Exosome-like nanoparticles from Mulberry bark prevent DSS-induced colitis via the AhR/COPS8 pathway.

Bark protects the tree against environmental insults. Here, we analyzed whether this defensive strategy could be utilized to broadly enhance protection against colitis. As a proof of concept, we show that exosome-like nanoparticles (MBELNs) derived from edible mulberry bark confer protection against colitis in a mouse model by promoting heat shock protein family A (Hsp70) member 8 (HSPA8)-mediated activation of the AhR signaling pathway.

Melatonin promotes plant growth by increasing nitrogen uptake and assimilation under nitrogen deficient condition in winter wheat.

Melatonin (MEL) has been widely reported to be beneficial to plant growth and development, but few studies have combined investigations of the performance and function of MEL with detailed physiologically based analyses of nitrogen (N) uptake and metabolism in staple crops. In this study, the effect of MEL application on winter wheat seedling growth and grain yield were investigated in hydroponic and pot experiments at different N levels. The result showed that application of 1 μM MEL in hydroponic solution significantly improved the wheat seedling growth under both N sufficient and deficient conditions, but the effect of MEL on promoting seedling growth was prominent under N deficient condition.

Melatonin Mitigates Salt Stress in Wheat Seedlings by Modulating Polyamine Metabolism.

Melatonin, a small molecular weight indoleamine molecule, is involved in various biological processes and responses to environmental cues in plants. However, its function in abiotic stress response and the underlying mechanisms is less clear. In this study, we investigated the effect of melatonin on wheat seedlings growth under salt stress condition.