico-chemical characterization of human norovirus-like particles under various environmental conditions.

Human noroviruses (HuNoVs) are the predominant etiological agent of viral gastroenteritis in all age groups worldwide. Mutations over the years have affected noroviruses' responses to environmental conditions due to the arrangement of amino acid residues exposed on the VP1 capsid surface of each strain. The GII.

Reactivity of Covalent Fragments and Their Role in Fragment Based Drug Discovery.

Fragment based drug discovery has long been used for the identification of new ligands and interest in targeted covalent inhibitors has continued to grow in recent years, with high profile drugs such as osimertinib and sotorasib gaining FDA approval. It is therefore unsurprising that covalent fragment-based approaches have become popular and have recently led to the identification of novel targets and binding sites, as well as ligands for targets previously thought to be 'undruggable'. Understanding the properties of such covalent fragments is important, and characterizing and/or predicting reactivity can be highly useful.

Gut transcriptome reveals differential gene expression and enriched pathways linked to immune activation in response to weaning in pigs.

Weaning represents one of the most critical periods in pig production associated with increase in disease risk, reduction in performance and economic loss. Physiological changes faced by piglets during the weaning period have been well characterised, however little is currently known about the underlying molecular pathways involved in these processes. As pig meat remains one of the most consumed sources of protein worldwide, understanding how these changes are mediated is critical to improve pig production and consequently sustainable food production globally.

Transnational Migration and Dual Career of Slovenian and Swiss Elite Female Handball Players-A Longitudinal Analysis.

The purpose of this study was to identify the career paths of transnational migrating female elite handball players. Fourteen Slovenian and Suisse national team players were monitored over a 7-year period by means of semi-structured interviews and official handball records. At the end of the examination period, six still-active players were interviewed again.

Correlation between Employee Performance, Well-Being, Job Satisfaction, and Life Satisfaction in Sedentary Jobs in Slovenian Enterprises.

The purpose of this study was to explore the relationship between employees' work performance and their well-being, job satisfaction, and life satisfaction in sedentary jobs in Slovenian enterprises using a mixed-methods research design. The quantitative component of the research included the responses to four selected questionnaires of 120 employees in 22 identified enterprises (out of 81), with more than 20 employees, having more than 85 percent sedentary jobs. Each of four questionnaires was chosen to cover one area of enquiry under the research foci of work performance, job satisfaction, life satisfaction and well-being.

Fragment-based drug discovery-the importance of high-quality molecule libraries.

Fragment-based drug discovery (FBDD) is now established as a complementary approach to high-throughput screening (HTS). Contrary to HTS, where large libraries of drug-like molecules are screened, FBDD screens involve smaller and less complex molecules which, despite a low affinity to protein targets, display more 'atom-efficient' binding interactions than larger molecules. Fragment hits can, therefore, serve as a more efficient start point for subsequent optimisation, particularly for hard-to-drug targets.

Integrative Taxonomy and Synonymization of (Acari: Eriophyidae), a Potential Biological Control Agent for Tree of Heaven ().

The taxonomy of appears to be an unresolved question and its clarification is required, owing to the potential relevance of this mite species as a biological control agent of the tree of heaven. This paper is aimed at giving accurate details on a previously and shortly announced synonymization with using a morphological and molecular approach. A fusiform morph of was distinguished from a vermiform morph and this latter was recognized as deutogyne, which was herein documented.

Common colonic community indicators of the suckling pig microbiota where diversity and abundance correlate with performance.

The primary objective of this study was to investigate if common colonic community indicators could be identified from the microbiota of 22-day-old suckling pigs in repeated small-scale trials. A total of three separate trials were conducted at different times in the same year and facility with genetically similar animals. Colonic samples were collected from four pigs in each trial and the microbiome composition assessed by 16s rRNA gene sequencing.

Gross Morphology of Diseased Tissues in Nezara viridula (Hemiptera: Pentatomidae) and Molecular Characterization of an Associated Microsporidian.

Nezara viridula (L.) (Hemiptera: Pentatomidae), commonly known in the U.S.

Morpho-Functional Traits Reveal Differences in Size Fractionated Phytoplankton Communities but Do Not Significantly Affect Zooplankton Grazing.

The recent emergence of approaches based on functional traits allows a more comprehensive evaluation of the role of functions and interactions within communities. As phytoplankton size and shape are the major determinants of its edibility to herbivores, alteration or loss of some morpho-functional phytoplankton traits should affect zooplankton grazing, fitness and population dynamics. Here, we investigated the response of altered phytoplankton morpho-functional trait distribution to grazing by zooplankton with contrasting food size preferences and feeding behaviors.

MEK inhibition overcomes chemoimmunotherapy resistance by inducing CXCL10 in cancer cells.

Chemotherapy with anti PD-1/PD-L1 antibodies has become the standard of care for patients with metastatic non-small cell lung cancer (mNSCLC). Using lung tumor models, where pemetrexed and cisplatin (PEM/CDDP) chemotherapy remains unable to synergize with immune checkpoint inhibitors (ICIs), we linked the failure of this treatment with its inability to induce CXCL10 expression and CD8 T cell recruitment. Using drug screening, we showed that combining a MEK inhibitor (MEKi) with PEM/CDDP triggers CXCL10 secretion by cancer cells and CD8 T cell recruitment, sensitizing it to ICIs.

Taxonomic Description of n. sp. (Diptera: Cecidomyiidae), a Seed Parasite of Cheatgrass, , Based on Morphological and Mitochondrial DNA Data.

Cheatgrass is an annual grass species from Eurasia that has become invasive in much of western North America. It has been implicated in recent increases in the frequency, size, and intensity of wildfires, contributing to severe economic, environmental, and social destruction. In order to reduce this damage, the USDA-ARS established a classical biological control program against cheatgrass.

Field Assessment of the Host Range of (Acari: Eriophyidae), a Biological Control Agent of the Tree of Heaven ().

Tree of heaven () is a fast-growing deciduous tree native to China, considered a serious invasive species worldwide, with several socio-economic and ecological impacts attributed to it. Chemical and mechanical methods have limited efficacy in its management, and biological controls may offer a suitable and sustainable option. (Ripka) is an eriophyid mite that has been recorded to attack tree of heaven in 13 European countries.

Multi-national perceptions on challenges, opportunities, and support structures for Dual Career migrations in European student-athletes.

Despite Dual Careers (sports and education) and mobility of students being priorities in the funding policies of the European Commission, migrating student-athletes report severe challenges and decreased performance or dropouts at sport and academic levels. The objective of this study was to depict and assess the perceptions on challenges, support services, and their effectiveness in consideration of specific characteristics of participants and migrations. Based on a meta-synthesis and previous findings, a 50-items questionnaire was developed and completed by 245 student-athletes in 5 European countries.

Molecular Identification of , Parasitoid of the Brown Marmorated Stink Bug, by Species-Specific PCR.

The samurai wasp, (Ashmead), has been proposed as a biocontrol agent against brown marmorated stink bugs (BMSB), due to its ability to parasitize and kill BMSB eggs. However, the wasps' small size makes it challenging for those untrained in morphological identification to determine the wasps' species. To circumvent this problem, a molecular method was created to identify .

Size, microhabitat, and loss of larval feeding drive cranial diversification in frogs.

Habitat is one of the most important factors shaping organismal morphology, but it may vary across life history stages. Ontogenetic shifts in ecology may introduce antagonistic selection that constrains adult phenotype, particularly with ecologically distinct developmental phases such as the free-living, feeding larval stage of many frogs (Lissamphibia: Anura). We test the relative influences of developmental and ecological factors on the diversification of adult skull morphology with a detailed analysis of 15 individual cranial regions across 173 anuran species, representing every extant family.

Functional changes in benthic macrofaunal communities along a natural gradient of hypoxia in an upwelling system.

Increasing global concern has been raised about the expansion of hypoxia in coastal waters and its potential to impact benthic ecosystems. Upwelling areas offer opportunities to study the effects of hypoxia on benthic communities under natural conditions. We used a biological trait-based approach and estimated functional diversity indices to assess macrobenthic community functioning along a depth gradient associated with naturally increasing hypoxia and concentrations of organic matter in the upwelling zone of northern Chile (South-East Pacific) over two years.